FR2258863A1 - Antiviral lipopolysaccharides - obtd. from Pseudomonas aeruginosa FH-N-845 (ATCC-21 966) - Google Patents
Antiviral lipopolysaccharides - obtd. from Pseudomonas aeruginosa FH-N-845 (ATCC-21 966)Info
- Publication number
- FR2258863A1 FR2258863A1 FR7502381A FR7502381A FR2258863A1 FR 2258863 A1 FR2258863 A1 FR 2258863A1 FR 7502381 A FR7502381 A FR 7502381A FR 7502381 A FR7502381 A FR 7502381A FR 2258863 A1 FR2258863 A1 FR 2258863A1
- Authority
- FR
- France
- Prior art keywords
- acid
- lipopolysaccharides
- antiviral
- obtd
- atcc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002158 endotoxin Substances 0.000 title abstract 2
- 229920006008 lipopolysaccharide Polymers 0.000 title abstract 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 title 1
- 230000000840 anti-viral effect Effects 0.000 title 1
- MUCMKTPAZLSKTL-UHFFFAOYSA-N (3RS)-3-hydroxydodecanoic acid Natural products CCCCCCCCCC(O)CC(O)=O MUCMKTPAZLSKTL-UHFFFAOYSA-N 0.000 abstract 3
- FYSSBMZUBSBFJL-UHFFFAOYSA-N 3-hydroxydecanoic acid Chemical compound CCCCCCCC(O)CC(O)=O FYSSBMZUBSBFJL-UHFFFAOYSA-N 0.000 abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- BWZVCCNYKMEVEX-UHFFFAOYSA-N 2,4,6-Trimethylpyridine Chemical compound CC1=CC(C)=NC(C)=C1 BWZVCCNYKMEVEX-UHFFFAOYSA-N 0.000 abstract 1
- 208000009889 Herpes Simplex Diseases 0.000 abstract 1
- 102000014150 Interferons Human genes 0.000 abstract 1
- 108010050904 Interferons Proteins 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- YDZIJQXINJLRLL-UHFFFAOYSA-N alpha-hydroxydodecanoic acid Natural products CCCCCCCCCCC(O)C(O)=O YDZIJQXINJLRLL-UHFFFAOYSA-N 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 229940079322 interferon Drugs 0.000 abstract 1
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 abstract 1
- 239000007922 nasal spray Substances 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 208000003265 stomatitis Diseases 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 208000005925 vesicular stomatitis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/38—Pseudomonas
- C12R2001/385—Pseudomonas aeruginosa
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
New lipopolysaccharides comprise chains of O-specific sugars, nuclear polysaccharide and lipid A with a relative fatty acid content of: 8-13 (9-11)% dodecanoic acid, 31-39 (33-37)% 2-hydroxydodecanoic acid, 22-29 (23-27)% 3-hydroxydecanoic acid, 23-27 (24-26)% 3-hydroxydodecanoic acid and 0-7(4-6)% other fatty acids. Antiviral agent useful in small doses, e.g. 1/100 of that of interferon, for prophylaxis against e.g. Influenza A0, A2 or B/Lee, Encephalomyocarditis, Vesicular stomatitis, Herpes Simplex 1 viruses etc., and also for therapy (less active). Doses are e.g. 10-100 mcg/kg in nasal sprays or for injection etc.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2403733A DE2403733A1 (en) | 1974-01-26 | 1974-01-26 | NEW LIPOPOLYSACCHARIDES AND METHODS FOR THEIR PRODUCTION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2258863A1 true FR2258863A1 (en) | 1975-08-22 |
Family
ID=5905749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7502381A Withdrawn FR2258863A1 (en) | 1974-01-26 | 1975-01-27 | Antiviral lipopolysaccharides - obtd. from Pseudomonas aeruginosa FH-N-845 (ATCC-21 966) |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS50101585A (en) |
| BE (1) | BE824815A (en) |
| DE (1) | DE2403733A1 (en) |
| DK (1) | DK23275A (en) |
| FR (1) | FR2258863A1 (en) |
| LU (1) | LU71718A1 (en) |
| NL (1) | NL7500685A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2444464A1 (en) * | 1978-12-19 | 1980-07-18 | Fabre Sa Pierre | PURIFIED BACTERIAL PROTEOGLYCANS, PROCESS FOR THEIR PREPARATION AND VACCINE CONTAINING THEM |
| EP0161511A2 (en) * | 1984-04-16 | 1985-11-21 | The Board Of Trustees Of The University Of Illinois | Pseudomonas bacteria, emulsifying composition comprising pseudomonas bacteria and method of producing a composition comprising pseudomonas bacteria |
| EP0462020A2 (en) * | 1990-06-15 | 1991-12-18 | Chiba Flour Milling Co. Ltd. | Anti-herpes agents and veterinary anti-herpes agent |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3463167A (en) * | 1967-07-24 | 1969-08-26 | Ervin A Kubert | Smoking pipe |
| JPS59161320A (en) * | 1983-03-04 | 1984-09-12 | Maruyama Chisato | Lipopolysaccharide and its preparation |
| JP2522945B2 (en) * | 1987-06-18 | 1996-08-07 | 呉羽化学工業株式会社 | Antiretroviral agent |
-
1974
- 1974-01-26 DE DE2403733A patent/DE2403733A1/en active Pending
-
1975
- 1975-01-21 NL NL7500685A patent/NL7500685A/en unknown
- 1975-01-24 LU LU71718A patent/LU71718A1/xx unknown
- 1975-01-24 DK DK23275*BA patent/DK23275A/da unknown
- 1975-01-25 JP JP50010177A patent/JPS50101585A/ja active Pending
- 1975-01-27 FR FR7502381A patent/FR2258863A1/en not_active Withdrawn
- 1975-01-27 BE BE152735A patent/BE824815A/en unknown
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2444464A1 (en) * | 1978-12-19 | 1980-07-18 | Fabre Sa Pierre | PURIFIED BACTERIAL PROTEOGLYCANS, PROCESS FOR THEIR PREPARATION AND VACCINE CONTAINING THEM |
| EP0013851A1 (en) * | 1978-12-19 | 1980-08-06 | Pierre Fabre S.A. | Purified bacterial proteoglycans, process for their preparation and vaccine containing them |
| EP0161511A2 (en) * | 1984-04-16 | 1985-11-21 | The Board Of Trustees Of The University Of Illinois | Pseudomonas bacteria, emulsifying composition comprising pseudomonas bacteria and method of producing a composition comprising pseudomonas bacteria |
| EP0161511A3 (en) * | 1984-04-16 | 1987-06-16 | Univ Illinois | Pseudomonas bacteria, emulsifying composition comprising pseudomonas bacteria and method of producing a composition comprising pseudomonas bacteria |
| EP0462020A2 (en) * | 1990-06-15 | 1991-12-18 | Chiba Flour Milling Co. Ltd. | Anti-herpes agents and veterinary anti-herpes agent |
| EP0462020A3 (en) * | 1990-06-15 | 1992-04-29 | Chiba Flour Milling Co. Ltd. | Anti-herpes agents and veterinary anti-herpes agent |
Also Published As
| Publication number | Publication date |
|---|---|
| BE824815A (en) | 1975-07-28 |
| DK23275A (en) | 1975-09-15 |
| JPS50101585A (en) | 1975-08-12 |
| NL7500685A (en) | 1975-07-29 |
| LU71718A1 (en) | 1976-12-31 |
| DE2403733A1 (en) | 1975-08-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MY103388A (en) | Azithromycin and derivatives as antiprotozoal agents | |
| MY107843A (en) | Anti-viral compounds. | |
| ES8700053A1 (en) | Antiviral pharmaceutical preparations and their use. | |
| CS395791A3 (en) | Derivatives of polysulfuric esters of bis-hexonoic acid amides | |
| FR2258863A1 (en) | Antiviral lipopolysaccharides - obtd. from Pseudomonas aeruginosa FH-N-845 (ATCC-21 966) | |
| AR245734A1 (en) | A procedure for preparing a polydextrose soluble in water. | |
| DE69331465D1 (en) | INTRAVENOUS SOLUTION THAT REDUCES PROTEIN AND WATER LOSS IN THE BODY | |
| GB1164569A (en) | Improvements in or relating to Antilipaemic Sulphated Polysaccharides | |
| ES2062529T3 (en) | USE OF ALIPHATIC ALCOHOLS, FROM C-20 TO C-26, FOR THE REALIZATION OF A MEDICINE INTENDED FOR THE TREATMENT OF VIRAL INFECTIONS. | |
| GB1270049A (en) | New pharmaceutical product | |
| USD208238S (en) | Spray header for food processing conveyor systems or the like | |
| FR2142194A5 (en) | Allergen-free pollen extracts - stabilized by freeze-drying | |
| JPS5543041A (en) | Immunity raising agent | |
| JPS54148090A (en) | Peroral cholesterol-depressant | |
| ES2010559A6 (en) | Topical process for treating herpes infections using 5-isopropyl-2'- beta -deoxyuridine as the active agent | |
| GB1229229A (en) | ||
| FR2410476A1 (en) | Peptidoglycan extracts of bacteria, esp. Bacillus species - for stimulating antitumour immunity | |
| GB1166794A (en) | Solutions of Poly(Acyl Oxamidrazones) | |
| GB8719670D0 (en) | Pharmaceutical compositions | |
| USD216872S (en) | Hook for meat or similar articles | |
| GB1229527A (en) | ||
| USD220424S (en) | Grounding clip | |
| GB1030246A (en) | Improvements in or relating to acid addition salts of biologically active polypeptides | |
| USD219738S (en) | Gun mount | |
| JPS5798212A (en) | Carcinostatic agent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |