FI970149L - Tiatsoli- ja tiadiatsoliyhdisteiden käyttö D3-reseptoriligandeina - Google Patents
Tiatsoli- ja tiadiatsoliyhdisteiden käyttö D3-reseptoriligandeina Download PDFInfo
- Publication number
- FI970149L FI970149L FI970149A FI970149A FI970149L FI 970149 L FI970149 L FI 970149L FI 970149 A FI970149 A FI 970149A FI 970149 A FI970149 A FI 970149A FI 970149 L FI970149 L FI 970149L
- Authority
- FI
- Finland
- Prior art keywords
- thiazole
- receptor ligands
- thiadiazole compounds
- thiadiazole
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Lubricants (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4425145A DE4425145A1 (de) | 1994-07-15 | 1994-07-15 | Verwendung von Thiazol- und Thiadiazolverbindungen |
PCT/EP1995/002783 WO1996002249A1 (de) | 1994-07-15 | 1995-07-14 | Verwendung von thiazol- und thiadiazolverbindungen als d3 dopaminrezeptorligand |
Publications (3)
Publication Number | Publication Date |
---|---|
FI970149A7 FI970149A7 (fi) | 1997-01-14 |
FI970149L true FI970149L (fi) | 1997-01-14 |
FI970149A0 FI970149A0 (fi) | 1997-01-14 |
Family
ID=6523324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI970149A FI970149A0 (fi) | 1994-07-15 | 1995-07-14 | Tiatsoli- ja tiadiatsoliyhdisteiden käyttö D3-reseptoriligandeina |
Country Status (21)
Country | Link |
---|---|
US (1) | US5958923A (cs) |
EP (1) | EP0768879B1 (cs) |
JP (1) | JPH10502915A (cs) |
KR (1) | KR100443216B1 (cs) |
CN (1) | CN1152872A (cs) |
AT (1) | ATE234616T1 (cs) |
AU (1) | AU712422B2 (cs) |
BR (1) | BR9508295A (cs) |
CA (1) | CA2195240A1 (cs) |
CZ (1) | CZ292909B6 (cs) |
DE (2) | DE4425145A1 (cs) |
ES (1) | ES2194918T3 (cs) |
FI (1) | FI970149A0 (cs) |
HU (1) | HUT77554A (cs) |
IL (1) | IL114600A (cs) |
MX (1) | MX9700429A (cs) |
NO (1) | NO312154B1 (cs) |
SI (1) | SI9520081B (cs) |
TW (1) | TW414793B (cs) |
WO (1) | WO1996002249A1 (cs) |
ZA (1) | ZA955869B (cs) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19600934A1 (de) | 1996-01-12 | 1997-07-17 | Basf Ag | Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung |
DE19728996A1 (de) | 1997-07-07 | 1999-01-14 | Basf Ag | Triazolverbindungen und deren Verwendung |
PL347237A1 (en) | 1998-10-08 | 2002-03-25 | Smithkline Beecham Plc | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) |
WO2001072306A1 (de) * | 2000-03-27 | 2001-10-04 | Basf Aktiengesellschaft | Verwendung von dopamin-d3-rezeptor-liganden zur behandlung von erkrankungen des zentralen nervensystems |
HUP0103987A3 (en) * | 2001-09-28 | 2004-11-29 | Richter Gedeon Vegyeszet | Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates |
AU2003205747A1 (en) * | 2002-03-06 | 2003-09-16 | Merck Patent Gmbh | Thiazole derivatives and their use d2- and 5-ht1a-receptor ligands |
WO2004024878A2 (en) | 2002-09-14 | 2004-03-25 | Gov't Of The U.S.A. As Represented By The Secretary Of The Department Of Health And Human Services | Structurally rigid dopamine d3 receptor selective ligands and process for making them |
US7320979B2 (en) * | 2003-04-14 | 2008-01-22 | Abbott Gmbh & Co. Kg. | N-[(piperazinyl)hetaryl]arylsulfonamide compounds |
US20040204422A1 (en) * | 2003-04-14 | 2004-10-14 | Abbott Gmbh & Co. Kg. | N-[(Piperazinyl)hetaryl]arylsulfonamide compounds |
DE10358004A1 (de) | 2003-12-11 | 2005-07-14 | Abbott Gmbh & Co. Kg | Ketolactam-Verbindungen und ihre Verwendung |
US20050137186A1 (en) | 2003-12-18 | 2005-06-23 | Abbott Gmbh & Co. Kg. | Tetrahydrobenzazepines and their use |
ES2375963T3 (es) | 2003-12-18 | 2012-03-07 | Abbott Gmbh & Co. Kg | Tetrahidrobenzacepinas y su uso en la modulación del receptor d3 de la dopamina. |
DE102004027358A1 (de) | 2004-06-04 | 2005-12-29 | Abbott Gmbh & Co. Kg | Pyrimidinverbindungen und ihre Verwendung |
DE102004027359A1 (de) * | 2004-06-04 | 2005-12-29 | Abbott Gmbh & Co. Kg | Pyridin-2-onverbindungen und deren Verwendung |
DE602005018366D1 (de) * | 2004-08-09 | 2010-01-28 | Abbott Gmbh & Co Kg | Zur behandlung von auf eine modulation des dopamin-d3-rezeptors ansprechende erkrankungen geeignete 4-piperazinylpyrimidinverbindungen |
GB0512099D0 (en) * | 2005-06-14 | 2005-07-20 | Glaxo Group Ltd | Compounds |
JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
CN101663292A (zh) * | 2007-04-23 | 2010-03-03 | 詹森药业有限公司 | 作为快速解离的多巴胺2受体拮抗剂的4-烷氧基哒嗪衍生物 |
EP2148879B1 (en) | 2007-04-23 | 2012-11-28 | Janssen Pharmaceutica, N.V. | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
CN102171189B (zh) * | 2008-07-31 | 2013-11-20 | 詹森药业有限公司 | 作为快速解离多巴胺2受体拮抗剂的哌嗪-1-基-三氟甲基取代的吡啶 |
JP7015092B2 (ja) | 2016-07-28 | 2022-02-02 | 塩野義製薬株式会社 | ドーパミンd3受容体拮抗作用を有する含窒素縮環化合物 |
JPWO2019146739A1 (ja) | 2018-01-26 | 2021-01-07 | 塩野義製薬株式会社 | ドーパミンd3受容体拮抗作用を有する縮環化合物 |
WO2019146740A1 (ja) | 2018-01-26 | 2019-08-01 | 塩野義製薬株式会社 | ドーパミンd3受容体拮抗作用を有する環式化合物 |
AU2023211068B2 (en) | 2022-01-29 | 2024-12-12 | Suven Life Sciences Limited | Benzoisothiazole and benzoisoxazole compounds for the treatment of mental disorders |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1053085A (cs) * | 1964-03-26 | |||
DE1695410A1 (de) * | 1967-04-20 | 1971-04-08 | Merck Patent Gmbh | Verfahren zur Herstellung von 1-(Thiazolyl-5-alkyl)-4-(pyridyl-2)-piperazinen |
US3522846A (en) * | 1968-10-04 | 1970-08-04 | Robert V New | Method and apparatus for production amplification by spontaneous emission of radiation |
US3717651A (en) * | 1970-04-20 | 1973-02-20 | Shell Oil Co | Thiazoles |
US4074049A (en) * | 1976-11-19 | 1978-02-14 | The Dow Chemical Company | Antithrombotic 1,3,4-thiadiazole |
US4943580A (en) * | 1987-03-09 | 1990-07-24 | Janssen Pharmaceutica N.V. | Anti-histaminic benzimidazole, imidazopyridine and purine derivatives |
NZ223654A (en) * | 1987-03-09 | 1990-03-27 | Janssen Pharmaceutica Nv | 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions |
US4935424A (en) * | 1988-05-27 | 1990-06-19 | Warner-Lambert Company | 4 or 5-(substituted piperazinylalkyl)-2-aminothiazoles as antipsychotic agents |
FR2636628B1 (fr) * | 1988-08-25 | 1990-12-28 | Sanofi Sa | Derives du thiadiazole-1,3,4, leur procede d'obtention et compositions pharmaceutiques en contenant |
DE3923675A1 (de) * | 1989-07-18 | 1991-01-24 | Basf Ag | Amonoalkylsubstituierte 2-aminothiazole und diese enthaltende therapeutische mittel |
US5273977A (en) * | 1990-11-05 | 1993-12-28 | Warner-Lambert Company | Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents |
DE4119756A1 (de) * | 1991-06-15 | 1992-12-17 | Basf Ag | Aminoalkylsubstituierte 5-mercaptothiazole, ihre herstellung und verwendung |
DE4119757A1 (de) * | 1991-06-15 | 1992-12-17 | Basf Ag | Aminoalkylsubstituierte thiazolin-2-one, ihre herstellung und verwendung |
DE4119758A1 (de) * | 1991-06-15 | 1992-12-17 | Basf Ag | Aminoalkylsubstituierte 2-amino-5-mercaptothiadiazole, ihre herstellung und verwendung |
DE4119755A1 (de) * | 1991-06-15 | 1992-12-17 | Basf Ag | Aminoalkylsubstituierte 2-amino-1,3,4-thiadiazole, ihre herstellung und verwendung |
ZA9610046B (en) * | 1995-12-01 | 1997-07-10 | Ciba Geigy | Process for preparing 2-chlorothiazole compounds |
-
1994
- 1994-07-15 DE DE4425145A patent/DE4425145A1/de not_active Withdrawn
-
1995
- 1995-07-14 MX MX9700429A patent/MX9700429A/es not_active IP Right Cessation
- 1995-07-14 CZ CZ199794A patent/CZ292909B6/cs not_active IP Right Cessation
- 1995-07-14 DE DE59510596T patent/DE59510596D1/de not_active Expired - Lifetime
- 1995-07-14 CA CA002195240A patent/CA2195240A1/en not_active Abandoned
- 1995-07-14 CN CN95194140A patent/CN1152872A/zh active Pending
- 1995-07-14 FI FI970149A patent/FI970149A0/fi not_active IP Right Cessation
- 1995-07-14 IL IL11460095A patent/IL114600A/xx not_active IP Right Cessation
- 1995-07-14 SI SI9520081A patent/SI9520081B/sl not_active IP Right Cessation
- 1995-07-14 HU HU9700115A patent/HUT77554A/hu unknown
- 1995-07-14 ZA ZA955869A patent/ZA955869B/xx unknown
- 1995-07-14 AU AU31115/95A patent/AU712422B2/en not_active Ceased
- 1995-07-14 ES ES95926897T patent/ES2194918T3/es not_active Expired - Lifetime
- 1995-07-14 BR BR9508295A patent/BR9508295A/pt not_active Application Discontinuation
- 1995-07-14 EP EP95926897A patent/EP0768879B1/de not_active Expired - Lifetime
- 1995-07-14 KR KR1019970700268A patent/KR100443216B1/ko not_active Expired - Fee Related
- 1995-07-14 AT AT95926897T patent/ATE234616T1/de not_active IP Right Cessation
- 1995-07-14 WO PCT/EP1995/002783 patent/WO1996002249A1/de active IP Right Grant
- 1995-07-14 JP JP8504702A patent/JPH10502915A/ja not_active Ceased
- 1995-07-14 US US08/765,915 patent/US5958923A/en not_active Expired - Lifetime
- 1995-08-08 TW TW084108222A patent/TW414793B/zh not_active IP Right Cessation
-
1997
- 1997-01-14 NO NO19970164A patent/NO312154B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI970149A7 (fi) | 1997-01-14 |
KR970704438A (ko) | 1997-09-06 |
BR9508295A (pt) | 1998-01-13 |
US5958923A (en) | 1999-09-28 |
AU3111595A (en) | 1996-02-16 |
NO970164L (no) | 1997-03-14 |
EP0768879A1 (de) | 1997-04-23 |
EP0768879B1 (de) | 2003-03-19 |
SI9520081B (sl) | 2003-12-31 |
CZ9497A3 (en) | 1997-09-17 |
HU9700115D0 (en) | 1997-02-28 |
NO312154B1 (no) | 2002-04-02 |
WO1996002249A1 (de) | 1996-02-01 |
DE4425145A1 (de) | 1996-01-18 |
ES2194918T3 (es) | 2003-12-01 |
ZA955869B (en) | 1997-01-14 |
AU712422B2 (en) | 1999-11-04 |
CN1152872A (zh) | 1997-06-25 |
DE59510596D1 (de) | 2003-04-24 |
CA2195240A1 (en) | 1996-02-01 |
KR100443216B1 (ko) | 2004-11-20 |
ATE234616T1 (de) | 2003-04-15 |
MX9700429A (es) | 1998-05-31 |
CZ292909B6 (cs) | 2004-01-14 |
HUT77554A (hu) | 1998-05-28 |
FI970149A0 (fi) | 1997-01-14 |
TW414793B (en) | 2000-12-11 |
NO970164D0 (no) | 1997-01-14 |
IL114600A (en) | 1999-11-30 |
JPH10502915A (ja) | 1998-03-17 |
IL114600A0 (en) | 1995-11-27 |
SI9520081A (en) | 1997-08-31 |
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