FR2013926A1 - Prostaglandins - Google Patents
ProstaglandinsInfo
- Publication number
- FR2013926A1 FR2013926A1 FR6925803A FR6925803A FR2013926A1 FR 2013926 A1 FR2013926 A1 FR 2013926A1 FR 6925803 A FR6925803 A FR 6925803A FR 6925803 A FR6925803 A FR 6925803A FR 2013926 A1 FR2013926 A1 FR 2013926A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- prostaglandines
- prepared
- reacting
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940094443 oxytocics prostaglandins Drugs 0.000 title 1
- 150000003180 prostaglandins Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003259 prostaglandin group Chemical group 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 102220090095 rs1042713 Human genes 0.000 abstract 1
- 102220058910 rs786201402 Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P31/00—Preparation of compounds containing a five-membered ring having two side-chains in ortho position to each other, and having at least one oxygen atom directly bound to the ring in ortho position to one of the side-chains, one side-chain containing, not directly bound to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having at least one oxygen atom bound in gamma-position to the ring, e.g. prostaglandins
Abstract
Prostaglandines E1, F1, A1 and analogues, such as:- are prepared by reacting a disulfonic acid ester of formula:- with water at 0 - 60 degrees C. Prostaglandines of series A are prepared by reacting disulfonic acid ester at 40 - 100 degrees with combination of water, base, the aq. solution of which has pH 8-12, and sufficient water soluble inert organic diluent to provide homogenous reaction mixture. Prostaglandines of series F are prepared by reacting compounds of formula:- with reducing agent for carbonyl groups (in the formulae m=1-6; p=0-7; R15=C 1-4 alkyl or -CH2CCl3; Z=ethyl subst. by fluorine or methyl, ethyl or alkyl; is approx. = bond of group to ring in alpha- or beta-configuration; R6=C1-5 alkyl, R16=H or C1-4 alkyl.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74816768A | 1968-07-29 | 1968-07-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2013926A1 true FR2013926A1 (en) | 1970-04-10 |
| FR2013926B1 FR2013926B1 (en) | 1973-01-12 |
Family
ID=25008303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR6925803A Granted FR2013926A1 (en) | 1968-07-29 | 1969-07-28 | Prostaglandins |
Country Status (10)
| Country | Link |
|---|---|
| BE (1) | BE736727A (en) |
| BR (1) | BR6911098D0 (en) |
| CH (1) | CH548971A (en) |
| DE (1) | DE1937921A1 (en) |
| ES (2) | ES369991A1 (en) |
| FR (1) | FR2013926A1 (en) |
| IL (1) | IL32518A (en) |
| NL (1) | NL6911477A (en) |
| PL (1) | PL80229B1 (en) |
| SE (1) | SE377566B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1204626A1 (en) * | 1999-04-01 | 2002-05-15 | Esperion Therapeutics Inc. | Ether compounds, compositions, and uses thereof |
| EP1849760A1 (en) * | 1999-04-01 | 2007-10-31 | Esperion Therapeutics Inc. | Ether compounds, compositions, and uses thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA944358A (en) * | 1970-11-27 | 1974-03-26 | Upjohn Company (The) | Bicyclic acetals and preparation thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1533808A (en) * | 1966-08-09 | 1968-07-19 | New compounds similar to prostaglandin e1 and prostaglandin f1 and their manufacturing process |
-
1969
- 1969-07-01 IL IL32518A patent/IL32518A/en unknown
- 1969-07-25 SE SE6910520A patent/SE377566B/xx unknown
- 1969-07-25 NL NL6911477A patent/NL6911477A/xx unknown
- 1969-07-25 DE DE19691937921 patent/DE1937921A1/en active Pending
- 1969-07-28 FR FR6925803A patent/FR2013926A1/en active Granted
- 1969-07-28 CH CH1149569A patent/CH548971A/en not_active IP Right Cessation
- 1969-07-28 BR BR211098/69A patent/BR6911098D0/en unknown
- 1969-07-28 PL PL1969135097A patent/PL80229B1/en unknown
- 1969-07-29 ES ES369991A patent/ES369991A1/en not_active Expired
- 1969-07-29 BE BE736727A patent/BE736727A/en unknown
-
1971
- 1971-08-31 ES ES394673A patent/ES394673A1/en not_active Expired
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1533808A (en) * | 1966-08-09 | 1968-07-19 | New compounds similar to prostaglandin e1 and prostaglandin f1 and their manufacturing process |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1204626A1 (en) * | 1999-04-01 | 2002-05-15 | Esperion Therapeutics Inc. | Ether compounds, compositions, and uses thereof |
| EP1204626A4 (en) * | 1999-04-01 | 2003-05-07 | Esperion Therapeutics Inc | Ether compounds, compositions, and uses thereof |
| US7192940B2 (en) | 1999-04-01 | 2007-03-20 | Esperion Therapeutics, Inc. | Ether compounds |
| EP1849760A1 (en) * | 1999-04-01 | 2007-10-31 | Esperion Therapeutics Inc. | Ether compounds, compositions, and uses thereof |
| EP1862444A2 (en) * | 1999-04-01 | 2007-12-05 | Esperion Therapeutics, Inc. | Ether compounds, compositions, and uses thereof |
| EP1862444A3 (en) * | 1999-04-01 | 2008-01-09 | Esperion Therapeutics, Inc. | Ether compounds, compositions, and uses thereof |
| US7709515B2 (en) | 1999-04-01 | 2010-05-04 | Esperion Therapeutics, Inc. | Compositions comprising ether compounds and pharmaceutical uses therefor |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2013926B1 (en) | 1973-01-12 |
| NL6911477A (en) | 1970-02-02 |
| IL32518A (en) | 1974-03-14 |
| BE736727A (en) | 1970-01-29 |
| CH548971A (en) | 1974-05-15 |
| BR6911098D0 (en) | 1973-05-31 |
| DE1937921A1 (en) | 1970-01-29 |
| ES369991A1 (en) | 1972-01-01 |
| ES394673A1 (en) | 1974-02-16 |
| SE377566B (en) | 1975-07-14 |
| PL80229B1 (en) | 1975-08-30 |
| IL32518A0 (en) | 1969-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |