FR2088087A1 - Aminoalkanoic acid benzhydrylamides - with analgesic diuretic spasmolytic antitussive activity - Google Patents
Aminoalkanoic acid benzhydrylamides - with analgesic diuretic spasmolytic antitussive activityInfo
- Publication number
- FR2088087A1 FR2088087A1 FR7017832A FR7017832A FR2088087A1 FR 2088087 A1 FR2088087 A1 FR 2088087A1 FR 7017832 A FR7017832 A FR 7017832A FR 7017832 A FR7017832 A FR 7017832A FR 2088087 A1 FR2088087 A1 FR 2088087A1
- Authority
- FR
- France
- Prior art keywords
- diuretic
- analgesic
- activity
- acid
- benzhydrylamides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002934 diuretic Substances 0.000 title abstract 4
- 230000000202 analgesic effect Effects 0.000 title abstract 3
- 230000000954 anitussive effect Effects 0.000 title abstract 3
- 230000001882 diuretic effect Effects 0.000 title abstract 2
- 230000002048 spasmolytic effect Effects 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 239000000812 cholinergic antagonist Substances 0.000 title 1
- MGHPNCMVUAKAIE-UHFFFAOYSA-N diphenylmethanamine Chemical class C=1C=CC=CC=1C(N)C1=CC=CC=C1 MGHPNCMVUAKAIE-UHFFFAOYSA-N 0.000 title 1
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 abstract 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 abstract 2
- RMMXTBMQSGEXHJ-UHFFFAOYSA-N Aminophenazone Chemical compound O=C1C(N(C)C)=C(C)N(C)N1C1=CC=CC=C1 RMMXTBMQSGEXHJ-UHFFFAOYSA-N 0.000 abstract 1
- 241000700199 Cavia porcellus Species 0.000 abstract 1
- 206010011224 Cough Diseases 0.000 abstract 1
- 241000283973 Oryctolagus cuniculus Species 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 229960000212 aminophenazone Drugs 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000003434 antitussive agent Substances 0.000 abstract 1
- 229940124584 antitussives Drugs 0.000 abstract 1
- 229960003920 cocaine Drugs 0.000 abstract 1
- 229960004126 codeine Drugs 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 229940030606 diuretics Drugs 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 abstract 1
- MNQQMTXYJKDJOE-UHFFFAOYSA-N n-benzhydryl-2-piperidin-1-ylacetamide Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)NC(=O)CN1CCCCC1 MNQQMTXYJKDJOE-UHFFFAOYSA-N 0.000 abstract 1
- WVRQZUCIRXSKDM-UHFFFAOYSA-N n-benzhydryl-2-piperidin-1-ylpropanamide Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)NC(=O)C(C)N1CCCCC1 WVRQZUCIRXSKDM-UHFFFAOYSA-N 0.000 abstract 1
- 230000001452 natriuretic effect Effects 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007921 spray Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7017832A FR2088087A1 (en) | 1970-05-15 | 1970-05-15 | Aminoalkanoic acid benzhydrylamides - with analgesic diuretic spasmolytic antitussive activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7017832A FR2088087A1 (en) | 1970-05-15 | 1970-05-15 | Aminoalkanoic acid benzhydrylamides - with analgesic diuretic spasmolytic antitussive activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2088087A1 true FR2088087A1 (en) | 1972-01-07 |
| FR2088087B1 FR2088087B1 (https=) | 1973-04-06 |
Family
ID=9055602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7017832A Granted FR2088087A1 (en) | 1970-05-15 | 1970-05-15 | Aminoalkanoic acid benzhydrylamides - with analgesic diuretic spasmolytic antitussive activity |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2088087A1 (https=) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2520153A (en) * | 1947-09-11 | 1950-08-29 | Sterling Drug Inc | N-(diarylmethyl)-tertiary-aminoalkanamides and their preparation |
-
1970
- 1970-05-15 FR FR7017832A patent/FR2088087A1/fr active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2520153A (en) * | 1947-09-11 | 1950-08-29 | Sterling Drug Inc | N-(diarylmethyl)-tertiary-aminoalkanamides and their preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2088087B1 (https=) | 1973-04-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CL | Concession to grant licenses | ||
| ST | Notification of lapse |