FR2211249A1 - Cyclopropyl-substd. indomethacine analogues - anti-inflammatory, anti-pyretics, anti-arthritic and dermatologically active - Google Patents

Cyclopropyl-substd. indomethacine analogues - anti-inflammatory, anti-pyretics, anti-arthritic and dermatologically active

Info

Publication number
FR2211249A1
FR2211249A1 FR7345774A FR7345774A FR2211249A1 FR 2211249 A1 FR2211249 A1 FR 2211249A1 FR 7345774 A FR7345774 A FR 7345774A FR 7345774 A FR7345774 A FR 7345774A FR 2211249 A1 FR2211249 A1 FR 2211249A1
Authority
FR
France
Prior art keywords
alkyl
cyclopropyl
co2h
halo
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7345774A
Other languages
English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2211249A1 publication Critical patent/FR2211249A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/06—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7345774A 1972-12-21 1973-12-20 Cyclopropyl-substd. indomethacine analogues - anti-inflammatory, anti-pyretics, anti-arthritic and dermatologically active Withdrawn FR2211249A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31749672A 1972-12-21 1972-12-21

Publications (1)

Publication Number Publication Date
FR2211249A1 true FR2211249A1 (en) 1974-07-19

Family

ID=23233909

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7345774A Withdrawn FR2211249A1 (en) 1972-12-21 1973-12-20 Cyclopropyl-substd. indomethacine analogues - anti-inflammatory, anti-pyretics, anti-arthritic and dermatologically active

Country Status (4)

Country Link
JP (1) JPS4988868A (OSRAM)
DE (1) DE2363608A1 (OSRAM)
FR (1) FR2211249A1 (OSRAM)
NL (1) NL7316677A (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2438651A1 (fr) * 1978-10-12 1980-05-09 Glaxo Group Ltd Nouveaux derives d'indole utiles comme medicaments, procedes pour leur preparation et compositions pharmaceutiques les contenant
FR2488606A1 (fr) * 1980-08-12 1982-02-19 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
US4839377A (en) * 1980-08-12 1989-06-13 Glaxo Group Limited 5-substituted 3-aminoalkyl indoles

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6090666B2 (ja) * 2013-05-20 2017-03-08 国立大学法人富山大学 インドール誘導体および血糖降下剤。

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2438651A1 (fr) * 1978-10-12 1980-05-09 Glaxo Group Ltd Nouveaux derives d'indole utiles comme medicaments, procedes pour leur preparation et compositions pharmaceutiques les contenant
FR2488606A1 (fr) * 1980-08-12 1982-02-19 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
US4839377A (en) * 1980-08-12 1989-06-13 Glaxo Group Limited 5-substituted 3-aminoalkyl indoles

Also Published As

Publication number Publication date
DE2363608A1 (de) 1974-06-27
JPS4988868A (OSRAM) 1974-08-24
NL7316677A (OSRAM) 1974-06-25

Similar Documents

Publication Publication Date Title
IE41182L (en) Phenyl ethers, herbicide intermediates
ES422386A1 (es) Procedimiento para preparar esteres de acidos o-etil-s-n- propil-o-vinil-tionotiolfosforicos.
FR2024548A1 (en) Ortho-substd phenethylamines and medicaments
FR2028991A1 (fr) Anilides substitues
FR1602719A (en) Herbicidal diphenylether/pheny urea compos - ition
ES433186A1 (es) Procedimiento para preparar una composicion de alanina di- sustituida en n con propiedades herbicidas.
GB1081945A (en) Manufacture of quinazoline 3-oxides
FR2393802A1 (fr) Nouveaux derives de l'acide piperazinecarbodithioique, leur procede de preparation et leur application en therapeutique
FR2059979A1 (en) Subst n-benzyl tetrahydroisoquinolinesantiin
FR2296624A1 (fr) N-(trichloromethylthio, tetrachlorethylthio ou tetrachlorofluorethylthio)-halobenzoylanilides utiles comme fongicides
GB1447954A (en) Process for the preparation of 1,2,4-triazole derivative
GB1447346A (en) N-thiadiazolyl-2-carboxylic acid amides their preparation and their use as herbicides
CH503463A (de) Verwendung von 2-Hydroxybenzophenonen zur Bekämpfung schädlicher Mikroorganismen ausserhalb der Textilindustrie
FR2245284A1 (en) N-Aryl-N-methyl ureas as selective herbicides - for pre- and post-emergent use
FR2070092A1 (fr) Nouvelles bases de schiff et leur procede de preparation
GB1113972A (en) Improvements in or relating to aryloxy propanols and the manufacture thereof
FR2134197A1 (en) 2(4' (dithiane, dithiolane or dithiacycloheptane) phenyl)-acetic - acid derivs - antiinflammatories
FR2155831A1 (en) N,n'-dimethyl-n-benzothiazolyl -ureas - as herbicides
FR2071041A6 (en) 2,2-dihalo-1-phenyl-1-subst-ethanols -active as insecticides - and herbicides
GB1410925A (en) Pharmaceutical compositions containing 1-phenyl biguanides and a process for their production
FR2124164A1 (en) Phenyl pyridazonyl piperazines - analgesics hypotensives sedatives and antibacterials
CA450838A (en) Bis-(2,4-dialkylphenol)-4-alkyl phenol sulphides and salts thereof
FR2275457A1 (fr) Nouveaux derives de l'acide chrysanthemique
FR2040359A1 (fr) Procede d'emploi de derives oxaziniques pour la destruction de champignons phytopathogenes et composes nouveaux utilisables dans ce procede
FR2068346A5 (en) N-acyl 3,4-disubst-phenylalanine derivs

Legal Events

Date Code Title Description
ST Notification of lapse