FR2224137A2 - 3-(Alkyn-3-yloxy)-1-piperazinopropan-2-ols - with neuroleptic, antihypertensive, antiemetic and antitussive activity - Google Patents

3-(Alkyn-3-yloxy)-1-piperazinopropan-2-ols - with neuroleptic, antihypertensive, antiemetic and antitussive activity

Info

Publication number
FR2224137A2
FR2224137A2 FR7311884A FR7311884A FR2224137A2 FR 2224137 A2 FR2224137 A2 FR 2224137A2 FR 7311884 A FR7311884 A FR 7311884A FR 7311884 A FR7311884 A FR 7311884A FR 2224137 A2 FR2224137 A2 FR 2224137A2
Authority
FR
France
Prior art keywords
neuroleptic
piperazinopropan
alkyn
antiemetic
ols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7311884A
Other languages
French (fr)
Other versions
FR2224137B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre Europeen de Recherches Mauvernay CERM
Original Assignee
Centre Europeen de Recherches Mauvernay CERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Europeen de Recherches Mauvernay CERM filed Critical Centre Europeen de Recherches Mauvernay CERM
Priority to FR7311884A priority Critical patent/FR2224137A2/en
Publication of FR2224137A2 publication Critical patent/FR2224137A2/en
Application granted granted Critical
Publication of FR2224137B2 publication Critical patent/FR2224137B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The cpds. of formula (where R', R2 singly are alkyl or together are the group -(CH2)n - forming 5-8C cycloalkyl; A is a group where X is H, halogen CF3, alkyl, alkoxy, or a group where R is alkyl) are neuroleptic, hypotensive, antemetic and antitussive agents. All are prepd. as hydrochlorides.
FR7311884A 1973-04-03 1973-04-03 3-(Alkyn-3-yloxy)-1-piperazinopropan-2-ols - with neuroleptic, antihypertensive, antiemetic and antitussive activity Granted FR2224137A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7311884A FR2224137A2 (en) 1973-04-03 1973-04-03 3-(Alkyn-3-yloxy)-1-piperazinopropan-2-ols - with neuroleptic, antihypertensive, antiemetic and antitussive activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7311884A FR2224137A2 (en) 1973-04-03 1973-04-03 3-(Alkyn-3-yloxy)-1-piperazinopropan-2-ols - with neuroleptic, antihypertensive, antiemetic and antitussive activity

Publications (2)

Publication Number Publication Date
FR2224137A2 true FR2224137A2 (en) 1974-10-31
FR2224137B2 FR2224137B2 (en) 1977-04-22

Family

ID=9117299

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7311884A Granted FR2224137A2 (en) 1973-04-03 1973-04-03 3-(Alkyn-3-yloxy)-1-piperazinopropan-2-ols - with neuroleptic, antihypertensive, antiemetic and antitussive activity

Country Status (1)

Country Link
FR (1) FR2224137A2 (en)

Also Published As

Publication number Publication date
FR2224137B2 (en) 1977-04-22

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