FI94346B - Förfarande för framställning av omättade aminodikarboxylsyraderivat - Google Patents
Förfarande för framställning av omättade aminodikarboxylsyraderivat Download PDFInfo
- Publication number
- FI94346B FI94346B FI901709A FI901709A FI94346B FI 94346 B FI94346 B FI 94346B FI 901709 A FI901709 A FI 901709A FI 901709 A FI901709 A FI 901709A FI 94346 B FI94346 B FI 94346B
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- Prior art keywords
- formula
- alkoxycarbonyl
- salts
- amino
- compounds
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- 238000000034 method Methods 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims description 17
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3826—Acyclic unsaturated acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Claims (8)
1. Förfarande för framställning av terapeutiskt användba-ra föreningar med formeln I o ho^ Il ^ r2 HO"P Ύ α)· och salter därav, i vilken formel A betecknar en tvävärd alifatisk kolväterest med 2 kolatomer och Rt och Rj obero-ende av varandra betecknar fria eller förestrade karboxi-grupper, kännetecknat därav, att i en före-ning med formeln II o zi\11 ^ 2 I (II), ¾ ,A z3 Ri väri Z, och Z2 betecknar en eventuellt skyddad hydroxi och Z3 betecknar en skyddad amino, Z3 omvandlas tili amino och den skyddade hydroxin Zx och/eller Z2, om närvarande, omvandlas tili hydroxi, och den erhällna föreningen omvandlas, om sk önskas, tili en annan förening med formeln I, en enligt förfarandet erhällbar isomerblandning uppdelas ·; i komponenter och den isomer, som i varje enskilt fall anses vara den bästa, ätskiljs och/eller en enligt förfarandet erhällbar fri förening omvandlas tili ett sait eller ett enligt förfarandet erhällbart salt tili en mot-svarande fri förening.
2. Förfarande enligt patentkravet 1 för framställning av föreningar med formeln I enligt patentkravet 1 och salter därav, i vilka A betecknar lägalkylen eller lägalkenylen med 2 kolatomer och R, och R2 oberoende av varandra betecknar karboxi, lägalkoxikarbonyl eller fenyllägalkoxi-karbonyl, som eventuellt är substituerad med lägalkyl, 24 Q A Z A C -j- ο n 0 lägalkoxi, halogen, cyano och/eller trifluormetyl.
3. Förfarande enligt patentkravet 1 för framställning av föreningar med formeln I enligt patentkravet 1 och salter därav, i vilka A betecknar 1,2-etylen eller 1,2-vinylen, Rt betecknar karboxi, C,-C4-alkoxikarbonyl eller fenyl-C,-C4-alkoxikarbonyl som eventuellt är substituerad med C^-C^-alkyl, C,-C4-alkoxi, halogen vars ordningstal är högst 35, cyano och/eller trifluormetyl, och R2 betecknar karboxi, C,-C4-alkoxikarbonyl eller fenyl-C^-Qj-alkoxikarbonyl som eventuellt är substituerad med C^-Q-alkyl, Ct-C4-alkoxi, halogen, vars ordningstal är högst 35, och/eller tri- fluormetyl.
4. Förfarande enligt patentkravet 1 för framställning av föreningar med formeln I enligt patentkravet 1 och salter därav, i vilka A betecknar 1,2-etylen, Rj betecknar karboxi, C,-C4-alkoxikarbonyl eller fenyl-C^-Qj-alkoxikarbo-nyl, som eventuellt är substituerad med C,-C4-alkyl, C,-C4-alkoxi, halogen, vars ordningstal är högst 35, cyano och/eller trif luormetyl, och R2 betecknar karboxi, C,-C4-alkoxikarbonyl eller fenyl-Ci-C4-alkoxikarbonyl, som eventuellt är substituerad med Cj-^-alkyl, C^-Q-alkoxi, halogen, vars ordningstal är högst 35, och/eller trifluormetyl.
5. Förfarande enligt patentkravet 1 för framställning av föreningar med formeln I enligt patentkravet 1 och salter därav, i vilka A betecknar 1,2-etylen och R! och Rj betecknar lika eller olika C,-C4-alkoxikarbonyl- eller fenyl-Cj-C4-alkoxikarbonylgrupper.
6. Förfarande enligt patentkravet 1 för framställning av E-2-amino-4-fosfonometyl-hept-3-en-l,7-disyradietylester eller ett sait därav.
7. Förfarande enligt patentkravet 1 för framställning av ο r. t a c / -f o 0 25 E-2-amino-4-fosfonometyl-hept-3-en-l,7-disyra eller ett salt därav.
8. Förfarande enligt patentkravet 1 för framställning av E-2-amino-4-fosfonometyl-hept-3-en-l,7-disyradibensyles-ter eller ett salt därav.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH131789 | 1989-04-07 | ||
| CH131789 | 1989-04-07 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI901709A0 FI901709A0 (sv) | 1990-04-04 |
| FI901709A FI901709A (sv) | 1991-10-05 |
| FI94346B true FI94346B (sv) | 1995-05-15 |
| FI94346C FI94346C (sv) | 1995-08-25 |
Family
ID=4207615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI901709A FI94346C (sv) | 1989-04-07 | 1990-04-04 | Förfarande för framställning av omättade aminodikarboxylsyraderivat |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5134134A (sv) |
| EP (1) | EP0391850B1 (sv) |
| JP (1) | JPH02290889A (sv) |
| KR (1) | KR900016240A (sv) |
| AT (1) | ATE112282T1 (sv) |
| AU (1) | AU639450B2 (sv) |
| CA (1) | CA2013919A1 (sv) |
| DD (1) | DD298931A5 (sv) |
| DE (1) | DE59007300D1 (sv) |
| DK (1) | DK0391850T3 (sv) |
| ES (1) | ES2060122T3 (sv) |
| FI (1) | FI94346C (sv) |
| HU (1) | HU207336B (sv) |
| IE (1) | IE65571B1 (sv) |
| IL (1) | IL93960A (sv) |
| MX (1) | MX20200A (sv) |
| NO (1) | NO176913C (sv) |
| NZ (1) | NZ233220A (sv) |
| PT (1) | PT93675B (sv) |
| ZA (1) | ZA902636B (sv) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5175344A (en) * | 1986-02-13 | 1992-12-29 | Ciba-Geigy Corporation | Unsaturated amino acids |
| DE59007300D1 (de) * | 1989-04-07 | 1994-11-03 | Ciba Geigy Ag | Ungesättigte Aminodicarbonsäurederivate. |
| US5488140A (en) * | 1989-09-26 | 1996-01-30 | Ciba-Geigy Corporation | 4-substituted 2-aminoalk-3-enoic |
| US5294734A (en) * | 1989-09-26 | 1994-03-15 | Ciba-Geigy Corp. | 4-substituted 2-aminoalk-3-enoic acids |
| EP3427729A1 (en) | 2017-07-13 | 2019-01-16 | Paris Sciences et Lettres - Quartier Latin | Probenecid for use in treating epileptic diseases, disorders or conditions |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5387314A (en) * | 1977-01-07 | 1978-08-01 | Heiichi Sakai | Nn14099substance |
| EP0030424B1 (en) * | 1979-12-08 | 1985-02-20 | Hoechst Aktiengesellschaft | Derivatives of 4-(methylphosphinyl)-2-oxobutanoic acid, herbicidal compositions containing them, and intermediates and methods for their production |
| US4466913A (en) * | 1981-06-30 | 1984-08-21 | Maiji Seika Kaisha Ltd. | Phosphorus-containing compounds and process for producing the same |
| US4477391A (en) * | 1981-08-14 | 1984-10-16 | Collins James F | Amino acid isomers, their production and their medicinal use |
| DE3663666D1 (en) * | 1985-03-28 | 1989-07-06 | Hoechst Ag | Functional derivatives of phosphorus containing acetic acids, process for their preparation and herbicidal and plant growth regulator composition containing them |
| ATE70535T1 (de) * | 1986-02-13 | 1992-01-15 | Ciba Geigy Ag | Ungesaettigte aminosaeuren. |
| DE3609818A1 (de) * | 1986-03-22 | 1987-09-24 | Hoechst Ag | Verfahren zur herstellung von l-phosphinothricin(derivaten) sowie ihrer alkylester |
| US4657899A (en) * | 1986-04-09 | 1987-04-14 | Nova Pharmaceutical Corporation | Antagonists of specific excitatory amino acid neurotransmitter receptors |
| US4761405A (en) * | 1987-03-04 | 1988-08-02 | Nova Pharmaceutical Corporation | Antagonists of specific excitatory amino acid neurotransmitter receptors having increased potency |
| EP0302826A3 (de) * | 1987-08-04 | 1991-04-03 | Ciba-Geigy Ag | Verfahren zur Herstellung neuer ungesättigter Aminosäureverbindungen |
| DE59007300D1 (de) * | 1989-04-07 | 1994-11-03 | Ciba Geigy Ag | Ungesättigte Aminodicarbonsäurederivate. |
| US4916125A (en) * | 1989-07-11 | 1990-04-10 | Sandoz Ltd. | Method of treating migraine |
| ES2074153T3 (es) * | 1989-09-26 | 1995-09-01 | Ciba Geigy Ag | Acidos fosfonicos, procedimiento para su obtencion y empleo como productos activos para medicamentos. |
-
1990
- 1990-03-29 DE DE59007300T patent/DE59007300D1/de not_active Expired - Fee Related
- 1990-03-29 ES ES90810253T patent/ES2060122T3/es not_active Expired - Lifetime
- 1990-03-29 AT AT90810253T patent/ATE112282T1/de active
- 1990-03-29 EP EP90810253A patent/EP0391850B1/de not_active Expired - Lifetime
- 1990-03-29 DK DK90810253.6T patent/DK0391850T3/da not_active Application Discontinuation
- 1990-03-30 IL IL9396090A patent/IL93960A/en not_active IP Right Cessation
- 1990-04-04 FI FI901709A patent/FI94346C/sv not_active IP Right Cessation
- 1990-04-04 KR KR1019900004639A patent/KR900016240A/ko not_active Application Discontinuation
- 1990-04-05 CA CA002013919A patent/CA2013919A1/en not_active Abandoned
- 1990-04-05 AU AU52931/90A patent/AU639450B2/en not_active Ceased
- 1990-04-05 MX MX20200A patent/MX20200A/es unknown
- 1990-04-05 PT PT93675A patent/PT93675B/pt not_active IP Right Cessation
- 1990-04-05 ZA ZA902636A patent/ZA902636B/xx unknown
- 1990-04-05 NZ NZ233220A patent/NZ233220A/en unknown
- 1990-04-06 IE IE125590A patent/IE65571B1/en not_active IP Right Cessation
- 1990-04-06 DD DD90339533A patent/DD298931A5/de not_active IP Right Cessation
- 1990-04-06 NO NO901579A patent/NO176913C/no unknown
- 1990-04-06 JP JP2090509A patent/JPH02290889A/ja active Pending
- 1990-04-06 HU HU902114A patent/HU207336B/hu not_active IP Right Cessation
-
1991
- 1991-05-13 US US07/699,412 patent/US5134134A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0391850B1 (de) | 1994-09-28 |
| IL93960A0 (en) | 1990-12-23 |
| HUT53658A (en) | 1990-11-28 |
| EP0391850A3 (de) | 1991-03-13 |
| HU207336B (en) | 1993-03-29 |
| MX20200A (es) | 1994-05-31 |
| PT93675B (pt) | 1996-08-30 |
| HU902114D0 (en) | 1990-07-28 |
| EP0391850A2 (de) | 1990-10-10 |
| NZ233220A (en) | 1992-08-26 |
| DK0391850T3 (da) | 1994-10-24 |
| IL93960A (en) | 1994-08-26 |
| US5134134A (en) | 1992-07-28 |
| DD298931A5 (de) | 1992-03-19 |
| CA2013919A1 (en) | 1990-10-07 |
| DE59007300D1 (de) | 1994-11-03 |
| AU5293190A (en) | 1990-10-11 |
| FI901709A (sv) | 1991-10-05 |
| NO901579D0 (no) | 1990-04-06 |
| ZA902636B (en) | 1990-12-28 |
| KR900016240A (ko) | 1990-11-13 |
| JPH02290889A (ja) | 1990-11-30 |
| FI94346C (sv) | 1995-08-25 |
| ATE112282T1 (de) | 1994-10-15 |
| NO176913C (no) | 1995-06-21 |
| PT93675A (pt) | 1990-11-20 |
| FI901709A0 (sv) | 1990-04-04 |
| AU639450B2 (en) | 1993-07-29 |
| NO901579L (no) | 1990-10-08 |
| IE65571B1 (en) | 1995-11-01 |
| IE901255L (en) | 1990-10-07 |
| NO176913B (no) | 1995-03-13 |
| ES2060122T3 (es) | 1994-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| PC | Transfer of assignment of patent |
Owner name: NOVARTIS AG |
|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: NOVARTIS AG |