FR2230374A1 - Phosphonates contg. a P-32 or P-33 radionuclide - prepd. by reaction of labelled phosphorus trichloride and acid - Google Patents

Phosphonates contg. a P-32 or P-33 radionuclide - prepd. by reaction of labelled phosphorus trichloride and acid

Info

Publication number
FR2230374A1
FR2230374A1 FR7417965A FR7417965A FR2230374A1 FR 2230374 A1 FR2230374 A1 FR 2230374A1 FR 7417965 A FR7417965 A FR 7417965A FR 7417965 A FR7417965 A FR 7417965A FR 2230374 A1 FR2230374 A1 FR 2230374A1
Authority
FR
France
Prior art keywords
cpds
tumours
labelled
contg
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7417965A
Other languages
French (fr)
Other versions
FR2230374B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of FR2230374A1 publication Critical patent/FR2230374A1/en
Application granted granted Critical
Publication of FR2230374B1 publication Critical patent/FR2230374B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Abstract

(A) Cpds. of the fllowing formulae labelled with the radio-isotopes 32P or 33P are stated to be new: and the labelled cpds. 1,2-dicarboxyethylene-1-phosphonic acid and ethylene-1,1-diphosphonic acid. (R=H or CH2OH; n=3-10; R1=H, 1-20C alkyl, 2-20C alkenyl, aryl, phenylethyl, benzyl, halo, OH, opt. substd. amino, carboxymethyl, CH2PO3H2, CHOH.PO3H2 or - [CH2C(PO3H2)2]n'H; n' = 1-15; R2 = H, alkyl, NH2, benzyl, halo, OH, CH2COOH, CH2PO3H2 or CH2CH2PO3H2; m=3-9; R3=H or alkyl; p=2-4; X and Y = H or OH). Salts of these cpds. are included. (B) Claims are restricted to compsns. for treatment of tumours contg. these cpds. The cpds. may be used in the treatment of calcareous tumours, such as primary- and metastic bone tumours and tumours which calcify soft tissue. They may also be used in combined therapy with other chemotherapeutic agents. The cpds. have a high selectivity for calcareous tumours of up to 40:1 with respect to normal bone. They have very low soft-tissue retention and few side-effects.
FR7417965A 1973-05-23 1974-05-22 Phosphonates contg. a P-32 or P-33 radionuclide - prepd. by reaction of labelled phosphorus trichloride and acid Granted FR2230374A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36297173A 1973-05-23 1973-05-23

Publications (2)

Publication Number Publication Date
FR2230374A1 true FR2230374A1 (en) 1974-12-20
FR2230374B1 FR2230374B1 (en) 1978-07-21

Family

ID=23428261

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7417965A Granted FR2230374A1 (en) 1973-05-23 1974-05-22 Phosphonates contg. a P-32 or P-33 radionuclide - prepd. by reaction of labelled phosphorus trichloride and acid

Country Status (6)

Country Link
BE (1) BE815397A (en)
DE (1) DE2424453C3 (en)
FR (1) FR2230374A1 (en)
NL (1) NL7406952A (en)
PH (1) PH12898A (en)
ZA (1) ZA743159B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000076556A2 (en) * 1999-06-11 2000-12-21 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
EP1426063A3 (en) * 2000-02-18 2004-07-14 Civatech Corporation Brachytherapy seeds and stents that can be activated by neutron rays
US7118729B1 (en) 1999-07-12 2006-10-10 Civatech Corporation Radioactive source materials formable into various shapes
US7686756B2 (en) 2006-08-29 2010-03-30 Ciratech Oncology Brachytherapy devices and related methods and computer program products

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000076556A2 (en) * 1999-06-11 2000-12-21 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
WO2000076556A3 (en) * 1999-07-11 2001-10-11 Neorx Corp High dose radionuclide complexes for bone marrow suppression
US7118729B1 (en) 1999-07-12 2006-10-10 Civatech Corporation Radioactive source materials formable into various shapes
US8012455B2 (en) 1999-07-12 2011-09-06 Civatech Corporation Radioactive source materials formable into various shapes
EP1426063A3 (en) * 2000-02-18 2004-07-14 Civatech Corporation Brachytherapy seeds and stents that can be activated by neutron rays
US7686756B2 (en) 2006-08-29 2010-03-30 Ciratech Oncology Brachytherapy devices and related methods and computer program products
US9358377B2 (en) 2006-08-29 2016-06-07 Civatech Onocology Brachytherapy devices and related methods and computer program products

Also Published As

Publication number Publication date
FR2230374B1 (en) 1978-07-21
BE815397A (en) 1974-11-22
NL7406952A (en) 1974-11-26
DE2424453B2 (en) 1980-06-12
ZA743159B (en) 1975-05-28
PH12898A (en) 1979-10-04
DE2424453C3 (en) 1981-02-26
DE2424453A1 (en) 1974-12-12

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Legal Events

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