BE800689A - Inhibiting calcium phosphate mobilise - with agents contg org phosphonic acids and vitamins - Google Patents
Inhibiting calcium phosphate mobilise - with agents contg org phosphonic acids and vitaminsInfo
- Publication number
- BE800689A BE800689A BE132074A BE132074A BE800689A BE 800689 A BE800689 A BE 800689A BE 132074 A BE132074 A BE 132074A BE 132074 A BE132074 A BE 132074A BE 800689 A BE800689 A BE 800689A
- Authority
- BE
- Belgium
- Prior art keywords
- po3h2
- mobilise
- vitamins
- org
- calcium phosphate
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 229910000389 calcium phosphate Inorganic materials 0.000 title 1
- 239000001506 calcium phosphate Substances 0.000 title 1
- 235000011010 calcium phosphates Nutrition 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 150000003009 phosphonic acids Chemical class 0.000 title 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
- OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 abstract 1
- 229960002535 alfacalcidol Drugs 0.000 abstract 1
- 230000002547 anomalous effect Effects 0.000 abstract 1
- 230000001749 antrachitic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 1
- 235000005282 vitamin D3 Nutrition 0.000 abstract 1
- 239000011647 vitamin D3 Substances 0.000 abstract 1
- 229940021056 vitamin d3 Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Pharmaceutical or veterinary prepds. for inhibiting anomalous Ca phosphate mobilisation comprise (a) an effective amt. of >=1 cpds. of formulae (I)-(X): R (CHPO3H2)nR (I): R1C(PO3H2)2R (II); (CH2)o (PO3H2)2 (III); N(C(R3)2PO3H2)3 (IV); (CF2)p HOOCCH=C-PO3H2 H2O3P-CH2-CO-PO3H2 H2C = C(PO3H2)2 (X) (where each R is H or CH2OH; n = 3-10; R1 is H, 1-20C alkyl, 2-20C alkenyl, aryl, phenethyl, benzyl, halogen, OH, NH2, substd. amino, CH2COOH, CH2PO3H2, CH(OH)PO3H2 or (CH2C(PO3H2)2)mH(m = 1-15); R2 is H1 lower alkyl, NH2 benzyl, halogen, OH, CH2COOH, CH2PO3H2 or CH2CH2PO3H2; o = 3-9; each R5 is H or lower alkyl; p = 2-4; X and Y are each H or OH) and/or their salts, and (b) 100-50,000 IU of >=1 antirachitic vitamin-D-type cpds., esp. vitamin D3 or 1 alpha-hydroxycholecalciferol.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26093972A | 1972-06-08 | 1972-06-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE800689A true BE800689A (en) | 1973-12-10 |
Family
ID=22991279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE132074A BE800689A (en) | 1972-06-08 | 1973-06-08 | Inhibiting calcium phosphate mobilise - with agents contg org phosphonic acids and vitamins |
Country Status (2)
| Country | Link |
|---|---|
| BE (1) | BE800689A (en) |
| ZA (1) | ZA733794B (en) |
-
1973
- 1973-06-05 ZA ZA733794A patent/ZA733794B/en unknown
- 1973-06-08 BE BE132074A patent/BE800689A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA733794B (en) | 1974-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: THE PROCTER & GAMBLE CY Effective date: 19900630 |