FR2258178A1 - Alpha-heteroaryl-alkanethiocarboxamides - useful as gastric secretion inhibitors - Google Patents

Alpha-heteroaryl-alkanethiocarboxamides - useful as gastric secretion inhibitors

Info

Publication number
FR2258178A1
FR2258178A1 FR7501116A FR7501116A FR2258178A1 FR 2258178 A1 FR2258178 A1 FR 2258178A1 FR 7501116 A FR7501116 A FR 7501116A FR 7501116 A FR7501116 A FR 7501116A FR 2258178 A1 FR2258178 A1 FR 2258178A1
Authority
FR
France
Prior art keywords
heteroaryl
opt
alkanethiocarboxamides
alpha
substd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7501116A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of FR2258178A1 publication Critical patent/FR2258178A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/59—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with at least one of the bonds being to sulfur

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Alpha-Heteroaryl-alkanethiocarboxamides of formula (I) and their acid-addn. salts are new: (where Het is an opt. substd. heteroaryl gp. contg. at least one ring N atom, the free valence of which is on a C atom adjacent to an N atom; X is an alkylene or a direct bond; R1 is an opt. substd. hydrocarbon residue opt. interrupted by one or more heteroatoms; R2 is an opt. substd. amino gp.). Cpds. (I) inhibit gastric acid secretion and can be used to treat peptic disorders, e.g., hyperacidity.
FR7501116A 1974-01-17 1975-01-15 Alpha-heteroaryl-alkanethiocarboxamides - useful as gastric secretion inhibitors Withdrawn FR2258178A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH61974 1974-01-17

Publications (1)

Publication Number Publication Date
FR2258178A1 true FR2258178A1 (en) 1975-08-18

Family

ID=4191218

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7501116A Withdrawn FR2258178A1 (en) 1974-01-17 1975-01-15 Alpha-heteroaryl-alkanethiocarboxamides - useful as gastric secretion inhibitors

Country Status (9)

Country Link
JP (1) JPS50101364A (en)
AU (1) AU7733975A (en)
BE (1) BE824426A (en)
DE (1) DE2501286A1 (en)
DK (1) DK627174A (en)
FR (1) FR2258178A1 (en)
IL (1) IL46448A0 (en)
NL (1) NL7500022A (en)
SE (1) SE7415602L (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2405935A1 (en) * 1977-08-23 1979-05-11 Sagami Chem Res (PYRROLYL-2) THIO-ACETAMIDES THAT CAN BE USED FOR THE SYNTHESIS OF ACTIVE SUBSTANCES IN MEDICINAL PRODUCTS AND PHYTOSANITARY PRODUCTS
FR2416887A1 (en) * 1978-02-09 1979-09-07 Morishita Pharma Antiulcer thioamide derivs. - prepd. by treating nitrile or acid amide deriv. with an inorganic sulphide and/or sulphonyl halide
US4272534A (en) * 1979-03-30 1981-06-09 Rhone-Poulenc Industries 2-(Pyrid-2-yl)tetrahydrothiophene derivatives
FR2488609A1 (en) * 1980-08-18 1982-02-19 Rhone Poulenc Ind NOVEL DERIVATIVES OF THIOFORMAMIDE, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM
EP0073704B1 (en) * 1981-08-11 1986-11-12 Rhone-Poulenc Sante Heterocyclic nitriles, their preparation and their use in the preparation of medicaments

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2405935A1 (en) * 1977-08-23 1979-05-11 Sagami Chem Res (PYRROLYL-2) THIO-ACETAMIDES THAT CAN BE USED FOR THE SYNTHESIS OF ACTIVE SUBSTANCES IN MEDICINAL PRODUCTS AND PHYTOSANITARY PRODUCTS
FR2416887A1 (en) * 1978-02-09 1979-09-07 Morishita Pharma Antiulcer thioamide derivs. - prepd. by treating nitrile or acid amide deriv. with an inorganic sulphide and/or sulphonyl halide
US4272534A (en) * 1979-03-30 1981-06-09 Rhone-Poulenc Industries 2-(Pyrid-2-yl)tetrahydrothiophene derivatives
FR2488609A1 (en) * 1980-08-18 1982-02-19 Rhone Poulenc Ind NOVEL DERIVATIVES OF THIOFORMAMIDE, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM
EP0046417A1 (en) * 1980-08-18 1982-02-24 Rhone-Poulenc Sante Thioformamide derivatives, their preparation and pharmaceutical preparations containing them
EP0077083A1 (en) * 1980-08-18 1983-04-20 Rhone-Poulenc Sante Thioformamide derivatives, their preparation and medicines containing them
EP0073704B1 (en) * 1981-08-11 1986-11-12 Rhone-Poulenc Sante Heterocyclic nitriles, their preparation and their use in the preparation of medicaments

Also Published As

Publication number Publication date
NL7500022A (en) 1975-07-21
IL46448A0 (en) 1975-04-25
DK627174A (en) 1975-09-08
AU7733975A (en) 1976-07-15
DE2501286A1 (en) 1975-07-24
SE7415602L (en) 1975-07-18
BE824426A (en) 1975-07-16
JPS50101364A (en) 1975-08-11

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Legal Events

Date Code Title Description
ST Notification of lapse