FR2162562A1 - Pyrrolidinylmethyl benzamide prepn - by reaction of a pyrrolidinylmethylamine with a benzoic acid mixed anhydride - Google Patents
Pyrrolidinylmethyl benzamide prepn - by reaction of a pyrrolidinylmethylamine with a benzoic acid mixed anhydrideInfo
- Publication number
- FR2162562A1 FR2162562A1 FR7243651A FR7243651A FR2162562A1 FR 2162562 A1 FR2162562 A1 FR 2162562A1 FR 7243651 A FR7243651 A FR 7243651A FR 7243651 A FR7243651 A FR 7243651A FR 2162562 A1 FR2162562 A1 FR 2162562A1
- Authority
- FR
- France
- Prior art keywords
- reaction
- prepn
- pyrrolidinylmethylamine
- pyrrolidinylmethyl
- benzamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000006243 chemical reaction Methods 0.000 title abstract 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 title 2
- 239000005711 Benzoic acid Substances 0.000 title 1
- 150000008064 anhydrides Chemical class 0.000 title 1
- 235000010233 benzoic acid Nutrition 0.000 title 1
- ZFRCAYVKWJHAMV-UHFFFAOYSA-N n-(pyrrolidin-1-ylmethyl)benzamide Chemical compound C=1C=CC=CC=1C(=O)NCN1CCCC1 ZFRCAYVKWJHAMV-UHFFFAOYSA-N 0.000 title 1
- VMPYTOIPVPQDNX-UHFFFAOYSA-N pyrrolidin-1-ylmethanamine Chemical compound NCN1CCCC1 VMPYTOIPVPQDNX-UHFFFAOYSA-N 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- SQAILWDRVDGLGY-UHFFFAOYSA-N 2-methoxy-5-sulfamoylbenzoic acid Chemical compound COC1=CC=C(S(N)(=O)=O)C=C1C(O)=O SQAILWDRVDGLGY-UHFFFAOYSA-N 0.000 abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 1
- 208000012886 Vertigo Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000561 anti-psychotic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001079 digestive effect Effects 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 abstract 1
- 231100000029 gastro-duodenal ulcer Toxicity 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 231100000889 vertigo Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT3218171 | 1971-12-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2162562A1 true FR2162562A1 (en) | 1973-07-20 |
| FR2162562B1 FR2162562B1 (enrdf_load_stackoverflow) | 1976-07-02 |
Family
ID=11234973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7243651A Granted FR2162562A1 (en) | 1971-12-09 | 1972-12-07 | Pyrrolidinylmethyl benzamide prepn - by reaction of a pyrrolidinylmethylamine with a benzoic acid mixed anhydride |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS4864066A (enrdf_load_stackoverflow) |
| ES (1) | ES408918A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2162562A1 (enrdf_load_stackoverflow) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1472025A (fr) * | 1964-01-13 | 1967-03-10 | Merck & Co Inc | Procédé de fabrication de nouvelles benzamides hétérocycliques |
-
1972
- 1972-05-29 JP JP5258572A patent/JPS4864066A/ja active Pending
- 1972-11-23 ES ES408918A patent/ES408918A1/es not_active Expired
- 1972-12-07 FR FR7243651A patent/FR2162562A1/fr active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1472025A (fr) * | 1964-01-13 | 1967-03-10 | Merck & Co Inc | Procédé de fabrication de nouvelles benzamides hétérocycliques |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS4864066A (enrdf_load_stackoverflow) | 1973-09-05 |
| ES408918A1 (es) | 1975-10-16 |
| FR2162562B1 (enrdf_load_stackoverflow) | 1976-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |