FI964789A0 - Elastaasin pefluorialkyyliketoni-inhibiittoreita ja menetelmiä niiden valmistamiseksi - Google Patents

Elastaasin pefluorialkyyliketoni-inhibiittoreita ja menetelmiä niiden valmistamiseksi

Info

Publication number
FI964789A0
FI964789A0 FI964789A FI964789A FI964789A0 FI 964789 A0 FI964789 A0 FI 964789A0 FI 964789 A FI964789 A FI 964789A FI 964789 A FI964789 A FI 964789A FI 964789 A0 FI964789 A0 FI 964789A0
Authority
FI
Finland
Prior art keywords
elastase
pct
processes
pefluoroalkyl
inhibitors
Prior art date
Application number
FI964789A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI964789A (fi
Inventor
Jr William Arthur Metz
Timothy Thomas Curran
Joseph Paul Burkhart
Michael Richard Angelastro
Norton Paul Peet
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of FI964789A0 publication Critical patent/FI964789A0/fi
Publication of FI964789A publication Critical patent/FI964789A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI964789A 1994-06-02 1996-11-29 Elastaasin pefluorialkyyliketoni-inhibiittoreita ja menetelmiä niiden valmistamiseksi FI964789A (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25285794A 1994-06-02 1994-06-02
US32752094A 1994-10-20 1994-10-20
PCT/US1995/005363 WO1995033762A1 (en) 1994-06-02 1995-05-01 Perfluoroalkyl ketone inhibitors of elastase and processes for making the same

Publications (2)

Publication Number Publication Date
FI964789A0 true FI964789A0 (fi) 1996-11-29
FI964789A FI964789A (fi) 1996-11-29

Family

ID=26942742

Family Applications (1)

Application Number Title Priority Date Filing Date
FI964789A FI964789A (fi) 1994-06-02 1996-11-29 Elastaasin pefluorialkyyliketoni-inhibiittoreita ja menetelmiä niiden valmistamiseksi

Country Status (19)

Country Link
US (1) US6008196A (hu)
EP (1) EP0763055B1 (hu)
JP (1) JP3721538B2 (hu)
KR (1) KR100366328B1 (hu)
CN (1) CN1152048C (hu)
AT (1) ATE186305T1 (hu)
AU (1) AU690986B2 (hu)
CA (1) CA2189526C (hu)
DE (1) DE69513167T2 (hu)
DK (1) DK0763055T3 (hu)
ES (1) ES2137509T3 (hu)
FI (1) FI964789A (hu)
GR (1) GR3032294T3 (hu)
HU (1) HU221311B1 (hu)
IL (1) IL113941A (hu)
NO (1) NO316706B1 (hu)
NZ (1) NZ284766A (hu)
TW (1) TW376388B (hu)
WO (1) WO1995033762A1 (hu)

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KR100367389B1 (ko) * 1994-06-02 2003-07-18 메렐 파마슈티칼스 인크. 엘라스타제억제제의프로드러그로서아실화에놀유도체
US20020119985A1 (en) 1994-11-21 2002-08-29 Albert Gyorkos Serine protease inhibitors
US6150334A (en) * 1994-11-21 2000-11-21 Cortech, Inc. Serine protease inhibitors-tripeptoid analogs
US6001811A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors--N-substituted derivatives
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
US6159938A (en) * 1994-11-21 2000-12-12 Cortech, Inc. Serine protease inhibitors comprising α-keto heterocycles
US6015791A (en) * 1994-11-21 2000-01-18 Cortech Inc. Serine protease inhibitors-cycloheptane derivatives
US6001813A (en) * 1994-11-21 1999-12-14 Cortech Inc. Val-pro containing α-keto oxadiazoles as serine protease inhibitors
US5998379A (en) * 1994-11-21 1999-12-07 Cortech Inc. Serine protease inhibitors-proline analogs
US6001814A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors
US6100238A (en) * 1994-11-21 2000-08-08 Cortech Inc. Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
TR199901681T2 (xx) * 1996-12-06 2000-03-21 Cortech, Inc. Serin proteas inhibit�rleri.
US6656910B2 (en) 1997-12-04 2003-12-02 Cortech, Inc. Serine protease inhibitors
US6255453B1 (en) 1998-06-03 2001-07-03 Cortech, Inc. Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors
AU3731400A (en) * 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Methods and compositions useful in inhibiting apoptosis
KR101036058B1 (ko) * 2002-04-25 2011-05-19 더 스크립스 리서치 인스티튜트 폐질환 증상의 치료 및 예방
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
PT1531791E (pt) * 2002-06-07 2010-12-16 Dyax Corp Prevenção e redução da isquémia
US20070020252A1 (en) * 2003-08-29 2007-01-25 Ladner Robert C Modified protease inhibitors
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
AU2006332774A1 (en) * 2005-12-29 2007-07-12 Dyax Corp. Protease inhibition
JP2010536870A (ja) * 2007-08-21 2010-12-02 ジェンザイム・コーポレーション カリクレイン阻害剤を用いた治療
CN102307594A (zh) * 2009-01-06 2012-01-04 戴埃克斯有限公司 用激肽释放酶抑制剂治疗粘膜炎
PT3459564T (pt) * 2010-01-06 2022-01-31 Takeda Pharmaceuticals Co Proteínas de ligação à calicreína plasmática
KR102320178B1 (ko) 2011-01-06 2021-11-02 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
IL295414A (en) 2014-03-27 2022-10-01 Takeda Pharmaceuticals Co Compositions and methods for treating macular edema as a result of diabetes
US11286307B2 (en) 2015-12-11 2022-03-29 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
US20220354833A1 (en) 2019-09-17 2022-11-10 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
WO2021209739A1 (en) 2020-04-16 2021-10-21 Mereo Biopharma 4 Limited Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
TW202325294A (zh) 2021-10-20 2023-07-01 英商梅瑞奧生物製藥４有限公司 用於治療纖維化之嗜中性球彈性蛋白酶抑制劑

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US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
DE3324534A1 (de) * 1983-07-07 1985-01-17 Ciba-Geigy Ag, Basel Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
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US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
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KR920701200A (ko) * 1990-03-30 1992-08-11 미즈노 시게루 신규의 4h-3,1-벤조옥사진-4-온 유도체
EP0564561A4 (en) * 1990-12-28 1994-08-10 Georgia Tech Res Inst Peptides ketoamides, ketoacids, and ketoesters
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
EP0573603B1 (en) * 1991-03-01 2003-06-25 Dyax Corp. Inhibitors of human neutrophil elastase and human cathepsin g
ATE181925T1 (de) * 1991-05-23 1999-07-15 Merrell Pharma Inc Hemmstoffe für kathepsin-g und elastase zur verhütung von bindegewebsabbau
AU655831B2 (en) * 1991-08-22 1995-01-12 Merrell Pharmaceuticals Inc. Novel orally-active elastase inhibitors
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
CN1078886C (zh) * 1993-10-01 2002-02-06 默里尔药物公司 抑制β－淀粉样蛋白产生的抑制剂
HU221197B1 (en) * 1994-06-02 2002-08-28 Aventis Pharma Inc Elastase inhibitor tripeptides and pharmaceutical compositions comprising thereof
KR100367389B1 (ko) * 1994-06-02 2003-07-18 메렐 파마슈티칼스 인크. 엘라스타제억제제의프로드러그로서아실화에놀유도체
DK0763055T3 (da) * 1994-06-02 2000-05-08 Merrell Pharma Inc Perflouralkylketon-inhibitorer af elastase og fremgangsmåde til fremstilling deraf

Also Published As

Publication number Publication date
HUT75318A (en) 1997-05-28
DE69513167T2 (de) 2000-06-15
NO965098D0 (no) 1996-11-29
CN1149876A (zh) 1997-05-14
EP0763055B1 (en) 1999-11-03
EP0763055A1 (en) 1997-03-19
NZ284766A (en) 1998-06-26
US6008196A (en) 1999-12-28
IL113941A (en) 2000-02-17
HU9603311D0 (en) 1997-01-28
TW376388B (en) 1999-12-11
JP3721538B2 (ja) 2005-11-30
NO316706B1 (no) 2004-04-13
AU690986B2 (en) 1998-05-07
CA2189526C (en) 2001-02-27
AU2400095A (en) 1996-01-04
ATE186305T1 (de) 1999-11-15
ES2137509T3 (es) 1999-12-16
CN1152048C (zh) 2004-06-02
IL113941A0 (en) 1995-08-31
MX9606031A (es) 1998-05-31
JPH10501529A (ja) 1998-02-10
NO965098L (no) 1997-01-31
DK0763055T3 (da) 2000-05-08
CA2189526A1 (en) 1995-12-14
FI964789A (fi) 1996-11-29
DE69513167D1 (de) 1999-12-09
GR3032294T3 (en) 2000-04-27
HU221311B1 (en) 2002-09-28
KR100366328B1 (ko) 2003-03-06
WO1995033762A1 (en) 1995-12-14

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Legal Events

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MA Patent expired