FR2117836A1 - (2)-Hydroxy and (2,3)-dihydroxy-(5)-carbalkoxy-benzyloxyamines - antihistamines, antiserotonins and antidopamines - Google Patents
(2)-Hydroxy and (2,3)-dihydroxy-(5)-carbalkoxy-benzyloxyamines - antihistamines, antiserotonins and antidopaminesInfo
- Publication number
- FR2117836A1 FR2117836A1 FR7126314A FR7126314A FR2117836A1 FR 2117836 A1 FR2117836 A1 FR 2117836A1 FR 7126314 A FR7126314 A FR 7126314A FR 7126314 A FR7126314 A FR 7126314A FR 2117836 A1 FR2117836 A1 FR 2117836A1
- Authority
- FR
- France
- Prior art keywords
- hydroxy
- dihydroxy
- benzyloxyamines
- antiserotonins
- antidopamines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002973 anti-dopamine Effects 0.000 title abstract 2
- 230000000794 anti-serotonin Effects 0.000 title abstract 2
- 239000000739 antihistaminic agent Substances 0.000 title abstract 2
- 229940125715 antihistaminic agent Drugs 0.000 title 1
- -1 benzoic ester Chemical class 0.000 abstract 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000003420 antiserotonin agent Substances 0.000 abstract 1
- 239000003954 decarboxylase inhibitor Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910000039 hydrogen halide Inorganic materials 0.000 abstract 1
- 239000012433 hydrogen halide Substances 0.000 abstract 1
- 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 abstract 1
- 125000000612 phthaloyl group Chemical group C(C=1C(C(=O)*)=CC=CC1)(=O)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Title cpds. of formula (I) and salts of I, CH2ONH2 where R' = Me, or Et, and X = H or OH, have anti-histamine, anti-serotonin, and anti-dopamine activity, being both specific and non-specific decarboxylase inhibitors I are prepd. by (a) halomethylating a 3-hydroxy or 3,4-dihydroxy benzoic ester with HCHO and hydrogen halide (b) replacing the halogen with R2R3NO, where R2 = H and R3 = CO2Et or R2+R3 = phthaloyl, isopropylidene, or 2-hydroxybenzylidene, and (c) removing the N-substits with N2H4 or HCl.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUGO001152 | 1970-12-14 | ||
| HUGI001152 | 1970-12-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2117836A1 true FR2117836A1 (en) | 1972-07-28 |
| FR2117836B1 FR2117836B1 (en) | 1974-09-06 |
Family
ID=26318466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7126314A Granted FR2117836A1 (en) | 1970-12-14 | 1971-07-19 | (2)-Hydroxy and (2,3)-dihydroxy-(5)-carbalkoxy-benzyloxyamines - antihistamines, antiserotonins and antidopamines |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2117836A1 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB989557A (en) * | 1962-05-15 | 1965-04-22 | Smith & Nephew | Hydroxylamine derivative and processes for making it |
-
1971
- 1971-07-19 FR FR7126314A patent/FR2117836A1/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB989557A (en) * | 1962-05-15 | 1965-04-22 | Smith & Nephew | Hydroxylamine derivative and processes for making it |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2117836B1 (en) | 1974-09-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |