FR2104959A2 - Vincamine process - Google Patents
Vincamine processInfo
- Publication number
- FR2104959A2 FR2104959A2 FR7032889A FR7032889A FR2104959A2 FR 2104959 A2 FR2104959 A2 FR 2104959A2 FR 7032889 A FR7032889 A FR 7032889A FR 7032889 A FR7032889 A FR 7032889A FR 2104959 A2 FR2104959 A2 FR 2104959A2
- Authority
- FR
- France
- Prior art keywords
- give
- oxo
- treated
- vincamine
- homoeburane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 title abstract 4
- RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002726 vincamine Drugs 0.000 title abstract 2
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 230000011987 methylation Effects 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (28)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7032889A FR2104959A2 (en) | 1970-09-10 | 1970-09-10 | Vincamine process |
| US00126929A US3770724A (en) | 1970-03-31 | 1971-03-22 | Process for preparing pentacyclic alkaloids |
| IL36474A IL36474A (en) | 1970-03-31 | 1971-03-23 | Process for preparing pentacyclic alkaloids of the eburnamonine-vincamine series and novel e-homoeburnanes |
| PL1971147087A PL83152B1 (en) | 1970-03-31 | 1971-03-23 | Process for preparing pentacyclic alkaloids[us3770724a] |
| CH422071A CH546777A (fr) | 1970-03-31 | 1971-03-23 | Procede de preparation d'alcaloides pentacycliques. |
| HURO609A HU163769B (OSRAM) | 1970-03-31 | 1971-03-25 | |
| BE765006A BE765006A (fr) | 1970-03-31 | 1971-03-30 | Procede de preparation d'alcaloides pentacycliques |
| SU711633905A SU505365A3 (ru) | 1970-03-31 | 1971-03-30 | Способ полуучени п тициклических алкалоидов |
| CA109157A CA937570A (en) | 1970-03-31 | 1971-03-30 | Procede de preparation de la vincamine racemique ou optiquement active |
| SE7104214A SE386179B (sv) | 1970-03-31 | 1971-03-31 | Sett att framstella vinkamin. |
| NL7104275.A NL158497B (nl) | 1970-03-31 | 1971-03-31 | Werkwijze voor de bereiding van vincamine of isovincamine. |
| ATA2739/71A AT309699B (de) | 1970-03-31 | 1971-03-31 | Verfahren zur herstellung pentacyclischer alkaloide |
| DE19712167043 DE2167043A1 (de) | 1970-03-31 | 1971-03-31 | Verfahren zur herstellung von optisch aktivem cis-1,2,3,4,6,7,12,12b-octahydro- 1-aethyl-1-carbomethoxyaethyl-indolo eckige klammer auf 2,3-a eckige klammer zu chinolizin |
| SE7405749A SE390414B (sv) | 1970-03-31 | 1971-03-31 | 14,15-dioxo-e-homo-eburnaner som mellanprodukt for framstellning av vinkamin |
| JP46018828A JPS5144960B1 (OSRAM) | 1970-03-31 | 1971-03-31 | |
| DK153171A DK149345C (da) | 1970-03-31 | 1971-03-31 | Fremgangsmaade til fremstilling af d,l-vincamin eller d,l-isovincamin eller de optiske antipoder deraf |
| DE2115718A DE2115718C3 (de) | 1970-03-31 | 1971-03-31 | Verfahren zur Herstellung von Vincamin und Isovincamin |
| DE2167044A DE2167044C2 (de) | 1970-03-31 | 1971-03-31 | E-homo-eburnanderivate |
| GB2578671*A GB1351262A (en) | 1970-03-31 | 1971-04-19 | Quinolizine derivatives |
| GB2578671*A GB1351263A (en) | 1970-03-31 | 1971-04-19 | Eburnane derivatives |
| GB2578671*A GB1351261A (en) | 1970-03-31 | 1971-04-19 | Preparation of vincamine alkaloids |
| ES394892A ES394892A2 (es) | 1970-09-10 | 1971-09-08 | Procedimiento de preparacion de alcaloides pentaciclicos. |
| AT430772A AT336806B (de) | 1970-09-10 | 1972-05-17 | Verfahren zur herstellung eines neuen enantiomers des cis-1,2,3,4,6,7-12,12b-octahydro-1-athyl-1-carbomethoxyathyl-indolo-(2,3-a)-chinolizins |
| CA153,612A CA979452A (en) | 1970-03-31 | 1972-10-10 | E-homo-eburnanes |
| DK633373A DK136475B (da) | 1970-03-31 | 1973-11-23 | Dioxoforbindelse til brug som mellemprodukt til fremstilling af vincamin og isovincamin, samt fremgangsmåde til fremstilling af denne dioxoforbindelse. |
| JP12333275A JPS5337360B2 (OSRAM) | 1970-03-31 | 1975-10-15 | |
| JP50123333A JPS5227160B2 (OSRAM) | 1970-03-31 | 1975-10-15 | |
| IT8048032A IT8048032A0 (it) | 1970-03-31 | 1980-02-28 | Procedimento per la produzione di alcaloidi pentaciclici |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7032889A FR2104959A2 (en) | 1970-09-10 | 1970-09-10 | Vincamine process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2104959A2 true FR2104959A2 (en) | 1972-04-28 |
| FR2104959B2 FR2104959B2 (OSRAM) | 1974-02-01 |
Family
ID=9061144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7032889A Granted FR2104959A2 (en) | 1970-03-31 | 1970-09-10 | Vincamine process |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES394892A2 (OSRAM) |
| FR (1) | FR2104959A2 (OSRAM) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2206090A1 (en) * | 1972-11-16 | 1974-06-07 | Omnium Chimique Sa | Homovincamone-contg. medicaments - with vasodilating, spasmolytic anti-arrhythmic and anti-ischaemic properties |
| FR2431496A1 (fr) * | 1978-07-12 | 1980-02-15 | Richter Gedeon Vegyeszet | Procede pour la preparation d'esters d'acide 10-bromo-vincaminique et de composes analogues |
| FR2454808A1 (fr) * | 1979-04-26 | 1980-11-21 | Roussel Uclaf | Application a titre de medicaments d'oximes derivees du e-homo eburnane, oximes derivees du e-homo eburnane et preparation |
| FR2492380A1 (en) * | 1980-10-17 | 1982-04-23 | Richter Gedeon Vegyeszet | Optical antipodes of 14-oxo-E-homo-eburnane derivs. - useful as intermediates for cerebral vasodilators and their multistage prepn. from n-halo-pentanoyl-tryptophan derivs. |
-
1970
- 1970-09-10 FR FR7032889A patent/FR2104959A2/fr active Granted
-
1971
- 1971-09-08 ES ES394892A patent/ES394892A2/es not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2206090A1 (en) * | 1972-11-16 | 1974-06-07 | Omnium Chimique Sa | Homovincamone-contg. medicaments - with vasodilating, spasmolytic anti-arrhythmic and anti-ischaemic properties |
| FR2431496A1 (fr) * | 1978-07-12 | 1980-02-15 | Richter Gedeon Vegyeszet | Procede pour la preparation d'esters d'acide 10-bromo-vincaminique et de composes analogues |
| FR2454808A1 (fr) * | 1979-04-26 | 1980-11-21 | Roussel Uclaf | Application a titre de medicaments d'oximes derivees du e-homo eburnane, oximes derivees du e-homo eburnane et preparation |
| FR2492380A1 (en) * | 1980-10-17 | 1982-04-23 | Richter Gedeon Vegyeszet | Optical antipodes of 14-oxo-E-homo-eburnane derivs. - useful as intermediates for cerebral vasodilators and their multistage prepn. from n-halo-pentanoyl-tryptophan derivs. |
Also Published As
| Publication number | Publication date |
|---|---|
| ES394892A2 (es) | 1977-07-01 |
| FR2104959B2 (OSRAM) | 1974-02-01 |
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