NO960217L - Stabilization of aerosolized proteins - Google Patents

Stabilization of aerosolized proteins

Info

Publication number
NO960217L
NO960217L NO960217A NO960217A NO960217L NO 960217 L NO960217 L NO 960217L NO 960217 A NO960217 A NO 960217A NO 960217 A NO960217 A NO 960217A NO 960217 L NO960217 L NO 960217L
Authority
NO
Norway
Prior art keywords
stabilized
proteins
aerosolization
surfactant
stabilization
Prior art date
Application number
NO960217A
Other languages
Norwegian (no)
Other versions
NO960217D0 (en
Inventor
Tsutomu Arakawa
Ralph W Niven
Steven J Prestrelski
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of NO960217D0 publication Critical patent/NO960217D0/en
Publication of NO960217L publication Critical patent/NO960217L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Anesthesiology (AREA)
  • Toxicology (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Colloid Chemistry (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer en fremgangsmåte for beskyttelse av proteiner mot aerosoliserings- indusert nedbrytning og tap av proteinaktivitet. De aerosoliserte proteiner stabiliseres ved å tilsette en vannoppløselig, polar, organisk forbindelse, slik som polyetylenglykol, eller et overflateaktivt middel til den vandige oppløsning før aerosolisering. Forelig- gende oppfinnelse tilveiebringer videre en stabilisert vandig proteinoppløsning som inneholder en polar, organisk for- bindelse eller et overflateaktivt middel, og et system for aerosolisering av den stabiliserte vandige, proteinholdige oppløsning.The present invention provides a method for protecting proteins against aerosolization-induced degradation and loss of protein activity. The aerosolized proteins are stabilized by adding a water-soluble polar organic compound, such as polyethylene glycol, or a surfactant to the aqueous solution prior to aerosolization. The present invention further provides a stabilized aqueous protein solution containing a polar, organic compound or surfactant, and a system for aerosolizing the stabilized aqueous proteinaceous solution.

NO960217A 1993-07-19 1996-01-18 Stabilization of aerosolized proteins NO960217L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9384093A 1993-07-19 1993-07-19
PCT/US1994/008136 WO1995003034A1 (en) 1993-07-19 1994-07-19 Stabilization of aerosolized proteins

Publications (2)

Publication Number Publication Date
NO960217D0 NO960217D0 (en) 1996-01-18
NO960217L true NO960217L (en) 1996-03-18

Family

ID=22241106

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960217A NO960217L (en) 1993-07-19 1996-01-18 Stabilization of aerosolized proteins

Country Status (8)

Country Link
EP (1) EP0710102A1 (en)
JP (1) JPH09501418A (en)
AU (1) AU691514B2 (en)
CA (1) CA2167538A1 (en)
FI (1) FI960253L (en)
NO (1) NO960217L (en)
NZ (1) NZ271181A (en)
WO (1) WO1995003034A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030113271A1 (en) * 1997-01-29 2003-06-19 University Technology Corporation Formulations for pulmonary delivery
DE19733651A1 (en) * 1997-08-04 1999-02-18 Boehringer Ingelheim Pharma Aqueous aerosol preparations containing biologically active marrow molecules and processes for producing corresponding aerosols
JP2003519175A (en) * 1999-12-30 2003-06-17 カイロン コーポレイション Methods for pulmonary delivery of interleukin-2
JP3544180B2 (en) 2000-02-29 2004-07-21 ファイザー・プロダクツ・インク Stabilized granulocyte colony stimulating factor
WO2002064085A2 (en) 2001-02-02 2002-08-22 Ortho-Mcneil Pharmaceutical, Inc. Treatment of neurological dysfunction comprising fructopyranose sulfamates and erythropoietin
US20030072717A1 (en) 2001-02-23 2003-04-17 Vapotronics, Inc. Inhalation device having an optimized air flow path
EP1389137B1 (en) * 2001-05-21 2006-07-19 InJet Digital Aerosols Limited Compositions for protein delivery via the pulmonary route
JP2004087560A (en) 2002-08-23 2004-03-18 Sansha Electric Mfg Co Ltd Power supply
US20100260853A1 (en) * 2007-12-13 2010-10-14 Amrik Basran Compositions for pulmonary delivery
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
EP2414560B1 (en) 2009-03-31 2013-10-23 Boehringer Ingelheim International GmbH Method for coating a surface of a component
US9265910B2 (en) 2009-05-18 2016-02-23 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and nebulizer
EP2504051B1 (en) 2009-11-25 2019-09-04 Boehringer Ingelheim International GmbH Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
CA2781792C (en) 2009-11-25 2019-04-02 Boehringer Ingelheim International Gmbh Nebulizer
EP2585151B1 (en) 2010-06-24 2018-04-04 Boehringer Ingelheim International GmbH Nebulizer
EP2694220B1 (en) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Medical device comprising a container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
EP2739314B1 (en) 2011-08-02 2019-05-22 Alfasigma S.p.A. Pharmaceutical composition of oxidised avidin suitable for inhalation
WO2013152894A1 (en) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Atomiser with coding means
JP6643231B2 (en) 2013-08-09 2020-02-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Nebulizer
ES2836977T3 (en) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizer
BR112016023983B1 (en) 2014-05-07 2022-10-18 Boehringer Ingelheim International Gmbh CONTAINER FOR A NEBULIZER, NEBULIZER FOR A FLUID AND METHOD FOR CONNECTING A CONTAINER TO AN INDICATOR DEVICE
SG11201608891RA (en) 2014-05-07 2016-11-29 Boehringer Ingelheim Int Nebulizer, indicator device and container
WO2015169430A1 (en) 2014-05-07 2015-11-12 Boehringer Ingelheim International Gmbh Nebulizer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897256A (en) * 1986-11-25 1990-01-30 Abbott Laboratories LHRH analog formulations
GB8921222D0 (en) * 1989-09-20 1989-11-08 Riker Laboratories Inc Medicinal aerosol formulations
RU2054180C1 (en) * 1991-08-21 1996-02-10 Жирнов Олег Петрович (н/п) Method and aerosol for treating respiratory virus infections

Also Published As

Publication number Publication date
NO960217D0 (en) 1996-01-18
JPH09501418A (en) 1997-02-10
WO1995003034A1 (en) 1995-02-02
AU691514B2 (en) 1998-05-21
CA2167538A1 (en) 1995-02-02
NZ271181A (en) 1998-06-26
FI960253A7 (en) 1996-03-18
AU7473294A (en) 1995-02-20
FI960253L (en) 1996-03-18
EP0710102A1 (en) 1996-05-08
FI960253A0 (en) 1996-01-18

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