FR2100978A1 - Derives acyles de l'insuline et leur preparation - Google Patents
Derives acyles de l'insuline et leur preparationInfo
- Publication number
- FR2100978A1 FR2100978A1 FR7128240A FR7128240A FR2100978A1 FR 2100978 A1 FR2100978 A1 FR 2100978A1 FR 7128240 A FR7128240 A FR 7128240A FR 7128240 A FR7128240 A FR 7128240A FR 2100978 A1 FR2100978 A1 FR 2100978A1
- Authority
- FR
- France
- Prior art keywords
- substd
- insulin
- radical
- phenyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
- 102000004877 Insulin Human genes 0.000 title abstract 3
- 108090001061 Insulin Proteins 0.000 title abstract 3
- 229940125396 insulin Drugs 0.000 title abstract 3
- 125000002252 acyl group Chemical group 0.000 title abstract 2
- -1 phenoxy, benzyloxy Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical group O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
- 150000001371 alpha-amino acids Chemical class 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702038121 DE2038121A1 (de) | 1970-07-31 | 1970-07-31 | Acylderivate des Insulins und Verfahren zu ihrer Herstellung |
| DE19702042299 DE2042299A1 (en) | 1970-08-26 | 1970-08-26 | Acyl derivs of insulin - with modified solubility |
| DE19712120268 DE2120268A1 (en) | 1971-04-26 | 1971-04-26 | Acyl derivs of insulin - with modified solubility |
| DE19712120269 DE2120269A1 (en) | 1971-04-26 | 1971-04-26 | Acyl derivs of insulin - with modified solubility |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2100978A1 true FR2100978A1 (fr) | 1972-03-24 |
Family
ID=27431111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7128240A Withdrawn FR2100978A1 (fr) | 1970-07-31 | 1971-08-02 | Derives acyles de l'insuline et leur preparation |
Country Status (7)
| Country | Link |
|---|---|
| AR (1) | AR194081A1 (OSRAM) |
| AU (1) | AU3176271A (OSRAM) |
| BE (1) | BE770758A (OSRAM) |
| DD (1) | DD95389A5 (OSRAM) |
| FR (1) | FR2100978A1 (OSRAM) |
| IL (1) | IL37412A0 (OSRAM) |
| NL (1) | NL7110277A (OSRAM) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2163617A1 (OSRAM) * | 1971-12-15 | 1973-07-27 | Hoechst Ag | |
| EP0013568A1 (de) * | 1979-01-13 | 1980-07-23 | Hoechst Aktiengesellschaft | Neue sulfonierte Insuline und Verfahren zu ihrer Herstellung |
| EP0017938A1 (en) * | 1979-04-13 | 1980-10-29 | Shionogi & Co., Ltd. | Process for preparing a B30-threonine insulin |
-
1971
- 1971-07-26 NL NL7110277A patent/NL7110277A/xx unknown
- 1971-07-29 AU AU31762/71A patent/AU3176271A/en not_active Expired
- 1971-07-29 DD DD156819A patent/DD95389A5/xx unknown
- 1971-07-29 AR AR237076A patent/AR194081A1/es active
- 1971-07-29 IL IL37412A patent/IL37412A0/xx unknown
- 1971-07-30 BE BE770758A patent/BE770758A/xx unknown
- 1971-08-02 FR FR7128240A patent/FR2100978A1/fr not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2163617A1 (OSRAM) * | 1971-12-15 | 1973-07-27 | Hoechst Ag | |
| EP0013568A1 (de) * | 1979-01-13 | 1980-07-23 | Hoechst Aktiengesellschaft | Neue sulfonierte Insuline und Verfahren zu ihrer Herstellung |
| EP0017938A1 (en) * | 1979-04-13 | 1980-10-29 | Shionogi & Co., Ltd. | Process for preparing a B30-threonine insulin |
Also Published As
| Publication number | Publication date |
|---|---|
| AR194081A1 (es) | 1973-06-22 |
| AU3176271A (en) | 1973-02-01 |
| DD95389A5 (OSRAM) | 1973-02-05 |
| NL7110277A (OSRAM) | 1972-02-02 |
| IL37412A0 (en) | 1971-10-20 |
| BE770758A (fr) | 1972-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Withdrawal of published application |