FI960253A - Stabilization of aerosolized proteins - Google Patents

Stabilization of aerosolized proteins Download PDF

Info

Publication number
FI960253A
FI960253A FI960253A FI960253A FI960253A FI 960253 A FI960253 A FI 960253A FI 960253 A FI960253 A FI 960253A FI 960253 A FI960253 A FI 960253A FI 960253 A FI960253 A FI 960253A
Authority
FI
Finland
Prior art keywords
stabilization
aerosolized
proteins
aerosolized proteins
Prior art date
Application number
FI960253A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI960253A0 (en
Inventor
Tsutomu Arakawa
Ralph W Niven
Steven J Prestrelski
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of FI960253A0 publication Critical patent/FI960253A0/en
Publication of FI960253A publication Critical patent/FI960253A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Anesthesiology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Colloid Chemistry (AREA)
FI960253A 1993-07-19 1996-01-18 Stabilization of aerosolized proteins FI960253A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9384093A 1993-07-19 1993-07-19
PCT/US1994/008136 WO1995003034A1 (en) 1993-07-19 1994-07-19 Stabilization of aerosolized proteins

Publications (2)

Publication Number Publication Date
FI960253A0 FI960253A0 (en) 1996-01-18
FI960253A true FI960253A (en) 1996-03-18

Family

ID=22241106

Family Applications (1)

Application Number Title Priority Date Filing Date
FI960253A FI960253A (en) 1993-07-19 1996-01-18 Stabilization of aerosolized proteins

Country Status (8)

Country Link
EP (1) EP0710102A1 (en)
JP (1) JPH09501418A (en)
AU (1) AU691514B2 (en)
CA (1) CA2167538A1 (en)
FI (1) FI960253A (en)
NO (1) NO960217L (en)
NZ (1) NZ271181A (en)
WO (1) WO1995003034A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030113271A1 (en) * 1997-01-29 2003-06-19 University Technology Corporation Formulations for pulmonary delivery
DE19733651A1 (en) * 1997-08-04 1999-02-18 Boehringer Ingelheim Pharma Aqueous aerosol preparations containing biologically active marrow molecules and processes for producing corresponding aerosols
EP1244432A2 (en) * 1999-12-30 2002-10-02 Chiron Corporation Methods for pulmonary delivery of interleukin-2
EP1129720B1 (en) 2000-02-29 2004-06-23 Pfizer Products Inc. Stabilized granulocyte colony stimulating factor
MXPA03006952A (en) 2001-02-02 2004-10-15 Johnson & Johnson Treatment of neurological dysfunction comprising fructopyranose sulfamates and erythropoietin.
US20030072717A1 (en) 2001-02-23 2003-04-17 Vapotronics, Inc. Inhalation device having an optimized air flow path
US20030064052A1 (en) * 2001-05-21 2003-04-03 Ponwell Enterprises, Ltd. Compositions for protein delivery via the pulmonary route
JP2004087560A (en) 2002-08-23 2004-03-18 Sansha Electric Mfg Co Ltd Power supply apparatus
KR20100098697A (en) * 2007-12-13 2010-09-08 글락소 그룹 리미티드 Compositions for pulmonary delivery
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
JP5670421B2 (en) 2009-03-31 2015-02-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Component surface coating method
EP2432531B1 (en) 2009-05-18 2019-03-06 Boehringer Ingelheim International GmbH Adapter, inhalation device and nebulizer
CA2781792C (en) 2009-11-25 2019-04-02 Boehringer Ingelheim International Gmbh Nebulizer
WO2011064163A1 (en) 2009-11-25 2011-06-03 Boehringer Ingelheim International Gmbh Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
WO2011160932A1 (en) 2010-06-24 2011-12-29 Boehringer Ingelheim International Gmbh Nebulizer
EP2694220B1 (en) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Medical device comprising a container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
PL2739314T3 (en) 2011-08-02 2019-09-30 Alfasigma S.P.A. Pharmaceutical composition of oxidised avidin suitable for inhalation
WO2013152894A1 (en) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Atomiser with coding means
EP3030298B1 (en) 2013-08-09 2017-10-11 Boehringer Ingelheim International GmbH Nebulizer
PL2835146T3 (en) 2013-08-09 2021-04-06 Boehringer Ingelheim International Gmbh Nebulizer
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
ES2913297T3 (en) 2014-05-07 2022-06-01 Boehringer Ingelheim Int nebulizer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897256A (en) * 1986-11-25 1990-01-30 Abbott Laboratories LHRH analog formulations
GB8921222D0 (en) * 1989-09-20 1989-11-08 Riker Laboratories Inc Medicinal aerosol formulations
RU2054180C1 (en) * 1991-08-21 1996-02-10 Жирнов Олег Петрович (н/п) Method and aerosol for treating respiratory virus infections

Also Published As

Publication number Publication date
NO960217D0 (en) 1996-01-18
NO960217L (en) 1996-03-18
EP0710102A1 (en) 1996-05-08
NZ271181A (en) 1998-06-26
FI960253A0 (en) 1996-01-18
WO1995003034A1 (en) 1995-02-02
JPH09501418A (en) 1997-02-10
AU691514B2 (en) 1998-05-21
CA2167538A1 (en) 1995-02-02
AU7473294A (en) 1995-02-20

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