FR2197577A1 - Hypocholesterolaemic, antiatheroma agents - 3,5-diiodo-4-(3-iodo-4-alkoxy-carbonyl phenoxy) phenylalkanoic acids, esters and salts - Google Patents
Hypocholesterolaemic, antiatheroma agents - 3,5-diiodo-4-(3-iodo-4-alkoxy-carbonyl phenoxy) phenylalkanoic acids, esters and saltsInfo
- Publication number
- FR2197577A1 FR2197577A1 FR7230781A FR7230781A FR2197577A1 FR 2197577 A1 FR2197577 A1 FR 2197577A1 FR 7230781 A FR7230781 A FR 7230781A FR 7230781 A FR7230781 A FR 7230781A FR 2197577 A1 FR2197577 A1 FR 2197577A1
- Authority
- FR
- France
- Prior art keywords
- hypocholesterolaemic
- day
- salts
- antiatheroma
- diiodo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Compounds of formula (I) are new: where n is 1 or 2; R is -CH2-, -CH2-CH2-, -CH-, -CH- R' and R2 are same or different H, CH3, C2H5 or C3H7, and their Li, Na, K, morpholine, ethanolamine, diethanolamine and triethanolamine salts. Hypocholesterolaemic, and antiatheromatous activity; they promote the metabolism of ethanol and acetaldehyde. LD50 orally in rats is 80-120 mg/kg. The compounds have similar pharmacological activity to 3,5,3'-triiodothyroacetic acid. One compound was given to rats on an atherogenic diet for 2 months; they showed no difference from control animals on normal diet at autopsy. Chickens on an atherogenic diet were given 0.8 mu g/kg. of (I) and were protected from cholesterolaemia. 0.5 to 15 mg/day orally; 0.25 to 5 mg/day rectally; 0.5 to 3 mg/day parenterally; 5 to 50 mg/day percutaneously.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7230781A FR2197577A1 (en) | 1972-08-30 | 1972-08-30 | Hypocholesterolaemic, antiatheroma agents - 3,5-diiodo-4-(3-iodo-4-alkoxy-carbonyl phenoxy) phenylalkanoic acids, esters and salts |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7230781A FR2197577A1 (en) | 1972-08-30 | 1972-08-30 | Hypocholesterolaemic, antiatheroma agents - 3,5-diiodo-4-(3-iodo-4-alkoxy-carbonyl phenoxy) phenylalkanoic acids, esters and salts |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2197577A1 true FR2197577A1 (en) | 1974-03-29 |
FR2197577B1 FR2197577B1 (en) | 1975-10-17 |
Family
ID=9103692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7230781A Granted FR2197577A1 (en) | 1972-08-30 | 1972-08-30 | Hypocholesterolaemic, antiatheroma agents - 3,5-diiodo-4-(3-iodo-4-alkoxy-carbonyl phenoxy) phenylalkanoic acids, esters and salts |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2197577A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1398024A3 (en) * | 1995-06-07 | 2004-12-15 | Karo Bio Ab | uses for thyroid hormones compounds |
WO2005009433A1 (en) * | 2003-07-24 | 2005-02-03 | Fernando Goglia | Use of 3,5 diiodothyronine as regulators of lipid metabolism |
-
1972
- 1972-08-30 FR FR7230781A patent/FR2197577A1/en active Granted
Non-Patent Citations (1)
Title |
---|
NEANT * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1398024A3 (en) * | 1995-06-07 | 2004-12-15 | Karo Bio Ab | uses for thyroid hormones compounds |
WO2005009433A1 (en) * | 2003-07-24 | 2005-02-03 | Fernando Goglia | Use of 3,5 diiodothyronine as regulators of lipid metabolism |
Also Published As
Publication number | Publication date |
---|---|
FR2197577B1 (en) | 1975-10-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |