FR06C0021I2 - Complexes a base de ligands d'acide nucleique de facteur de croissance endothelial vasculaire - Google Patents
Complexes a base de ligands d'acide nucleique de facteur de croissance endothelial vasculaireInfo
- Publication number
- FR06C0021I2 FR06C0021I2 FR06C0021C FR06C0021C FR06C0021I2 FR 06C0021 I2 FR06C0021 I2 FR 06C0021I2 FR 06C0021 C FR06C0021 C FR 06C0021C FR 06C0021 C FR06C0021 C FR 06C0021C FR 06C0021 I2 FR06C0021 I2 FR 06C0021I2
- Authority
- FR
- France
- Prior art keywords
- nucleic acid
- acid ligand
- growth factor
- vascular endothelial
- endothelial growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/739,109 US5859228A (en) | 1995-05-04 | 1996-10-25 | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
US08/870,930 US6168778B1 (en) | 1990-06-11 | 1997-06-06 | Vascular endothelial growth factor (VEGF) Nucleic Acid Ligand Complexes |
US08/897,351 US6051698A (en) | 1997-06-06 | 1997-07-21 | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
PCT/US1997/018944 WO1998018480A1 (en) | 1996-10-25 | 1997-10-17 | Vascular endothelial growth factor (vegf) nucleic acid ligand complexes |
Publications (2)
Publication Number | Publication Date |
---|---|
FR06C0021I1 FR06C0021I1 (ja) | 2006-10-13 |
FR06C0021I2 true FR06C0021I2 (fr) | 2007-08-03 |
Family
ID=27419245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR06C0021C Active FR06C0021I2 (fr) | 1996-10-25 | 2006-07-03 | Complexes a base de ligands d'acide nucleique de facteur de croissance endothelial vasculaire |
Country Status (18)
Country | Link |
---|---|
EP (2) | EP0957929B1 (ja) |
JP (2) | JP3626503B2 (ja) |
KR (1) | KR100514929B1 (ja) |
AT (1) | ATE318143T1 (ja) |
AU (1) | AU733674B2 (ja) |
CA (1) | CA2269072C (ja) |
DE (3) | DE122006000029I2 (ja) |
DK (1) | DK0957929T3 (ja) |
ES (1) | ES2259188T3 (ja) |
FR (1) | FR06C0021I2 (ja) |
GE (1) | GEP20094799B (ja) |
IL (2) | IL129497A0 (ja) |
LU (1) | LU91252I2 (ja) |
NL (1) | NL300234I2 (ja) |
NZ (1) | NZ334859A (ja) |
PT (1) | PT957929E (ja) |
RU (1) | RU2177950C2 (ja) |
WO (1) | WO1998018480A1 (ja) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
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US6346611B1 (en) * | 1990-06-11 | 2002-02-12 | Gilead Sciences, Inc. | High affinity TGfβ nucleic acid ligands and inhibitors |
US6395888B1 (en) | 1996-02-01 | 2002-05-28 | Gilead Sciences, Inc. | High affinity nucleic acid ligands of complement system proteins |
US6232071B1 (en) * | 1990-06-11 | 2001-05-15 | Gilead Sciences, Inc. | Tenascin-C nucleic acid ligands |
AU782620B2 (en) * | 1991-06-10 | 2005-08-11 | Gilead Sciences, Inc. | High affinity vascular endothelial growth factor (VEGF) receptor nucleic acid ligands and inhibitors |
US6762290B1 (en) * | 1999-07-29 | 2004-07-13 | Gilead Sciences, Inc. | High affinity vascular endothelial growth factor (VEGF) receptor nucleic acid ligands and inhibitors |
BR0012443A (pt) * | 1999-07-14 | 2002-04-02 | Alza Corp | Lipolìmero neutro e composições de lipossoma contendo o mesmo |
EP2322648A1 (en) * | 2000-09-26 | 2011-05-18 | Duke University | RNA aptamers and methods for identifying the same |
US7629456B2 (en) * | 2001-10-26 | 2009-12-08 | Noxxon Pharma Ag | Modified L-nucleic acid |
OA12720A (en) * | 2001-11-09 | 2006-06-27 | Eyetech Pharmaceuticals | Methods for treating ocular neovascular diseases. |
US7767803B2 (en) | 2002-06-18 | 2010-08-03 | Archemix Corp. | Stabilized aptamers to PSMA and their use as prostate cancer therapeutics |
JP2005533862A (ja) | 2002-07-25 | 2005-11-10 | アーケミックス コーポレイション | 調節されたアプタマー治療剤 |
US9303262B2 (en) | 2002-09-17 | 2016-04-05 | Archemix Llc | Methods for identifying aptamer regulators |
US8853376B2 (en) | 2002-11-21 | 2014-10-07 | Archemix Llc | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
US10100316B2 (en) | 2002-11-21 | 2018-10-16 | Archemix Llc | Aptamers comprising CPG motifs |
US8039443B2 (en) | 2002-11-21 | 2011-10-18 | Archemix Corporation | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
WO2004050899A2 (en) | 2002-12-03 | 2004-06-17 | Archemix Corporation | Method for in vitro selection of 2’-substituted nucleic acids |
FR2852606A1 (fr) * | 2003-03-18 | 2004-09-24 | Inst Nat Sante Rech Med | Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie |
EP1620547B1 (en) | 2003-04-21 | 2014-06-18 | Archemix LLC | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
CL2004001996A1 (es) * | 2003-08-08 | 2005-05-06 | Eyetech Pharmaceuticals Inc | Aptameros anti-vegf (factor de crecimiento endotelial vascular) con bloqueo nucleotidico 5'-5' o 3'-3' invertido, composicion que lo contiene, util para trastornos de neovascularizacion. |
US7803931B2 (en) | 2004-02-12 | 2010-09-28 | Archemix Corp. | Aptamer therapeutics useful in the treatment of complement-related disorders |
WO2005079363A2 (en) | 2004-02-12 | 2005-09-01 | Archemix Corporation | Aptamer therapeutics useful in the treatment of complement-related disorders |
BRPI0509911A (pt) * | 2004-04-13 | 2007-09-18 | Osi Eyetech Inc | método para inibir a atividade de um sìtio separado de um sìtio de ligação de aptámero em um ligando, métodos para aumentar a faixa antagonista, de receptor de um aptámero de ligação de ligando, do ligando de um aptámero de ligação de receptor, de receptor de um aptámero de vegf, e do ligando de um aptámero de vegfr, método para aumentar uma propriedade antagonista de um aptámero que alveja uma proteìna que interage com uma segunda proteìna, método para identificar um conjugado de aptámero, composto, métodos para liberar uma molécula biologicamente ativa, ácido nucléico, um aptámero, e um aptámero anti-vegf a um olho, composto, composição para liberar uma molécula biologicamente ativa a um olho |
US7579450B2 (en) | 2004-04-26 | 2009-08-25 | Archemix Corp. | Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics |
EP1807107B1 (en) | 2004-11-02 | 2011-09-07 | Archemix Corp. | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
US8101385B2 (en) | 2005-06-30 | 2012-01-24 | Archemix Corp. | Materials and methods for the generation of transcripts comprising modified nucleotides |
AU2006265896B2 (en) | 2005-06-30 | 2012-05-31 | Archemix Corp. | Materials and methods for the generation of fully 2'-modified nucleic acid transcripts |
JP2009510182A (ja) * | 2005-07-28 | 2009-03-12 | (オーエスアイ)アイテツク・インコーポレーテツド | シクリトールリンカーポリマー抱合体 |
WO2007024707A2 (en) | 2005-08-22 | 2007-03-01 | The Regents Of The University Of California | Tlr agonists |
KR100877824B1 (ko) | 2005-11-11 | 2009-01-12 | 한국생명공학연구원 | E2epf ucp-vhl 상호작용 및 그 용도 |
CA2632417A1 (en) * | 2005-12-06 | 2007-06-14 | Domantis Limited | Ligands that have binding specificity for egfr and/or vegf and methods of use therefor |
EP1968643A2 (en) * | 2005-12-16 | 2008-09-17 | Diatos | Cell penetrating peptide conjugates for delivering of nucleic acids into a cell |
EP1970078A4 (en) * | 2006-01-11 | 2010-11-17 | Kyowa Hakko Kirin Co Ltd | COMPOSITION FOR INHIBITING A TARGET GENE IN AN EYEBORN AND REMEDY FOR ACAPIC DISEASE |
JP5406534B2 (ja) | 2006-03-08 | 2014-02-05 | アーケミックス エルエルシー | 補体結合アプタマーおよび眼障害の処置において有用な抗c5剤 |
PT2510946E (pt) | 2007-02-07 | 2015-11-23 | Univ California | Conjugados de agonistas sintéticos de tlr e suas utilizações |
WO2009137095A2 (en) | 2008-05-08 | 2009-11-12 | The Johns Hopkins University | Compositions and methods for modulating an immune response |
WO2010065671A2 (en) * | 2008-12-04 | 2010-06-10 | Curna, Inc. | Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf |
CN104922676B (zh) | 2009-03-20 | 2019-03-12 | Clsn实验室股份有限公司 | 聚胺衍生物 |
EP2504436A1 (en) | 2009-11-23 | 2012-10-03 | INSERM - Institut National de la Santé et de la Recherche Médicale | Aptamers directed against the matrix protein-1 of type a influenza viruses and uses thereof |
TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制vegf-a受體交互作用的經修飾結合性蛋白質 |
WO2012040524A1 (en) * | 2010-09-24 | 2012-03-29 | Mallinckrodt Llc | Aptamer conjugates for targeting of therapeutic and/or diagnostic nanocarriers |
WO2013153138A1 (en) | 2012-04-11 | 2013-10-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Matrix metalloproteinase 9 (mmp-9) aptamer and uses thereof |
US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
AU2013340414B2 (en) | 2012-10-23 | 2019-05-02 | Caris Science, Inc. | Aptamers and uses thereof |
CA2895847C (en) | 2012-12-19 | 2019-01-08 | Caris Science, Inc. | Compositions and methods for aptamer screening |
WO2014148638A1 (ja) | 2013-03-22 | 2014-09-25 | 国立大学法人東京大学 | Il-17に対するアプタマー及びその使用 |
SG10201708882TA (en) | 2013-07-12 | 2017-12-28 | Ophthotech Corp | Methods for treating or preventing ophthalmological conditions |
BR112016004153A2 (pt) | 2013-08-28 | 2019-09-17 | Caris Life Sciences Switzerland Holdings Gmbh | "método para caracterizar uma doença ou distúrbio, kit, composição, método para gerar uma biblioteca de entrada, oligonucleotídeo, pluralidade de oligonucleotídeos e método para identificar um aptâmero |
CN114306575A (zh) | 2014-12-11 | 2022-04-12 | 拜耳医药保健有限责任公司 | 具有小的活动性脉络膜新生血管病变的年龄相关性黄斑变性的治疗 |
KR102585112B1 (ko) | 2014-12-29 | 2023-10-10 | 도레이 카부시키가이샤 | 핵산 분자를 안정하게 포함하는 조성물 |
AU2016229076B2 (en) | 2015-03-09 | 2022-01-20 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
AU2016287499B2 (en) | 2015-06-29 | 2022-08-04 | Caris Science, Inc. | Therapeutic oligonucleotides |
AU2016298317B2 (en) | 2015-07-28 | 2021-02-18 | Caris Science, Inc. | Targeted oligonucleotides |
WO2017046140A1 (en) | 2015-09-18 | 2017-03-23 | Bayer Pharma Aktiengesellschaft | Treatment regimens for dr and rvo in dependence of the extent of retinal ischemia |
WO2017161357A1 (en) | 2016-03-18 | 2017-09-21 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
US11697851B2 (en) | 2016-05-24 | 2023-07-11 | The Regents Of The University Of California | Early ovarian cancer detection diagnostic test based on mRNA isoforms |
US11293017B2 (en) | 2016-05-25 | 2022-04-05 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
EP3332812A1 (en) | 2016-12-07 | 2018-06-13 | Rheinische Friedrich-Wilhelms-Universität Bonn | Nucleic acid-based assembly and use of the assembly in cancer therapy |
TW201904610A (zh) | 2017-06-14 | 2019-02-01 | 德商拜耳製藥公司 | 用於治療新生血管型青光眼之非抗體vegf拮抗劑 |
US11931327B2 (en) | 2017-07-04 | 2024-03-19 | Daiichi Sankyo Company, Limited | Drug for retinal degenerative disease associated with photoreceptor degeneration |
WO2019210097A1 (en) * | 2018-04-25 | 2019-10-31 | Vitrisa Therapeutics, Inc. | Aptamers with stability, potency or half-life for enhanced safety and efficacy |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0462145T3 (da) * | 1989-03-07 | 1994-08-08 | Genentech Inc | Covalente konjugater mellem lipid og oligonucleotid |
US5849479A (en) * | 1990-06-11 | 1998-12-15 | Nexstar Pharmaceuticals, Inc. | High-affinity oligonucleotide ligands to vascular endothelial growth factor (VEGF) |
US5459015A (en) * | 1990-06-11 | 1995-10-17 | Nexstar Pharmaceuticals, Inc. | High-affinity RNA ligands of basic fibroblast growth factor |
US5811533A (en) * | 1990-06-11 | 1998-09-22 | Nexstar Pharmaceuticals, Inc. | High-affinity oligonucleotide ligands to vascular endothelial growth factor (VEGF) |
US6168778B1 (en) * | 1990-06-11 | 2001-01-02 | Nexstar Pharmaceuticals, Inc. | Vascular endothelial growth factor (VEGF) Nucleic Acid Ligand Complexes |
-
1997
- 1997-10-17 ES ES97912811T patent/ES2259188T3/es not_active Expired - Lifetime
- 1997-10-17 RU RU99110377/04A patent/RU2177950C2/ru active
- 1997-10-17 DE DE200612000029 patent/DE122006000029I2/de active Active
- 1997-10-17 DE DE1997635292 patent/DE122006000029I1/de active Pending
- 1997-10-17 PT PT97912811T patent/PT957929E/pt unknown
- 1997-10-17 KR KR10-1999-7003488A patent/KR100514929B1/ko not_active IP Right Cessation
- 1997-10-17 IL IL12949797A patent/IL129497A0/xx unknown
- 1997-10-17 DE DE69735292T patent/DE69735292T2/de not_active Expired - Lifetime
- 1997-10-17 JP JP52055398A patent/JP3626503B2/ja not_active Expired - Lifetime
- 1997-10-17 CA CA002269072A patent/CA2269072C/en not_active Expired - Lifetime
- 1997-10-17 NZ NZ334859A patent/NZ334859A/xx not_active IP Right Cessation
- 1997-10-17 EP EP97912811A patent/EP0957929B1/en not_active Expired - Lifetime
- 1997-10-17 AU AU49904/97A patent/AU733674B2/en not_active Expired
- 1997-10-17 GE GEAP199711120A patent/GEP20094799B/en unknown
- 1997-10-17 WO PCT/US1997/018944 patent/WO1998018480A1/en active IP Right Grant
- 1997-10-17 AT AT97912811T patent/ATE318143T1/de active
- 1997-10-17 DK DK97912811T patent/DK0957929T3/da active
- 1997-10-17 EP EP06003279A patent/EP1685842A3/en not_active Withdrawn
-
1999
- 1999-04-19 IL IL129497A patent/IL129497A/en not_active IP Right Cessation
-
2004
- 2004-10-15 JP JP2004301813A patent/JP4160038B2/ja not_active Expired - Lifetime
-
2006
- 2006-06-14 LU LU91252C patent/LU91252I2/fr unknown
- 2006-07-03 FR FR06C0021C patent/FR06C0021I2/fr active Active
- 2006-07-20 NL NL300234C patent/NL300234I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
DE122006000029I2 (de) | 2007-11-08 |
ATE318143T1 (de) | 2006-03-15 |
IL129497A (en) | 2009-06-15 |
DE69735292D1 (de) | 2006-04-27 |
PT957929E (pt) | 2006-06-30 |
FR06C0021I1 (ja) | 2006-10-13 |
AU733674B2 (en) | 2001-05-24 |
CA2269072A1 (en) | 1998-05-07 |
GEP20094799B (en) | 2009-10-26 |
NL300234I1 (nl) | 2006-09-01 |
NL300234I2 (nl) | 2006-10-02 |
IL129497A0 (en) | 2000-02-29 |
JP2005046160A (ja) | 2005-02-24 |
KR20000052697A (ko) | 2000-08-25 |
KR100514929B1 (ko) | 2005-09-15 |
JP3626503B2 (ja) | 2005-03-09 |
EP0957929B1 (en) | 2006-02-22 |
EP0957929A4 (en) | 2003-06-25 |
JP4160038B2 (ja) | 2008-10-01 |
LU91252I2 (fr) | 2006-08-14 |
ES2259188T3 (es) | 2006-09-16 |
RU2177950C2 (ru) | 2002-01-10 |
EP1685842A2 (en) | 2006-08-02 |
DE122006000029I1 (de) | 2006-10-19 |
CA2269072C (en) | 2006-02-14 |
JP2001505191A (ja) | 2001-04-17 |
DE69735292T2 (de) | 2006-10-19 |
EP0957929A1 (en) | 1999-11-24 |
NZ334859A (en) | 2001-02-23 |
EP1685842A3 (en) | 2006-11-29 |
WO1998018480A1 (en) | 1998-05-07 |
DK0957929T3 (da) | 2006-07-03 |
AU4990497A (en) | 1998-05-22 |
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