FI933213A7 - Uudet bentsimidatsolin piperidiinijohdannaiset - Google Patents

Uudet bentsimidatsolin piperidiinijohdannaiset Download PDF

Info

Publication number
FI933213A7
FI933213A7 FI933213A FI933213A FI933213A7 FI 933213 A7 FI933213 A7 FI 933213A7 FI 933213 A FI933213 A FI 933213A FI 933213 A FI933213 A FI 933213A FI 933213 A7 FI933213 A7 FI 933213A7
Authority
FI
Finland
Prior art keywords
benzimidazolines
piperidine derivatives
new piperidine
new
derivatives
Prior art date
Application number
FI933213A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI933213A0 (fi
FI933213L (fi
Inventor
Aurelio Orjales-Venero
Victor Rubio-Royo
Original Assignee
Fabrica Espanola De Productos Quim Y
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabrica Espanola De Productos Quim Y filed Critical Fabrica Espanola De Productos Quim Y
Publication of FI933213A0 publication Critical patent/FI933213A0/fi
Publication of FI933213L publication Critical patent/FI933213L/fi
Publication of FI933213A7 publication Critical patent/FI933213A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
FI933213A 1992-07-20 1993-07-15 Uudet bentsimidatsolin piperidiinijohdannaiset FI933213A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09201512A ES2048109B1 (es) 1992-07-20 1992-07-20 Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.

Publications (3)

Publication Number Publication Date
FI933213A0 FI933213A0 (fi) 1993-07-15
FI933213L FI933213L (fi) 1994-01-21
FI933213A7 true FI933213A7 (fi) 1994-01-21

Family

ID=8277712

Family Applications (1)

Application Number Title Priority Date Filing Date
FI933213A FI933213A7 (fi) 1992-07-20 1993-07-15 Uudet bentsimidatsolin piperidiinijohdannaiset

Country Status (14)

Country Link
US (1) US5322850A (enExample)
EP (1) EP0580541B1 (enExample)
JP (1) JPH07291964A (enExample)
KR (1) KR940005609A (enExample)
AT (1) ATE185344T1 (enExample)
AU (1) AU667920B2 (enExample)
CA (1) CA2100503C (enExample)
DE (1) DE69326650T2 (enExample)
ES (1) ES2048109B1 (enExample)
FI (1) FI933213A7 (enExample)
MX (1) MX9304215A (enExample)
NO (1) NO303014B1 (enExample)
TW (1) TW225529B (enExample)
ZA (1) ZA935195B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3112290B2 (ja) * 1990-12-14 2000-11-27 メレルダウファーマスーティカルズ インコーポレイテッド 抗アレルギー化合物
KR100362620B1 (ko) 1994-08-25 2003-02-14 메렐 파마슈티칼스 인크. 알레르기성질환치료에유용한치환된피페리딘,이를포함하는약제학적조성물및이의제조방법
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
KR100494448B1 (ko) * 1996-06-04 2005-12-02 화브리까 에스파놀라 데 프로둑또스 뀌미꼬스 이 화르마세우띠꼬스 쏘시에떼 아노님 항히스타민활성을가지는신규한벤조이미다졸유도체
ES2124167B1 (es) * 1996-06-04 1999-09-16 Espanola Prod Quimicos Nuevos derivados del bencimidazol con actividad antihistaminica.
US6136807A (en) * 1998-11-10 2000-10-24 3M Innovative Properties Company Composition for the transdermal delivery of lerisetron
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
US7105505B2 (en) 2002-04-18 2006-09-12 Schering Corporation Benzimidazole derivatives useful as histamine H3 antagonists
WO2003088967A1 (en) * 2002-04-18 2003-10-30 Schering Corporation (1-4-piperidinyl) benzimidazole derivatives useful as histamine h3 antagonists
JP4355917B2 (ja) 2003-10-29 2009-11-04 信越化学工業株式会社 含窒素有機化合物、レジスト材料及びパターン形成方法
EP2240464A4 (en) 2008-02-12 2011-09-14 Yuhan Corp PROCESS FOR THE PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS
WO2013045028A1 (en) * 2011-09-26 2013-04-04 Merck Patent Gmbh Benzyl piperidine compounds as lysophosphatidic acid (lpa) receptor antagonist
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
EP3040334A1 (en) * 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106146308A (zh) * 2015-04-09 2016-11-23 南京长澳医药科技有限公司 α,α-二甲基-4-（2-卤乙酰基）苯乙酸酯的纯化方法
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
HUE053233T2 (hu) 2017-10-16 2021-06-28 Faes Farma Sa Bilasztint és mometanzont tartalmazó vizes készítmények
KR102695627B1 (ko) 2018-01-18 2024-08-16 파에스 파마, 에스.에이. 빌라스틴, 베타-시클로덱스트린 및 적어도 하나의 겔화제를 포함하는 안과용 조성물
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
CR20230109A (es) 2020-07-30 2023-05-11 Faes Farma Sa Sistema de liberación de fármacos descongestivos y bilastina
JP2025508704A (ja) 2022-02-17 2025-04-10 ファエス・ファルマ・ソシエダッド・アノニマ １日１回非経口投与のためのビラスチン組成物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5879983A (ja) * 1981-11-06 1983-05-13 Kanebo Ltd 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
ES8604934A1 (es) * 1985-11-19 1986-03-01 Inke Sa Procedimiento para la obtencion de la 1-((4-fluorfenil)me- til)-n-(1-(2-(4-metoxifenil)etil)-4-piperidinil)-1h-bencimi-dazol-2-amina
US5215974A (en) * 1986-11-21 1993-06-01 Aktiebolaget Hassle Certain pyridyl[(methylthio- or methyl sulfinyl)-2 benzimidazol-2-yl]N-methyl phosphonates useful for treating gastric-acid secretion related diseases
US4988689A (en) * 1987-07-01 1991-01-29 Janssen Pharmaceutica N.V. ((Pharmacologically active bicyclic heterocyclic)methyl and -heteroatom) substituted hexahydro-1H-azepines and pyrrolidines
NZ238863A (en) * 1990-07-19 1993-03-26 Janssen Pharmaceutica Nv Substituted thiazolyl and pyridinyl derivatives
FR2668150B1 (fr) * 1990-10-17 1994-11-18 Theramex Nouveaux derives du terbutylphenyl 1-amino 4-hydroxybutane, leurs procedes de preparation et les compositions pharmaceutiques en renfermant.

Also Published As

Publication number Publication date
AU4194693A (en) 1994-01-27
FI933213A0 (fi) 1993-07-15
CA2100503C (en) 1998-09-29
EP0580541B1 (en) 1999-10-06
DE69326650D1 (de) 1999-11-11
FI933213L (fi) 1994-01-21
NO303014B1 (no) 1998-05-18
US5322850A (en) 1994-06-21
JPH07291964A (ja) 1995-11-07
AU667920B2 (en) 1996-04-18
NO932607D0 (no) 1993-07-19
MX9304215A (es) 1994-02-28
NO932607L (no) 1994-01-21
TW225529B (enExample) 1994-06-21
ZA935195B (en) 1994-09-19
DE69326650T2 (de) 2000-06-08
ES2048109B1 (es) 1994-12-16
KR940005609A (ko) 1994-03-21
EP0580541A1 (en) 1994-01-26
CA2100503A1 (en) 1994-01-21
ATE185344T1 (de) 1999-10-15
ES2048109A1 (es) 1994-03-01

Similar Documents

Publication Publication Date Title
FI933213A7 (fi) Uudet bentsimidatsolin piperidiinijohdannaiset
FI944800L (fi) Indoli-2-karboksyylihappojohdannaisia
FI935223A0 (fi) RAKE-mottagare med selektiv kombinering av straolar
NO932127D0 (no) Imidatderivater av farmasoeytisk nyttige antikonvulserendesulfamater
FI931408A0 (fi) Anordning foer fraesning av amorfiska staolremsor
NO981434D0 (no) Fremgangsmåte for fremstilling av piperidinderivater
FI924353L (fi) Foerfarande foer framstaellning av nya acylaler av imidazol-5-karboxylsyraderivat
FI932028L (fi) Foerfarande foer framstaellning av nya n-aralkyl- och n-heteroaralkylaminoalkanfosfinsyror
FI931023L (fi) Nya b-aminosyraderivat
FI932640L (fi) Nya rodiuminnehaollande selektiva katalyter foer en syntes av epoxisiloxan/epoxisilikonmonomerer och -polymerer
DE69325073D1 (de) Borazinderivate von Hydridopolysilazanpolymeren
FI933443A7 (fi) 4-hydroksikumariinijohdannaisia
FI944016A0 (fi) Makrolidien fluorisokerijohdannaiset
FI934076L (fi) Nya tiomarinolderivat och foerfaranden foer framstaellning av dessa
FI932511A7 (fi) Nya tiosemikarbazonderivat
NO940190D0 (no) Anvendelse av x-ketoglutarat
FI933165A7 (fi) Nya fosfolipidderivat
NO920272D0 (no) Hydrofile-hydrofobe derivater av polygalaktomannaner inneholdende tertiaer aminfunksjonalitet
FI944015L (fi) Makrolidien 2-aminosokerijohdannaiset
FI922425L (fi) Nya 14-kron-4-eterderivat
LV10088A (lv) Jauni fenilsulfonilakrilestera atvasinajumi
FI930987L (fi) Nya prostaglandin-i2-derivat
SE8800027D0 (sv) Foerbaettra saekerheten foer intraang av bostaeder
BR9306699A (pt) Derivados do triazoliletanol
SE8800420D0 (sv) Lokalisering av foremal