FI943275A - TIE, uusi endoteelisolun reseptorityrosiinikinaasi - Google Patents

TIE, uusi endoteelisolun reseptorityrosiinikinaasi Download PDF

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Publication number
FI943275A
FI943275A FI943275A FI943275A FI943275A FI 943275 A FI943275 A FI 943275A FI 943275 A FI943275 A FI 943275A FI 943275 A FI943275 A FI 943275A FI 943275 A FI943275 A FI 943275A
Authority
FI
Finland
Prior art keywords
tie
tyrosine kinase
endothelial cell
cell receptor
receptor tyrosine
Prior art date
Application number
FI943275A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI943275A0 (fi
Inventor
Juha Partanen
Elina Armstrong
Tomi P Maekelae
Jaana Korhonen
Kari Alitalo
Original Assignee
Helsinki University Holding Lt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helsinki University Holding Lt filed Critical Helsinki University Holding Lt
Priority to FI943275A priority Critical patent/FI943275A/fi
Publication of FI943275A0 publication Critical patent/FI943275A0/fi
Publication of FI943275A publication Critical patent/FI943275A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI943275A 1992-01-09 1994-07-08 TIE, uusi endoteelisolun reseptorityrosiinikinaasi FI943275A (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI943275A FI943275A (fi) 1992-01-09 1994-07-08 TIE, uusi endoteelisolun reseptorityrosiinikinaasi

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81780092A 1992-01-09 1992-01-09
PCT/FI1993/000006 WO1993014124A1 (en) 1992-01-09 1993-01-08 Tie, a novel endothelial cell receptor tyrosine kinase
FI943275A FI943275A (fi) 1992-01-09 1994-07-08 TIE, uusi endoteelisolun reseptorityrosiinikinaasi

Publications (2)

Publication Number Publication Date
FI943275A0 FI943275A0 (fi) 1994-07-08
FI943275A true FI943275A (fi) 1994-07-11

Family

ID=25223909

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943275A FI943275A (fi) 1992-01-09 1994-07-08 TIE, uusi endoteelisolun reseptorityrosiinikinaasi

Country Status (8)

Country Link
EP (1) EP0620826A1 (ja)
JP (1) JPH07506242A (ja)
KR (1) KR940703857A (ja)
AU (1) AU3353293A (ja)
CA (1) CA2127540A1 (ja)
FI (1) FI943275A (ja)
HU (1) HUT69792A (ja)
WO (1) WO1993014124A1 (ja)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955291A (en) * 1992-01-09 1999-09-21 Alitalo; Kari Antibodies recognizing tie receptor tyrosine kinase and uses thereof
US6107046A (en) * 1992-10-09 2000-08-22 Orion Corporation Antibodies to Flt4, a receptor tyrosine kinase and uses thereof
US5776755A (en) * 1992-10-09 1998-07-07 Helsinki University Licensing, Ltd. FLT4, a receptor tyrosine kinase
US6824777B1 (en) 1992-10-09 2004-11-30 Licentia Ltd. Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
JPH08504760A (ja) * 1992-10-30 1996-05-21 ルードヴィッヒ・インスティテュート・フォア・キャンサー・リサーチ 新規なタンパク質チロシンキナーゼ
US6001621A (en) * 1993-11-23 1999-12-14 Genetech, Inc. Protein tyrosine kinases
WO1995014776A1 (en) * 1993-11-23 1995-06-01 Genentech, Inc. PROTEIN TYROSINE KINASES NAMED Rse
US5536641A (en) * 1994-05-17 1996-07-16 Memorial Sloane Kittering Cancer Center Monoclonal antibody specific for vascular endothelial cell antigen endoglyx-1 and uses thereof for detection of, and isolation of, vascular endothelial cells
US5585269A (en) * 1994-06-02 1996-12-17 The University Of North Carolina At Chapel Hill Isolated DNA encoding c-mer protooncogene
WO1995033772A1 (en) * 1994-06-09 1995-12-14 Kari Alitalo Flt4 receptor tyrosine kinase and its use in diagnosis and therapy
JPH10506011A (ja) * 1994-09-22 1998-06-16 ヘルシンキ、ユニバーシティ、ライセンシング、リミテッド、オサケ、ユキチュア レセプターチロシンキナーゼ、ｔｉｅのプロモーター
US5722638A (en) * 1995-10-20 1998-03-03 Vemco Corporation Valve with means to block relative rotation of parts during assembly
US5972338A (en) 1997-09-19 1999-10-26 Genentech, Inc. Tie ligands homologues
US6057435A (en) 1997-09-19 2000-05-02 Genentech, Inc. Tie ligand homologues
US6350450B1 (en) 1997-09-19 2002-02-26 Genentech, Inc. TIE ligand homologue antibody
US6348350B1 (en) 1997-09-19 2002-02-19 Genentech, Inc. Ligand homologues
US6030831A (en) * 1997-09-19 2000-02-29 Genetech, Inc. Tie ligand homologues
US6365154B1 (en) * 1998-09-28 2002-04-02 Smithkline Beecham Corporation Tie2 agonist antibodies
ATE489108T1 (de) 1998-10-09 2010-12-15 Vegenics Ltd Flt4 (vegfr-3) als ziel für tumornachweis (imaging) und antitumortherapie
US7393823B1 (en) 1999-01-20 2008-07-01 Oregon Health And Science University HER-2 binding antagonists
US7396810B1 (en) 2000-08-14 2008-07-08 Oregon Health Sciences University Compositions and methods for treating cancer by modulating HER-2 and EGF receptors
US6521424B2 (en) 1999-06-07 2003-02-18 Immunex Corporation Recombinant expression of Tek antagonists
ATE324444T1 (de) 1999-06-07 2006-05-15 Immunex Corp Tek-antagonisten
EP1953173B1 (en) 1999-06-15 2009-11-18 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids endoding the same
ATE359300T1 (de) 2001-01-19 2007-05-15 Ludwig Inst Cancer Res Flt4 (vegfr-3) als ein ziel für krebs darstellung und anti-krebs-behandlung
US7871610B2 (en) 2003-08-12 2011-01-18 Dyax Corp. Antibodies to Tie1 ectodomain
US7485297B2 (en) 2003-08-12 2009-02-03 Dyax Corp. Method of inhibition of vascular development using an antibody
CA2535171A1 (en) 2003-08-12 2005-03-03 Dyax Corp. Tie1-binding ligands
PT2956476T (pt) 2013-02-18 2020-02-21 Vegenics Pty Ltd Moléculas de ligação e usos destas

Also Published As

Publication number Publication date
HUT69792A (en) 1995-09-28
JPH07506242A (ja) 1995-07-13
HU9402057D0 (en) 1994-09-28
FI943275A0 (fi) 1994-07-08
KR940703857A (ko) 1994-12-12
WO1993014124A1 (en) 1993-07-22
EP0620826A1 (en) 1994-10-26
CA2127540A1 (en) 1993-07-22
AU3353293A (en) 1993-08-03

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