FR2151043A1 - 3,4-dihydro-2h-isoquinoline-1-ones - useful for lowering of cholesterol - and triglyceride level in serum - Google Patents

3,4-dihydro-2h-isoquinoline-1-ones - useful for lowering of cholesterol - and triglyceride level in serum

Info

Publication number
FR2151043A1
FR2151043A1 FR7230950A FR7230950A FR2151043A1 FR 2151043 A1 FR2151043 A1 FR 2151043A1 FR 7230950 A FR7230950 A FR 7230950A FR 7230950 A FR7230950 A FR 7230950A FR 2151043 A1 FR2151043 A1 FR 2151043A1
Authority
FR
France
Prior art keywords
phenyl
alkyl
isoquinoline
cholesterol
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7230950A
Other languages
English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Farbwerke Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG, Farbwerke Hoechst AG filed Critical Hoechst AG
Publication of FR2151043A1 publication Critical patent/FR2151043A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/213—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C49/215—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR7230950A 1971-09-01 1972-08-31 3,4-dihydro-2h-isoquinoline-1-ones - useful for lowering of cholesterol - and triglyceride level in serum Withdrawn FR2151043A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2143744A DE2143744A1 (de) 1971-09-01 1971-09-01 3,4-dihydro-2h-isochinolin-1-one und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
FR2151043A1 true FR2151043A1 (en) 1973-04-13

Family

ID=5818353

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7230950A Withdrawn FR2151043A1 (en) 1971-09-01 1972-08-31 3,4-dihydro-2h-isoquinoline-1-ones - useful for lowering of cholesterol - and triglyceride level in serum

Country Status (12)

Country Link
JP (1) JPS4834886A (xx)
AU (1) AU4610372A (xx)
BE (1) BE788322A (xx)
BG (3) BG19375A3 (xx)
CA (1) CA983039A (xx)
DD (1) DD102147A5 (xx)
DE (1) DE2143744A1 (xx)
FR (1) FR2151043A1 (xx)
HU (1) HU165204B (xx)
IL (1) IL40249A0 (xx)
NL (1) NL7211626A (xx)
ZA (1) ZA725996B (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2385720A1 (fr) * 1977-03-29 1978-10-27 Parcor Thieno(2,3-c) et (3,2-c) pyridines, leur procede de preparation et leur application en therapeutique

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5650682B2 (xx) * 1974-03-25 1981-12-01
DE2438966A1 (de) * 1974-08-14 1976-03-04 Hoechst Ag Basisch substituierte 3,,4-dihydro2h-isochinolin-1-one und verfahren zu ihrer herstellung
DE3443994A1 (de) * 1984-06-14 1985-12-19 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von gegebenenfalls substituierten benz(c,d)-indol-2-onen
JP5498168B2 (ja) * 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
AR092742A1 (es) * 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CN110452216B (zh) 2014-04-02 2022-08-26 英特穆恩公司 抗纤维化吡啶酮类

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2385720A1 (fr) * 1977-03-29 1978-10-27 Parcor Thieno(2,3-c) et (3,2-c) pyridines, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
IL40249A0 (en) 1972-10-29
BG19375A3 (xx) 1975-06-15
DE2143744A1 (de) 1973-03-08
HU165204B (xx) 1974-07-27
CA983039A (en) 1976-02-03
BG20410A3 (xx) 1975-11-05
NL7211626A (xx) 1973-03-05
DD102147A5 (xx) 1973-12-05
BG19799A3 (xx) 1975-10-10
AU4610372A (en) 1974-03-07
ZA725996B (en) 1973-06-27
BE788322A (fr) 1973-03-01
JPS4834886A (xx) 1973-05-22

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Legal Events

Date Code Title Description
ST Notification of lapse