FR2116313A1 - Protokylol pamoate - with long-acting bronchodilator activity - Google Patents

Protokylol pamoate - with long-acting bronchodilator activity

Info

Publication number
FR2116313A1
FR2116313A1 FR7044058A FR7044058A FR2116313A1 FR 2116313 A1 FR2116313 A1 FR 2116313A1 FR 7044058 A FR7044058 A FR 7044058A FR 7044058 A FR7044058 A FR 7044058A FR 2116313 A1 FR2116313 A1 FR 2116313A1
Authority
FR
France
Prior art keywords
protokylol
pamoate
long
bronchodilator activity
acting bronchodilator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7044058A
Other languages
French (fr)
Other versions
FR2116313B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7044058A priority Critical patent/FR2116313A1/en
Publication of FR2116313A1 publication Critical patent/FR2116313A1/en
Application granted granted Critical
Publication of FR2116313B1 publication Critical patent/FR2116313B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
    • C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Methylene bis - hydroxy-3-naphthoate-2 -4- of N (dihydroxy-3,4-phenyl)-2-hydroxy-2-ethyl , N methyl-1(methylene-dioxy-3,4-phenyl)-2-ethyl amine, (or protokylol pamoate) of formula- with bronchodilator activity lasting twice as long as that of protokylol hydrochloride. Useful for treating bronchitis and amphysema at doses of 50 mg/day orally or 100 mg/day rectally. Prepd by adding a soln of pamoic acid to a soln of protokylol hydrochloride.
FR7044058A 1970-12-08 1970-12-08 Protokylol pamoate - with long-acting bronchodilator activity Granted FR2116313A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7044058A FR2116313A1 (en) 1970-12-08 1970-12-08 Protokylol pamoate - with long-acting bronchodilator activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7044058A FR2116313A1 (en) 1970-12-08 1970-12-08 Protokylol pamoate - with long-acting bronchodilator activity

Publications (2)

Publication Number Publication Date
FR2116313A1 true FR2116313A1 (en) 1972-07-13
FR2116313B1 FR2116313B1 (en) 1974-03-22

Family

ID=9065396

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7044058A Granted FR2116313A1 (en) 1970-12-08 1970-12-08 Protokylol pamoate - with long-acting bronchodilator activity

Country Status (1)

Country Link
FR (1) FR2116313A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472427A (en) * 1980-12-23 1984-09-18 Merck & Co., Inc. (Aralkylamino-2-OR-propoxy)heterocyclic compounds
CN109134352A (en) * 2018-09-21 2019-01-04 合肥锐思生物医药有限公司 A method of preparing slightly solubility compound or its solvate

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472427A (en) * 1980-12-23 1984-09-18 Merck & Co., Inc. (Aralkylamino-2-OR-propoxy)heterocyclic compounds
CN109134352A (en) * 2018-09-21 2019-01-04 合肥锐思生物医药有限公司 A method of preparing slightly solubility compound or its solvate

Also Published As

Publication number Publication date
FR2116313B1 (en) 1974-03-22

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Legal Events

Date Code Title Description
ST Notification of lapse