FR2012061A1 - Quinazolinone derivs - with antiphlogistic props - Google Patents
Quinazolinone derivs - with antiphlogistic propsInfo
- Publication number
- FR2012061A1 FR2012061A1 FR6921994A FR6921994A FR2012061A1 FR 2012061 A1 FR2012061 A1 FR 2012061A1 FR 6921994 A FR6921994 A FR 6921994A FR 6921994 A FR6921994 A FR 6921994A FR 2012061 A1 FR2012061 A1 FR 2012061A1
- Authority
- FR
- France
- Prior art keywords
- degrees
- alkyl
- inert solvent
- derivs
- quinazolinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C07D239/82—Oxygen atoms with an aryl radical attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Quinazolinone derivs with antiphlogistic properties.. G3A. are of formula (I): (where R = H, F, Cl, Br, alkyl with 1 to 5C, alkoxy or alkylthio with 1 to 4C, NO2, CN or CF3; n = 1 or 2, and in the latter case, the two R's may be same or different; R1 = alkyl with 1 to 5C, allyl or propargyl; and R2 = phenyl opt. substd. with one or two F, Cl, Br, alkyl, or alkoxy gps. or by one CF3 group) and are prepared (a) from appropriate aminobenzophenoneimines, (esp. 2-isopropyl-amino-4-methylbenzophenonimine, II), provided that R1 is not tert-alkyl, by cyclisation with methyl or pref. ethyl chlorocarbonate at 60-100 degrees C in the presence of an inert solvent and a base; or with lower alkyl carbamates, particularly excess urethane, and a Lewis acid at 160-80 degrees; or with 1,1'-carbonyldiimidazole in an inert solvent at 60-90 degrees; or with phosgene in the presence of a base and an inert solvent at 10-30 degrees; or (b) corresp. 3,4-dihydroquinazolinones are oxidised with MnO2 or MnO4 at 15-30 degrees, or the analogous thiones are hydrolysed with aqueous alkali at 80-120 degrees; or 3,4-dihydroquinazoline-2-thiones are treated with MnO4 at 0-60 degrees. The products (I) have valuable pharmacological properties, and can be used orally or parenterally in pharmaceutical preparations to reduce inflammation; cpds. such as (II) are also excellent analgetics.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR6921994A FR2012061A1 (en) | 1969-06-30 | 1969-06-30 | Quinazolinone derivs - with antiphlogistic props |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR6921994A FR2012061A1 (en) | 1969-06-30 | 1969-06-30 | Quinazolinone derivs - with antiphlogistic props |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2012061A1 true FR2012061A1 (en) | 1970-03-13 |
Family
ID=9036620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR6921994A Withdrawn FR2012061A1 (en) | 1969-06-30 | 1969-06-30 | Quinazolinone derivs - with antiphlogistic props |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2012061A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2081322A1 (en) * | 1969-12-01 | 1971-12-03 | Sandoz Sa |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE681639C (en) * | 1937-05-26 | 1939-09-27 | I G Farbenindustrie Akt Ges | Process for the preparation of o-aminobenzonitrile |
FR1497456A (en) * | 1964-06-15 | 1967-10-13 | Clin Byla Ets | Ortho-amino aryl ketimines, heterocyclic compounds attached to them and preparation of these various bodies |
FR1503346A (en) * | 1965-12-09 | 1967-11-24 | Hoffmann La Roche | Process for the preparation of benzophenone derivatives |
-
1969
- 1969-06-30 FR FR6921994A patent/FR2012061A1/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE681639C (en) * | 1937-05-26 | 1939-09-27 | I G Farbenindustrie Akt Ges | Process for the preparation of o-aminobenzonitrile |
FR1497456A (en) * | 1964-06-15 | 1967-10-13 | Clin Byla Ets | Ortho-amino aryl ketimines, heterocyclic compounds attached to them and preparation of these various bodies |
FR1503346A (en) * | 1965-12-09 | 1967-11-24 | Hoffmann La Roche | Process for the preparation of benzophenone derivatives |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2081322A1 (en) * | 1969-12-01 | 1971-12-03 | Sandoz Sa |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |