FR2012061A1 - Quinazolinone derivs - with antiphlogistic props - Google Patents

Quinazolinone derivs - with antiphlogistic props

Info

Publication number
FR2012061A1
FR2012061A1 FR6921994A FR6921994A FR2012061A1 FR 2012061 A1 FR2012061 A1 FR 2012061A1 FR 6921994 A FR6921994 A FR 6921994A FR 6921994 A FR6921994 A FR 6921994A FR 2012061 A1 FR2012061 A1 FR 2012061A1
Authority
FR
France
Prior art keywords
degrees
alkyl
inert solvent
derivs
quinazolinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR6921994A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Priority to FR6921994A priority Critical patent/FR2012061A1/en
Publication of FR2012061A1 publication Critical patent/FR2012061A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C07D239/82—Oxygen atoms with an aryl radical attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Quinazolinone derivs with antiphlogistic properties.. G3A. are of formula (I): (where R = H, F, Cl, Br, alkyl with 1 to 5C, alkoxy or alkylthio with 1 to 4C, NO2, CN or CF3; n = 1 or 2, and in the latter case, the two R's may be same or different; R1 = alkyl with 1 to 5C, allyl or propargyl; and R2 = phenyl opt. substd. with one or two F, Cl, Br, alkyl, or alkoxy gps. or by one CF3 group) and are prepared (a) from appropriate aminobenzophenoneimines, (esp. 2-isopropyl-amino-4-methylbenzophenonimine, II), provided that R1 is not tert-alkyl, by cyclisation with methyl or pref. ethyl chlorocarbonate at 60-100 degrees C in the presence of an inert solvent and a base; or with lower alkyl carbamates, particularly excess urethane, and a Lewis acid at 160-80 degrees; or with 1,1'-carbonyldiimidazole in an inert solvent at 60-90 degrees; or with phosgene in the presence of a base and an inert solvent at 10-30 degrees; or (b) corresp. 3,4-dihydroquinazolinones are oxidised with MnO2 or MnO4 at 15-30 degrees, or the analogous thiones are hydrolysed with aqueous alkali at 80-120 degrees; or 3,4-dihydroquinazoline-2-thiones are treated with MnO4 at 0-60 degrees. The products (I) have valuable pharmacological properties, and can be used orally or parenterally in pharmaceutical preparations to reduce inflammation; cpds. such as (II) are also excellent analgetics.
FR6921994A 1969-06-30 1969-06-30 Quinazolinone derivs - with antiphlogistic props Withdrawn FR2012061A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR6921994A FR2012061A1 (en) 1969-06-30 1969-06-30 Quinazolinone derivs - with antiphlogistic props

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6921994A FR2012061A1 (en) 1969-06-30 1969-06-30 Quinazolinone derivs - with antiphlogistic props

Publications (1)

Publication Number Publication Date
FR2012061A1 true FR2012061A1 (en) 1970-03-13

Family

ID=9036620

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6921994A Withdrawn FR2012061A1 (en) 1969-06-30 1969-06-30 Quinazolinone derivs - with antiphlogistic props

Country Status (1)

Country Link
FR (1) FR2012061A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2081322A1 (en) * 1969-12-01 1971-12-03 Sandoz Sa

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE681639C (en) * 1937-05-26 1939-09-27 I G Farbenindustrie Akt Ges Process for the preparation of o-aminobenzonitrile
FR1497456A (en) * 1964-06-15 1967-10-13 Clin Byla Ets Ortho-amino aryl ketimines, heterocyclic compounds attached to them and preparation of these various bodies
FR1503346A (en) * 1965-12-09 1967-11-24 Hoffmann La Roche Process for the preparation of benzophenone derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE681639C (en) * 1937-05-26 1939-09-27 I G Farbenindustrie Akt Ges Process for the preparation of o-aminobenzonitrile
FR1497456A (en) * 1964-06-15 1967-10-13 Clin Byla Ets Ortho-amino aryl ketimines, heterocyclic compounds attached to them and preparation of these various bodies
FR1503346A (en) * 1965-12-09 1967-11-24 Hoffmann La Roche Process for the preparation of benzophenone derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2081322A1 (en) * 1969-12-01 1971-12-03 Sandoz Sa

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Legal Events

Date Code Title Description
ST Notification of lapse