FI951541A0 - Desulfatohirudin med hög molekylvikt - Google Patents

Desulfatohirudin med hög molekylvikt

Info

Publication number
FI951541A0
FI951541A0 FI951541A FI951541A FI951541A0 FI 951541 A0 FI951541 A0 FI 951541A0 FI 951541 A FI951541 A FI 951541A FI 951541 A FI951541 A FI 951541A FI 951541 A0 FI951541 A0 FI 951541A0
Authority
FI
Finland
Prior art keywords
desulphatohirudin
molecular weight
high molecular
weight
weight desulphatohirudin
Prior art date
Application number
FI951541A
Other languages
English (en)
Finnish (fi)
Other versions
FI951541A (sv
Inventor
Hugo Grossenbacher
Jui Yoa Chang
Walter Maerki
Original Assignee
Ciba Geigy Ag
Upc Gen Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag, Upc Gen Pharma Ag filed Critical Ciba Geigy Ag
Publication of FI951541A publication Critical patent/FI951541A/sv
Publication of FI951541A0 publication Critical patent/FI951541A0/sv

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/815Protease inhibitors from leeches, e.g. hirudin, eglin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans
    • A61K38/58Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
FI951541A 1993-08-04 1995-03-31 Desulfatohirudin med hög molekylvikt FI951541A0 (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93810552 1993-08-04
PCT/EP1994/002438 WO1995004823A1 (en) 1993-08-04 1994-07-23 High molecular weight desulphatohirudin

Publications (2)

Publication Number Publication Date
FI951541A FI951541A (sv) 1995-03-31
FI951541A0 true FI951541A0 (sv) 1995-03-31

Family

ID=8215008

Family Applications (1)

Application Number Title Priority Date Filing Date
FI951541A FI951541A0 (sv) 1993-08-04 1995-03-31 Desulfatohirudin med hög molekylvikt

Country Status (15)

Country Link
US (1) US5661001A (sv)
EP (1) EP0663009A1 (sv)
JP (1) JPH08502661A (sv)
KR (1) KR950703645A (sv)
CN (1) CN1113389A (sv)
AU (1) AU685835B2 (sv)
CA (1) CA2144523A1 (sv)
FI (1) FI951541A0 (sv)
HU (1) HUT72926A (sv)
IL (1) IL110540A0 (sv)
NO (1) NO951277L (sv)
NZ (1) NZ271088A (sv)
SG (1) SG49862A1 (sv)
WO (1) WO1995004823A1 (sv)
ZA (1) ZA945775B (sv)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2438094C (en) * 2001-02-23 2011-10-11 Immunex Corporation Increased recovery of active proteins
CN1328380C (zh) * 2001-09-24 2007-07-25 天津天士力制药股份有限公司 高效表达水蛭素及其生产方法
CA2613691A1 (en) 2005-07-05 2007-01-11 Baker Medical Research Institute Anticoagulation agent and uses thereof
US7803762B1 (en) 2009-08-20 2010-09-28 The Medicines Company Ready-to-use bivalirudin compositions
CN101993489B (zh) * 2009-08-20 2013-10-23 重庆富进生物医药有限公司 可逆转水蛭素
US7985733B1 (en) 2010-01-06 2011-07-26 The Medicines Company Buffer-based method for preparing bivalirudin drug product
CN117683081A (zh) * 2021-09-24 2024-03-12 江西康之康中药科技有限公司 一种降血压肽及其在降血压制品上的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4620948A (en) * 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
DE3479520D1 (en) * 1983-11-21 1989-09-28 Ciba Geigy Ag Synthesis of tissue plasminogen activator(tpa) by yeast
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
GB8508340D0 (en) * 1985-03-29 1985-05-09 Creighton T E Production of protein
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
IL86090A (en) * 1987-04-16 1993-03-15 Cetus Oncology Corp Production of purified, biologically active, bacterially produced recombinant human csf-1
ATE156491T1 (de) * 1987-05-11 1997-08-15 Chiron Corp Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
CA1340646C (en) * 1987-05-21 1999-07-13 John L. Krstenansky Cyclic anticoagulant peptides
GB8809860D0 (en) * 1988-04-26 1988-06-02 Ciba Geigy Ag Process for production of polypeptides
AU614121B2 (en) * 1988-05-04 1991-08-22 Novartis Ag Improvements in the production of polypeptides
ES2052062T3 (es) * 1988-06-11 1994-07-01 Ciba Geigy Ag Nuevos polipeptidos con actividad anticoagulante.
US5112615A (en) * 1988-08-03 1992-05-12 New England Deaconess Hospital Corporation Soluble hirudin conjugates
DE59010205D1 (de) * 1989-12-01 1996-04-18 Basf Ag Hirudin-Muteine und deren Polyalkylenglykolkonjugate
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
IT1248565B (it) * 1991-06-27 1995-01-19 Erba Carlo Spa Anticorpi policlonali anti-irudina e loro utilizzo per la identificazione, l`immunopurificazione e la determinazione quantitativa dell`uridina.

Also Published As

Publication number Publication date
FI951541A (sv) 1995-03-31
HUT72926A (en) 1996-06-28
AU685835B2 (en) 1998-01-29
ZA945775B (en) 1995-02-06
SG49862A1 (en) 2002-03-19
EP0663009A1 (en) 1995-07-19
NZ271088A (en) 1996-10-28
NO951277D0 (no) 1995-04-03
NO951277L (no) 1995-04-03
CA2144523A1 (en) 1995-02-16
CN1113389A (zh) 1995-12-13
JPH08502661A (ja) 1996-03-26
KR950703645A (ko) 1995-09-20
US5661001A (en) 1997-08-26
WO1995004823A1 (en) 1995-02-16
IL110540A0 (en) 1994-11-11
AU7460594A (en) 1995-02-28
HU9500689D0 (en) 1995-06-28

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Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: NOVARTIS AG