FI941459A0 - Tuumorinekroositekijän muteiineja - Google Patents

Tuumorinekroositekijän muteiineja

Info

Publication number
FI941459A0
FI941459A0 FI941459A FI941459A FI941459A0 FI 941459 A0 FI941459 A0 FI 941459A0 FI 941459 A FI941459 A FI 941459A FI 941459 A FI941459 A FI 941459A FI 941459 A0 FI941459 A0 FI 941459A0
Authority
FI
Finland
Prior art keywords
necrosis factor
tumor necrosis
muteins
factor muteins
tumor
Prior art date
Application number
FI941459A
Other languages
English (en)
Swedish (sv)
Other versions
FI941459A (fi
Inventor
David Banner
Werner Lesslauer
Hansruedi Loetscher
Dietrich Stueber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI941459A0 publication Critical patent/FI941459A0/fi
Publication of FI941459A publication Critical patent/FI941459A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
FI941459A 1993-03-29 1994-03-29 Tuumorinekroositekijän muteiineja FI941459A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93810224 1993-03-29

Publications (2)

Publication Number Publication Date
FI941459A0 true FI941459A0 (fi) 1994-03-29
FI941459A FI941459A (fi) 1994-09-30

Family

ID=8214942

Family Applications (1)

Application Number Title Priority Date Filing Date
FI941459A FI941459A (fi) 1993-03-29 1994-03-29 Tuumorinekroositekijän muteiineja

Country Status (14)

Country Link
US (1) US5597899A (fi)
EP (1) EP0619372A1 (fi)
JP (1) JPH089976A (fi)
CN (1) CN1099802A (fi)
AU (1) AU5901994A (fi)
BR (1) BR9401321A (fi)
CA (1) CA2119089A1 (fi)
CZ (1) CZ67694A3 (fi)
FI (1) FI941459A (fi)
HU (1) HUT68218A (fi)
IL (1) IL109094A0 (fi)
NO (1) NO941142L (fi)
NZ (1) NZ260146A (fi)
RU (1) RU94009852A (fi)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2253557A1 (en) * 1996-05-08 1997-11-13 Louis Martin Renzetti Treatment of asthma with tnfr-ig
SI0975668T1 (sl) 1997-04-15 2007-02-28 Pharmexa As Modificirana molekula TNFalfa, DNA, ki kodira tako modificirano molekulo TNFalfa in cepivo, ki vsebuje tako modificirano molekulo TNFalfa in DNA
CN1062274C (zh) * 1997-10-07 2001-02-21 复旦大学 人肿瘤坏死因子α衍生物及其制备方法
US6354297B1 (en) * 1998-04-16 2002-03-12 The Uniformed Services University Of The Health Sciences Method and device for destroying fat cells by induction of programmed cell death
US6620382B1 (en) * 1998-05-22 2003-09-16 Biopheresis Technologies, Llc. Method and compositions for treatment of cancers
US8197430B1 (en) * 1998-05-22 2012-06-12 Biopheresis Technologies, Inc. Method and system to remove cytokine inhibitor in patients
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US6379708B1 (en) * 1999-11-20 2002-04-30 Cytologic, Llc Method for enhancing immune responses in mammals
US7687461B2 (en) * 2000-03-02 2010-03-30 Xencor, Inc. Treatment of TNF-α related disorders with TNF-α variant proteins
US7446174B2 (en) 2001-03-02 2008-11-04 Xencor, Inc. Protein based TNF-α variants for the treatment of TNF-α related disorders
US20070172449A1 (en) * 2000-03-02 2007-07-26 Xencor, Inc. TNF-alpha VARIANT FORMULATIONS FOR THE TREATMENT OF TNF-alpha RELATED DISORDERS
US7662367B2 (en) * 2000-03-02 2010-02-16 Xencor, Inc. Pharmaceutical compositions for the treatment of TNF-α related disorders
US7244823B2 (en) * 2000-03-02 2007-07-17 Xencor TNF-alpha variants proteins for the treatment of TNF-alpha related disorders
US7056695B2 (en) 2000-03-02 2006-06-06 Xencor TNF-α variants
US7101974B2 (en) 2000-03-02 2006-09-05 Xencor TNF-αvariants
WO2003057856A2 (en) * 2002-01-04 2003-07-17 Xencor Dominant negative proteins and methods thereof
JP4177604B2 (ja) * 2002-03-25 2008-11-05 株式会社林原生物化学研究所 生理活性複合体
US7179891B2 (en) * 2002-03-25 2007-02-20 Tadanori Mayumi Physiologically active complex
DE60333228D1 (de) * 2002-12-02 2010-08-12 Amgen Fremont Inc Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen
EP1628618A4 (en) * 2002-12-26 2009-09-09 Mountain View Pharmaceuticals POLYMER CONJUGATES OF CYTOKINES, CHEMOKINS, GROWTH FACTORS, POLYPEPTIDE HORMONES AND ANTAGONISTS THEREOF WITH PRESERVED RECEPTOR BINDING ACTIVITY
US7642340B2 (en) * 2003-03-31 2010-01-05 Xencor, Inc. PEGylated TNF-α variant proteins
CA2542353A1 (en) * 2003-10-10 2005-04-21 Xencor, Inc. Protein based tnf-alpha variants for the treatment of tnf-alpha related disorders
TW200526780A (en) * 2004-01-06 2005-08-16 Hayashibara Biochem Lab TNF antagonists and TNF inhibitors comprising the same as the active ingredient
AU2005240082B2 (en) * 2004-04-30 2009-07-23 Innatus Corporation Method and system to remove soluble TNFR1,TNFR2, and IL2 in patients
GB0425972D0 (en) 2004-11-25 2004-12-29 Celltech R&D Ltd Biological products
US20070065514A1 (en) * 2005-09-22 2007-03-22 Howell Mark D Method for enhancing immune responses in mammals
US20080075690A1 (en) * 2006-09-22 2008-03-27 Mark Douglas Howell Method for enhancing immune responses in mammals
WO2008127515A1 (en) * 2007-03-01 2008-10-23 Cytologic, Inc. Compositions and method for enhancing immune responses in mammals
GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy
CN106540252B (zh) * 2016-12-07 2020-04-28 四川大学 针对肿瘤坏死因子α的蛋白疫苗及其用途
GB201621907D0 (en) 2016-12-21 2017-02-01 Ucb Biopharma Sprl And Sanofi Antibody epitope
JP7370580B2 (ja) * 2017-04-06 2023-10-30 ウニヴェルズィテート シュトゥットガルト 結合および生物活性を改善した腫瘍壊死因子受容体（ｔｎｆｒ）結合タンパク質複合体
US11957825B2 (en) 2021-06-17 2024-04-16 Immunicom Inc. Modified TNF as a capture ligand

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
DE19975063I2 (de) * 1984-03-06 2005-08-18 Dainippon Pharmaceutical Co DNS den menschlichen Tumornekrosisfaktor kodierendund das menschliche Tumornekronisfaktor-Polypepti d.
GR851626B (fi) * 1984-07-05 1985-11-26 Genentech Inc
US4650674A (en) * 1984-07-05 1987-03-17 Genentech, Inc. Synergistic cytotoxic composition
DE3750056T2 (de) * 1986-06-20 1995-04-06 Dainippon Pharmaceutical Co Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS.
JPH07106158B2 (ja) * 1986-12-04 1995-11-15 サントリー株式会社 抗腫瘍活性を有する新規ポリペプチドおよびその製造法
AU1346488A (en) * 1987-02-26 1988-09-26 Cetus Corporation Arginine-depleted human tumor necrosis factor
DE3843534A1 (de) * 1988-12-23 1990-07-12 Basf Ag Neue tnf-polypeptide
CA2055168A1 (en) * 1990-11-21 1992-05-22 Walter Fiers Tnf-muteins
IL99120A0 (en) * 1991-08-07 1992-07-15 Yeda Res & Dev Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them
CZ283533B6 (cs) * 1992-04-02 1998-04-15 F. Hoffmann-La Roche Ag TNF - muteiny a způsob jejich výroby

Also Published As

Publication number Publication date
BR9401321A (pt) 1994-10-18
AU5901994A (en) 1994-10-06
CA2119089A1 (en) 1994-09-30
FI941459A (fi) 1994-09-30
CN1099802A (zh) 1995-03-08
HUT68218A (en) 1995-06-28
US5597899A (en) 1997-01-28
HU9400829D0 (en) 1994-06-28
JPH089976A (ja) 1996-01-16
NO941142D0 (no) 1994-03-28
IL109094A0 (en) 1994-06-24
CZ67694A3 (en) 1995-02-15
EP0619372A1 (en) 1994-10-12
NZ260146A (en) 1995-10-26
NO941142L (no) 1994-09-30
RU94009852A (ru) 1996-07-20

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