FR2068434A1 - Beta-amino-acrylophenone derivs - Google Patents

Beta-amino-acrylophenone derivs

Info

Publication number
FR2068434A1
FR2068434A1 FR6939610A FR6939610A FR2068434A1 FR 2068434 A1 FR2068434 A1 FR 2068434A1 FR 6939610 A FR6939610 A FR 6939610A FR 6939610 A FR6939610 A FR 6939610A FR 2068434 A1 FR2068434 A1 FR 2068434A1
Authority
FR
France
Prior art keywords
acrylophenone
derivs
beta
amino
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR6939610A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH filed Critical Degussa GmbH
Priority to FR6939610A priority Critical patent/FR2068434A1/en
Priority to ES376359A priority patent/ES376359A1/en
Priority to DE19702037231 priority patent/DE2037231A1/en
Publication of FR2068434A1 publication Critical patent/FR2068434A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Beta-amino-acrylophenone derivs. Title cpds. of formula (I): (where R1 and R2 are H, halogen, lower alkyl, lower alkoxy, OH or NO2; R3 is H or lower alkyl and R4 is H, halogen, lower alkyl, lower alkoxy or OH), which are pharmaceutically active, particularly against cardiac and circulatory disorders and also have anti-inflammatory activity, are prepd. by reacting an R1, R2-substd. alpha-formyl-acetophenone or alkali enolate thereof with an amine H2N-CH(R3)-CHOH-C6H4-R4 (II) or by reacting an R1, R2-substd. propiolophenone with (II). A racemic product may be optically resolved, or a stereochemically uniform product may be obtained by using stereochemically uniform (II) as starting material.
FR6939610A 1969-11-18 1969-11-18 Beta-amino-acrylophenone derivs Withdrawn FR2068434A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR6939610A FR2068434A1 (en) 1969-11-18 1969-11-18 Beta-amino-acrylophenone derivs
ES376359A ES376359A1 (en) 1969-11-18 1970-02-07 Procedure for the preparation of new derivatives of benzoilamidas vinylogas. (Machine-translation by Google Translate, not legally binding)
DE19702037231 DE2037231A1 (en) 1969-11-18 1970-07-28 New vinylogous benzoylamides that are substituted on the stick by a phenyloxyalkyl radical

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6939610A FR2068434A1 (en) 1969-11-18 1969-11-18 Beta-amino-acrylophenone derivs

Publications (1)

Publication Number Publication Date
FR2068434A1 true FR2068434A1 (en) 1971-08-27

Family

ID=9043234

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6939610A Withdrawn FR2068434A1 (en) 1969-11-18 1969-11-18 Beta-amino-acrylophenone derivs

Country Status (3)

Country Link
DE (1) DE2037231A1 (en)
ES (1) ES376359A1 (en)
FR (1) FR2068434A1 (en)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
(LA *REVUE ALLEMANDE:"ARZNEIMITTEL-FOR-SCHUNG VOL.18,NO10 1968 PAGES 1255-1263.) *
LA REVUE ALLEMANDE:"ARZNEIMITTEL-FOR-SCHUNG VOL.18,NO10 1968 PAGES 1255-1263.) *

Also Published As

Publication number Publication date
ES376359A1 (en) 1972-03-16
DE2037231A1 (en) 1971-06-03

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Legal Events

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