FR2175627A1 - Substd 3-(3-amino-2-hydroxypropoxy)-1-isoindolinones - anti-arrhythmi - Google Patents

Substd 3-(3-amino-2-hydroxypropoxy)-1-isoindolinones - anti-arrhythmi

Info

Publication number
FR2175627A1
FR2175627A1 FR7209207A FR7209207A FR2175627A1 FR 2175627 A1 FR2175627 A1 FR 2175627A1 FR 7209207 A FR7209207 A FR 7209207A FR 7209207 A FR7209207 A FR 7209207A FR 2175627 A1 FR2175627 A1 FR 2175627A1
Authority
FR
France
Prior art keywords
substd
opt
alkyl
same
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7209207A
Other languages
French (fr)
Other versions
FR2175627B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA filed Critical Rhone Poulenc SA
Priority to FR7209207A priority Critical patent/FR2175627A1/en
Priority to AR250934A priority patent/AR203996A1/en
Priority to AR247093A priority patent/AR203991A1/en
Priority to FR7303728A priority patent/FR2215951B2/fr
Priority to OA54846A priority patent/OA04294A/en
Priority to NLAANVRAGE7303291,A priority patent/NL168510C/en
Priority to FI756/73A priority patent/FI55029C/en
Priority to US341307A priority patent/US3898232A/en
Priority to AU53290/73A priority patent/AU467855B2/en
Priority to HURO711A priority patent/HU165990B/hu
Priority to JP2909773A priority patent/JPS5331865B2/ja
Priority to GB1226773A priority patent/GB1382770A/en
Priority to ZA731804A priority patent/ZA731804B/en
Priority to IE414/73A priority patent/IE37405B1/en
Priority to BE128837A priority patent/BE796828A/en
Priority to IL41788A priority patent/IL41788A/en
Priority to DK141473AA priority patent/DK136360B/en
Priority to CH108075A priority patent/CH568288A5/xx
Priority to NO1046/73A priority patent/NO140348C/en
Priority to SE7303641A priority patent/SE385477B/en
Priority to CH378773A priority patent/CH562791A5/xx
Priority to CA166,339A priority patent/CA976549A/en
Priority to LU67224A priority patent/LU67224A1/xx
Priority to SU1893605A priority patent/SU507233A3/en
Priority to ES412715A priority patent/ES412715A1/en
Priority to AT235073A priority patent/AT322544B/en
Priority to ES412714A priority patent/ES412714A1/en
Priority to YU711/73A priority patent/YU35768B/en
Priority to DE2313227A priority patent/DE2313227C3/en
Publication of FR2175627A1 publication Critical patent/FR2175627A1/en
Priority to SU2018656A priority patent/SU496730A3/en
Priority to US05/527,031 priority patent/US3987174A/en
Application granted granted Critical
Publication of FR2175627B1 publication Critical patent/FR2175627B1/fr
Priority to US05/669,730 priority patent/US4054654A/en
Priority to YU1969/79A priority patent/YU35769B/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

(A) Cmpds. of formula (I): Where Ar = Ph or heteroaryl (e.g. pyridyl or pyridazinyl) opt. substd. by one or two same or different hal, 1-4C alkyl, 1-4C alkoxy, CN, NO2 or CF3; X and Y are same or different H or 1-4C alkoxy or X+Y = OCH2O, and R' and R2 = same or different H or 1-4C alkyl, or NR'R2 forms a 5-6 membered ring, opt. contg. an O, S or another N atom, and opt. substd. by 1-4C alkyl. (B) Acid addn. salts of (I). Anti-arrhythmics. EXAMPLE 3-(2,3-epoxypropoxy) 2-phenyl 1-isoindolinone (19.7 g) was refluxed 26 hrs. in PriNH2 (50 ml), cooled, dild. with Pr2iO (100 ml), filtered, and recryst. from MeCN, giving 3-(3-isopropylamino-2-hydrox ypropoxy)-2-phenyl-1-isoindolinone (14.1 gms) m.pt. 98 degrees C.
FR7209207A 1972-03-16 1972-03-16 Substd 3-(3-amino-2-hydroxypropoxy)-1-isoindolinones - anti-arrhythmi Granted FR2175627A1 (en)

Priority Applications (33)

Application Number Priority Date Filing Date Title
FR7209207A FR2175627A1 (en) 1972-03-16 1972-03-16 Substd 3-(3-amino-2-hydroxypropoxy)-1-isoindolinones - anti-arrhythmi
AR250934A AR203996A1 (en) 1972-03-16 1973-01-01 PROCEDURE FOR PREPARING DERIVATIVES OF (HYDROXY-2-AMINO-3-PROPOXI) -3-ISOINDOLINONE-1
AR247093A AR203991A1 (en) 1972-03-16 1973-01-01 PROCEDURE FOR PREPARING DERIVATIVES OF (HYDROXY-2-AMINO-3-PROPOXI) -3-ISOINDOLINONE-1
FR7303728A FR2215951B2 (en) 1972-03-16 1973-02-02
OA54846A OA04294A (en) 1972-03-16 1973-03-06 New derivatives of isoindoline and their preparation process.
NLAANVRAGE7303291,A NL168510C (en) 1972-03-16 1973-03-08 PROCESS FOR THE PREPARATION OF A PREPARATION WITH AN ANTI-ARRHITICAL ACTION, IN WHICH AN ACTIVE SUBSTANCE IS FORMED FOR SUCH PREPARATIONS, PREPARED PREPARATIONS USING THIS PROCESS WITH A PROPERTY PROCESSED THROUGH A PROPER PRODUCT. USE IN THIS METHOD.
FI756/73A FI55029C (en) 1972-03-16 1973-03-13 FOERFARANDE FOER FRAMSTAELLNING AV NYA TERAPEUTISKT AKTIVA ISOINDOLINDERIVAT
AU53290/73A AU467855B2 (en) 1972-03-16 1973-03-14 Isoindoline derivatives
HURO711A HU165990B (en) 1972-03-16 1973-03-14
JP2909773A JPS5331865B2 (en) 1972-03-16 1973-03-14
GB1226773A GB1382770A (en) 1972-03-16 1973-03-14 Isoindoline derivatives
ZA731804A ZA731804B (en) 1972-03-16 1973-03-14 Isoindoline derivatives
IE414/73A IE37405B1 (en) 1972-03-16 1973-03-14 Isoindoline derivatives
US341307A US3898232A (en) 1972-03-16 1973-03-14 Isoindolin-1-one derivatives
CH108075A CH568288A5 (en) 1972-03-16 1973-03-15
DK141473AA DK136360B (en) 1972-03-16 1973-03-15 Analogous process for the preparation of isoindoline derivatives.
BE128837A BE796828A (en) 1972-03-16 1973-03-15 NEW ISOINDOLINE DERIVATIVES THEIR PREPARATION AND THE MEDICINAL COMPOSITIONS CONTAINING THEM
NO1046/73A NO140348C (en) 1972-03-16 1973-03-15 ANALOGICAL PROCEDURES FOR THE PREPARATION OF NEW THERAPEUTIC ACTIVE 3- (AMINO-2-HYDROXYPROPOXY) -ISOINDOLIN-1-ON COMPOUNDS
SE7303641A SE385477B (en) 1972-03-16 1973-03-15 PROCEDURE FOR PREPARING NEW ISOINDOLINE DERIVATIVES
CH378773A CH562791A5 (en) 1972-03-16 1973-03-15
CA166,339A CA976549A (en) 1972-03-16 1973-03-15 Derives de l'isoindoline, leur preparation et les compositions medicinales qui les contiennent
LU67224A LU67224A1 (en) 1972-03-16 1973-03-15
SU1893605A SU507233A3 (en) 1972-03-16 1973-03-15 The method of obtaining derivatives of isoindoline or their salts
IL41788A IL41788A (en) 1972-03-16 1973-03-15 Isoindoline derivatives,processes for their preparation and pharmaceutical compositions containing them
ES412715A ES412715A1 (en) 1972-03-16 1973-03-16 Isoindolin-1-one derivatives
AT235073A AT322544B (en) 1972-03-16 1973-03-16 PROCESS FOR THE PRODUCTION OF NEW ISOINDOLINONE DERIVATIVES AND THEIR SALT
ES412714A ES412714A1 (en) 1972-03-16 1973-03-16 Isoindolin-1-one derivatives
YU711/73A YU35768B (en) 1972-03-16 1973-03-16 Process for obtaining novel isoindoline derivatives
DE2313227A DE2313227C3 (en) 1972-03-16 1973-03-16 Isoindolin- (l) -one derivatives, their salts, processes for their preparation and pharmaceutical compositions
SU2018656A SU496730A3 (en) 1972-03-16 1974-04-29 The method of obtaining derivatives of isoindoline or their salts
US05/527,031 US3987174A (en) 1972-03-16 1974-11-25 Isoindolin-1-one derivatives
US05/669,730 US4054654A (en) 1972-03-16 1976-03-23 Isoindolin-1-one derivatives
YU1969/79A YU35769B (en) 1972-03-16 1979-08-13 Process for obtaining novel isoindoline derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7209207A FR2175627A1 (en) 1972-03-16 1972-03-16 Substd 3-(3-amino-2-hydroxypropoxy)-1-isoindolinones - anti-arrhythmi

Publications (2)

Publication Number Publication Date
FR2175627A1 true FR2175627A1 (en) 1973-10-26
FR2175627B1 FR2175627B1 (en) 1975-11-28

Family

ID=9095305

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7209207A Granted FR2175627A1 (en) 1972-03-16 1972-03-16 Substd 3-(3-amino-2-hydroxypropoxy)-1-isoindolinones - anti-arrhythmi

Country Status (2)

Country Link
FR (1) FR2175627A1 (en)
ZA (1) ZA731804B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2343198A (en) * 1940-04-03 1944-02-29 Abbott Lab Nu-alkamine substituted derivatives of phthalimide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2343198A (en) * 1940-04-03 1944-02-29 Abbott Lab Nu-alkamine substituted derivatives of phthalimide

Also Published As

Publication number Publication date
FR2175627B1 (en) 1975-11-28
ZA731804B (en) 1973-12-19

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Legal Events

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