FR2005229A1 - Compositions preventing accumulation and deposition of - calcium phosphate in animal tissues - Google Patents
Compositions preventing accumulation and deposition of - calcium phosphate in animal tissuesInfo
- Publication number
- FR2005229A1 FR2005229A1 FR6900004A FR6900004A FR2005229A1 FR 2005229 A1 FR2005229 A1 FR 2005229A1 FR 6900004 A FR6900004 A FR 6900004A FR 6900004 A FR6900004 A FR 6900004A FR 2005229 A1 FR2005229 A1 FR 2005229A1
- Authority
- FR
- France
- Prior art keywords
- deposition
- calcium phosphate
- compositions
- animal tissues
- preventing accumulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 241001465754 Metazoa Species 0.000 title abstract 2
- 238000009825 accumulation Methods 0.000 title abstract 2
- 229910000389 calcium phosphate Inorganic materials 0.000 title abstract 2
- 239000001506 calcium phosphate Substances 0.000 title abstract 2
- 235000011010 calcium phosphates Nutrition 0.000 title abstract 2
- 230000008021 deposition Effects 0.000 title abstract 2
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229960004585 etidronic acid Drugs 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- -1 phenylethenyl Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical group [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compositions are provided for use in veterinary medicine to prevent accumulation and deposition of calcium phosphate in the tissues of animals afflicted with diseases such as osteoporosis, arthritis, renal and cystic calculi. The active ingredients of the compositions are polyphosphonic acids of formula (in which R1 and R2 = H or hydroxymethyl and n is an integer from 3 to 10; R3 = H, (1-20C) alkyl, (3-6C) cycloalkyl, (2-20C) alkenyl, aryl, phenylethenyl; benzyl, hal, opt. substd. NH2, CH2COOH, CH2PO3H2, CH(PO3H2)(OH), or CH2CH(PO3H2)2; R4=H, lower alkyl, NH2, benzyl, hal, OH, CH2COOH, CH2PO3H2, or CH2CH2PO3H2) or pharmaceutically acceptable salts thereof. The preferred active ingredient is the tri-Na salt of hydroxyethane diphosphonic acid.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68929067A | 1967-12-11 | 1967-12-11 | |
| US71799568A | 1968-04-01 | 1968-04-01 | |
| US77520368A | 1968-11-12 | 1968-11-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2005229A1 true FR2005229A1 (en) | 1969-12-12 |
Family
ID=27418517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR6900004A Withdrawn FR2005229A1 (en) | 1967-12-11 | 1969-01-02 | Compositions preventing accumulation and deposition of - calcium phosphate in animal tissues |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR2005229A1 (en) |
| IT (1) | IT1012003B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0275468A1 (en) * | 1986-12-20 | 1988-07-27 | Roche Diagnostics GmbH | Pharmaceutical compositions containing clodronate, and process for their preparation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1225818B (en) * | 1964-03-18 | 1966-09-29 | Monsanto Co | Use of water-soluble polyphosphonic acid compounds as potentizing agents for bactericides |
-
1968
- 1968-12-10 IT IT2486068A patent/IT1012003B/en active
-
1969
- 1969-01-02 FR FR6900004A patent/FR2005229A1/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1225818B (en) * | 1964-03-18 | 1966-09-29 | Monsanto Co | Use of water-soluble polyphosphonic acid compounds as potentizing agents for bactericides |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0275468A1 (en) * | 1986-12-20 | 1988-07-27 | Roche Diagnostics GmbH | Pharmaceutical compositions containing clodronate, and process for their preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| IT1012003B (en) | 1977-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |