FR2166043A2 - 4-amino-quinazoline derivs - with anti-angina anti-arrhythmic props - Google Patents

4-amino-quinazoline derivs - with anti-angina anti-arrhythmic props

Info

Publication number
FR2166043A2
FR2166043A2 FR7246287A FR7246287A FR2166043A2 FR 2166043 A2 FR2166043 A2 FR 2166043A2 FR 7246287 A FR7246287 A FR 7246287A FR 7246287 A FR7246287 A FR 7246287A FR 2166043 A2 FR2166043 A2 FR 2166043A2
Authority
FR
France
Prior art keywords
arrhythmic
angina
props
amino
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7246287A
Other languages
French (fr)
Other versions
FR2166043B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2166043A2 publication Critical patent/FR2166043A2/en
Application granted granted Critical
Publication of FR2166043B2 publication Critical patent/FR2166043B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Title cpds have formula: (where Ro = 1-4C alkyl, Y,Y1,Y2 = H, 1-3C alkyl or 1-3C alkoxy, >=1 of the gps. being other than alkyl or Y and Y1 together = methylenedioxy and Y2 = H, R, R1 = H, 1-4C alkyl, -CH2-(CH2)n-ONO2, -CH2-(CHR2)n-ONO2 (Gp B), -CH2-(CH2)z-N -CH2(CH2)x-O-NO2 2 or R and R1 together with the N atom = -N N-CH2-(CH2)z-O-NO2, R2 = H, -(CH2)m-CH3 or -(CH2)yONO2, m = 0-4, x,y,z, = 1-4, and n = 1-6 (pref. 3, 4, or 5), with the conditions (i) there are 1 or 2 -O-NO2 gps. present (ii) when R or R1 = Gp B the other = H or alkyl (iii) in each Gp B only one R2 substituent is not = H (iv) n + m =6 and (v) n + y =6, including their acid addn. salts.
FR7246287A 1971-12-27 1972-12-27 4-amino-quinazoline derivs - with anti-angina anti-arrhythmic props Granted FR2166043A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21278471A 1971-12-27 1971-12-27

Publications (2)

Publication Number Publication Date
FR2166043A2 true FR2166043A2 (en) 1973-08-10
FR2166043B2 FR2166043B2 (en) 1976-07-02

Family

ID=22792411

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7246287A Granted FR2166043A2 (en) 1971-12-27 1972-12-27 4-amino-quinazoline derivs - with anti-angina anti-arrhythmic props

Country Status (5)

Country Link
JP (1) JPS4872180A (en)
BE (1) BE793371A (en)
DE (1) DE2262282A1 (en)
FR (1) FR2166043A2 (en)
NL (1) NL7217584A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1460389A (en) * 1974-07-25 1977-01-06 Pfizer Ltd 4-substituted quinazoline cardiac stimulants

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3517005A (en) * 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
FR2081329A2 (en) * 1969-12-05 1971-12-03 Sandoz Sa

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3517005A (en) * 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
FR2081329A2 (en) * 1969-12-05 1971-12-03 Sandoz Sa

Also Published As

Publication number Publication date
DE2262282A1 (en) 1973-07-12
JPS4872180A (en) 1973-09-29
NL7217584A (en) 1973-06-29
FR2166043B2 (en) 1976-07-02
BE793371A (en) 1973-06-27

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