FR2010921A1 - Cephalosporin-type antibacterials - used as antibacterial agents, some being active orally - Google Patents

Cephalosporin-type antibacterials - used as antibacterial agents, some being active orally

Info

Publication number
FR2010921A1
FR2010921A1 FR6919763A FR6919763A FR2010921A1 FR 2010921 A1 FR2010921 A1 FR 2010921A1 FR 6919763 A FR6919763 A FR 6919763A FR 6919763 A FR6919763 A FR 6919763A FR 2010921 A1 FR2010921 A1 FR 2010921A1
Authority
FR
France
Prior art keywords
cephalosporin
antibacterial agents
formula
active orally
derivs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR6919763A
Other languages
French (fr)
Other versions
FR2010921B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB2853169A external-priority patent/GB1293375A/en
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Publication of FR2010921A1 publication Critical patent/FR2010921A1/en
Application granted granted Critical
Publication of FR2010921B1 publication Critical patent/FR2010921B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01G—WEIGHING
    • G01G21/00—Details of weighing apparatus
    • G01G21/02—Arrangements of bearings
    • G01G21/04—Arrangements of bearings of knife-edge bearings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

(A) Cephalosporin derivs. of formula (I), their non-toxic derivs. and salts and pharmaceutical compns. contng. them Ar=aromatic gp. X'=NH2 substd. NH2 OH, lower alkanoyloxy m=0 or 1 R'=lower alkyl. Esp. where Ar.CHX'.COOH belongs to the D-series and X'=NH2. (B) Cpds. of formula (IV) R2,3=lower alkyl. (C) Intermediates of formula (V). As antibacterial agents; some are active orally. (1) By acylation of (V). (2) From a 7-acylamino-3-(CH2P) cpd. where P=gp. replaceable by S(O)mR', followed if necessary by oxidn. of the S atom.
FR6919763A 1968-06-14 1969-06-13 Cephalosporin-type antibacterials - used as antibacterial agents, some being active orally Granted FR2010921A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2852768 1968-06-14
GB2853169A GB1293375A (en) 1969-06-05 1969-06-05 Improvements in or relating to fluid control valves

Publications (2)

Publication Number Publication Date
FR2010921A1 true FR2010921A1 (en) 1970-02-20
FR2010921B1 FR2010921B1 (en) 1973-06-08

Family

ID=26259422

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6919763A Granted FR2010921A1 (en) 1968-06-14 1969-06-13 Cephalosporin-type antibacterials - used as antibacterial agents, some being active orally

Country Status (7)

Country Link
BE (1) BE734532A (en)
CH (1) CH550202A (en)
DE (1) DE1930204A1 (en)
DK (1) DK128745B (en)
FR (1) FR2010921A1 (en)
NL (1) NL140413B (en)
SE (1) SE380270B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2106501A1 (en) * 1970-09-14 1972-05-05 Bristol Myers Co
FR2128396A2 (en) * 1971-03-01 1972-10-20 Glaxo Lab Ltd

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2106501A1 (en) * 1970-09-14 1972-05-05 Bristol Myers Co
FR2128396A2 (en) * 1971-03-01 1972-10-20 Glaxo Lab Ltd

Also Published As

Publication number Publication date
NL6909099A (en) 1969-12-16
BE734532A (en) 1969-12-15
FR2010921B1 (en) 1973-06-08
SE380270B (en) 1975-11-03
DK128745B (en) 1974-06-24
DE1930204A1 (en) 1970-01-22
NL140413B (en) 1973-12-17
CH550202A (en) 1974-06-14

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Legal Events

Date Code Title Description
ST Notification of lapse