FR2189025A1 - 3-Phenyl-3-(thien-2-yl)acrylamides - with analgesic, antiinflammatory, hypotensive, anticholinergic, antiulcer bronchodilator, spasmolytic and diuretic activity - Google Patents
3-Phenyl-3-(thien-2-yl)acrylamides - with analgesic, antiinflammatory, hypotensive, anticholinergic, antiulcer bronchodilator, spasmolytic and diuretic activityInfo
- Publication number
- FR2189025A1 FR2189025A1 FR7221888A FR7221888A FR2189025A1 FR 2189025 A1 FR2189025 A1 FR 2189025A1 FR 7221888 A FR7221888 A FR 7221888A FR 7221888 A FR7221888 A FR 7221888A FR 2189025 A1 FR2189025 A1 FR 2189025A1
- Authority
- FR
- France
- Prior art keywords
- spasmolytic
- antiulcer
- bronchodilator
- anticholinergic
- hypotensive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Cpds. of formula: and their acid-addn. salts where n is 0 or 1; R is alkylamino (C1-C4) or pyrrolidino, have analgesic, antiinflammatory, hypotensive, anticholinergic, bronchodilator, antiulcer, spasmolytic and diuretic activity. The LD50 orally in mice is 1100-1550 mg./kg. except for I (n = 1; R = pyrrolidino) which is non-toxic at 2 g./kg. orally. Clinical dose is 25-300 mg. orally 1-5 times daily; 1 or 2 suppositories daily each contg. 25-200 mg.; 1-100 mg. by injection once or twice daily.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7221888A FR2189025A1 (en) | 1972-06-16 | 1972-06-16 | 3-Phenyl-3-(thien-2-yl)acrylamides - with analgesic, antiinflammatory, hypotensive, anticholinergic, antiulcer bronchodilator, spasmolytic and diuretic activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7221888A FR2189025A1 (en) | 1972-06-16 | 1972-06-16 | 3-Phenyl-3-(thien-2-yl)acrylamides - with analgesic, antiinflammatory, hypotensive, anticholinergic, antiulcer bronchodilator, spasmolytic and diuretic activity |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2189025A1 true FR2189025A1 (en) | 1974-01-25 |
FR2189025B1 FR2189025B1 (en) | 1975-06-20 |
Family
ID=9100347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7221888A Granted FR2189025A1 (en) | 1972-06-16 | 1972-06-16 | 3-Phenyl-3-(thien-2-yl)acrylamides - with analgesic, antiinflammatory, hypotensive, anticholinergic, antiulcer bronchodilator, spasmolytic and diuretic activity |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2189025A1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2632010A (en) * | 1951-04-19 | 1953-03-17 | Parke Davis & Co | N-alkyl thiopheneacrylamides |
FR8198M (en) * | 1967-09-29 | 1970-09-14 | Delalande Sa |
-
1972
- 1972-06-16 FR FR7221888A patent/FR2189025A1/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2632010A (en) * | 1951-04-19 | 1953-03-17 | Parke Davis & Co | N-alkyl thiopheneacrylamides |
FR8198M (en) * | 1967-09-29 | 1970-09-14 | Delalande Sa |
Non-Patent Citations (1)
Title |
---|
CHIMICA THERAPEUTICA IV, 1969, PAGES 293-297 * |
Also Published As
Publication number | Publication date |
---|---|
FR2189025B1 (en) | 1975-06-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |