FI945705L - Bisindolyylimaleimidien parannettu synteesi - Google Patents
Bisindolyylimaleimidien parannettu synteesi Download PDFInfo
- Publication number
- FI945705L FI945705L FI945705A FI945705A FI945705L FI 945705 L FI945705 L FI 945705L FI 945705 A FI945705 A FI 945705A FI 945705 A FI945705 A FI 945705A FI 945705 L FI945705 L FI 945705L
- Authority
- FI
- Finland
- Prior art keywords
- bisindolylmaleimides
- improved synthesis
- synthesis
- improved
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/17—Unsaturated ethers containing halogen
- C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
- C07C43/1745—Unsaturated ethers containing halogen containing six-membered aromatic rings having more than one ether bound
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16306093A | 1993-12-07 | 1993-12-07 | |
| US08/317,140 US5541347A (en) | 1993-12-07 | 1994-10-03 | Synthesis of bisindolylmaleimides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI945705A0 FI945705A0 (fi) | 1994-12-02 |
| FI945705A7 FI945705A7 (fi) | 1996-06-03 |
| FI945705L true FI945705L (fi) | 1996-06-03 |
Family
ID=26859319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI945705A FI945705L (fi) | 1993-12-07 | 1994-12-02 | Bisindolyylimaleimidien parannettu synteesi |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5614647A (fi) |
| EP (1) | EP0657411B1 (fi) |
| JP (1) | JPH07238044A (fi) |
| AT (1) | ATE181049T1 (fi) |
| BR (1) | BR9404830A (fi) |
| CA (1) | CA2137205A1 (fi) |
| DE (1) | DE69418978T2 (fi) |
| DK (1) | DK0657411T3 (fi) |
| ES (1) | ES2134910T3 (fi) |
| FI (1) | FI945705L (fi) |
| GR (1) | GR3030722T3 (fi) |
| HU (1) | HUT69164A (fi) |
| IL (1) | IL111851A (fi) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5919946A (en) * | 1996-03-20 | 1999-07-06 | Eli Lilly And Company | Synthesis of indolylmaleimides |
| US6232299B1 (en) | 1996-05-01 | 2001-05-15 | Eli Lilly And Company | Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy |
| UA54427C2 (uk) * | 1996-05-01 | 2003-03-17 | Елі Ліллі Енд Компані | Спосіб лікування очних захворювань, які пов'язані з фактором васкулярного ендотеліального росту |
| AU736333B2 (en) | 1996-05-01 | 2001-07-26 | Eli Lilly And Company | Therapeutic treatment for VEGF related diseases |
| US5962446A (en) * | 1996-08-30 | 1999-10-05 | Eli Lilly And Company | Therapetutic treatment for human T cell lymphotrophic virus type 1 infection |
| US6107327A (en) * | 1996-08-30 | 2000-08-22 | Eli Lilly And Company | Therapeutic treatment for HIV infection |
| US5859261A (en) * | 1997-03-20 | 1999-01-12 | Eli Lilly And Company | Synthesis of indolylmaleimides |
| US6093740A (en) * | 1997-04-30 | 2000-07-25 | Eli Lilly And Company | Therapeutic treatment for skin disorders |
| DE69940423D1 (de) | 1998-01-30 | 2009-04-02 | Daiso Co Ltd | Verfahren zur herstellung von butantriol-derivaten |
| US6103713A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for autoimmune diseases |
| US6225301B1 (en) | 1998-03-05 | 2001-05-01 | Eli Lilly And Company | Therapeutic treatment for renal dysfunction |
| US6103712A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for asthma |
| US6291446B1 (en) | 1998-03-05 | 2001-09-18 | Eli Lilly And Company | Therapeutic treatment for cytomegalovirus infection |
| EP2181999A1 (en) * | 2008-11-03 | 2010-05-05 | Zentiva, A.S. | Method of manufacturing ruboxistarin |
| CN112739345A (zh) | 2017-11-06 | 2021-04-30 | 斯奈普生物公司 | Pim激酶抑制剂组合物，方法和其用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4785085A (en) * | 1986-11-21 | 1988-11-15 | Bristol-Myers Company | Rebeccamycin analogs |
| EP0303697B1 (en) * | 1987-03-09 | 1997-10-01 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of physiologically active substance k-252 |
| US5438050A (en) * | 1988-02-06 | 1995-08-01 | Godecke Aktiengesellschaft | Indolocarbazole derivatives, processes for their preparation and compositions containing them |
| DE3803620A1 (de) * | 1988-02-06 | 1989-08-17 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| SK75289A3 (en) * | 1988-02-10 | 1998-05-06 | Hoffmann La Roche | Substituted pyrroles, their use for producing a drug, and the drug on their base |
| MC2096A1 (fr) * | 1989-02-23 | 1991-02-15 | Hoffmann La Roche | Pyrroles substitues |
| DE3914764A1 (de) * | 1989-05-05 | 1990-11-08 | Goedecke Ag | Maleinimid-derivate und deren verwendung als arzneimittel |
| IL94274A0 (en) * | 1989-05-05 | 1991-03-10 | Goedecke Ag | Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same |
| DE3942296A1 (de) * | 1989-12-21 | 1991-06-27 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung |
| DE4005970A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| DE4005969A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| CA2046801C (en) * | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
| GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
| US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
| AU5100393A (en) * | 1992-09-25 | 1994-04-26 | Schering Corporation | Diindolo compounds and pharmaceutical compositions containing them |
-
1994
- 1994-12-02 DE DE69418978T patent/DE69418978T2/de not_active Expired - Fee Related
- 1994-12-02 FI FI945705A patent/FI945705L/fi unknown
- 1994-12-02 DK DK94308948T patent/DK0657411T3/da active
- 1994-12-02 AT AT94308948T patent/ATE181049T1/de not_active IP Right Cessation
- 1994-12-02 JP JP6299401A patent/JPH07238044A/ja not_active Ceased
- 1994-12-02 HU HU9403467A patent/HUT69164A/hu unknown
- 1994-12-02 BR BR9404830A patent/BR9404830A/pt not_active Application Discontinuation
- 1994-12-02 CA CA002137205A patent/CA2137205A1/en not_active Abandoned
- 1994-12-02 ES ES94308948T patent/ES2134910T3/es not_active Expired - Lifetime
- 1994-12-02 EP EP94308948A patent/EP0657411B1/en not_active Expired - Lifetime
- 1994-12-02 IL IL11185194A patent/IL111851A/en not_active IP Right Cessation
-
1995
- 1995-05-25 US US08/452,613 patent/US5614647A/en not_active Expired - Fee Related
-
1996
- 1996-05-17 US US08/650,922 patent/US5665877A/en not_active Expired - Fee Related
-
1999
- 1999-07-07 GR GR990401805T patent/GR3030722T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3030722T3 (en) | 1999-11-30 |
| HU9403467D0 (en) | 1995-02-28 |
| US5665877A (en) | 1997-09-09 |
| DE69418978D1 (de) | 1999-07-15 |
| DE69418978T2 (de) | 1999-10-28 |
| EP0657411A1 (en) | 1995-06-14 |
| FI945705A7 (fi) | 1996-06-03 |
| US5614647A (en) | 1997-03-25 |
| EP0657411B1 (en) | 1999-06-09 |
| JPH07238044A (ja) | 1995-09-12 |
| ES2134910T3 (es) | 1999-10-16 |
| DK0657411T3 (da) | 1999-11-15 |
| BR9404830A (pt) | 1995-08-08 |
| IL111851A (en) | 1998-09-24 |
| ATE181049T1 (de) | 1999-06-15 |
| IL111851A0 (en) | 1995-03-15 |
| FI945705A0 (fi) | 1994-12-02 |
| CA2137205A1 (en) | 1995-06-08 |
| HUT69164A (en) | 1995-08-28 |
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