FR2091396A5 - Dopa optical resolution by selective crystallization from superstaura - Google Patents
Dopa optical resolution by selective crystallization from superstauraInfo
- Publication number
- FR2091396A5 FR2091396A5 FR7116770A FR7116770A FR2091396A5 FR 2091396 A5 FR2091396 A5 FR 2091396A5 FR 7116770 A FR7116770 A FR 7116770A FR 7116770 A FR7116770 A FR 7116770A FR 2091396 A5 FR2091396 A5 FR 2091396A5
- Authority
- FR
- France
- Prior art keywords
- isomer
- dopa
- supersatd
- soln
- superstaura
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The optical isomers of DL-(3,4-dihydroxyphenyl)alanine (dopa) are produced by preparing a supersatd. acidic to neutral solution of dopa which contains an excess of one of the two optical isomers and, after partial crystallisation has taken place, isolating the precipitated isomer by conventional methods. The isomer which is present in excess crystallises selectively from the supersatd. soln., and if the crystallisation is interrupted at an appropriate point may be isolated in pure form. One advantageous way of carrying out the procedure is to seed a supersatd. soln. of DL-dopa with crystals of the desired isomer. After separation of the crystallised isomer there is obtained a soln. in which the other isomer predominates, and this soln. can be supersatd. and the procedure repeated for this other isomer. L-Dopa is of use in the treatment of Parkinsonism, but the D-isomer is inactive.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4050870A JPS5136260B1 (en) | 1970-05-14 | 1970-05-14 | |
| JP6027270A JPS5136261B1 (en) | 1970-07-11 | 1970-07-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2091396A5 true FR2091396A5 (en) | 1972-01-14 |
Family
ID=26379971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7116770A Expired FR2091396A5 (en) | 1970-05-14 | 1971-05-10 | Dopa optical resolution by selective crystallization from superstaura |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE2123114A1 (en) |
| FR (1) | FR2091396A5 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5518905A (en) * | 1993-07-30 | 1996-05-21 | Ajinomoto Co., Inc. | Method for producing L-3,4-dihydroxyphenylalanine by precipitation of anhydrous crystals |
-
1971
- 1971-05-10 FR FR7116770A patent/FR2091396A5/en not_active Expired
- 1971-05-10 DE DE19712123114 patent/DE2123114A1/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5518905A (en) * | 1993-07-30 | 1996-05-21 | Ajinomoto Co., Inc. | Method for producing L-3,4-dihydroxyphenylalanine by precipitation of anhydrous crystals |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2123114A1 (en) | 1971-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |