FI92353B - Förfarande, testanordning och testförpackning för snabb bestämning med synbar utläsning - Google Patents

Förfarande, testanordning och testförpackning för snabb bestämning med synbar utläsning Download PDF

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Publication number
FI92353B
FI92353B FI880788A FI880788A FI92353B FI 92353 B FI92353 B FI 92353B FI 880788 A FI880788 A FI 880788A FI 880788 A FI880788 A FI 880788A FI 92353 B FI92353 B FI 92353B
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Finland
Prior art keywords
test
analyte
binder
flow
layer
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FI880788A
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English (en)
Finnish (fi)
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FI92353C (sv
FI880788A (sv
FI880788A0 (sv
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Edward Mcfarland
Keith Uithoven
Jeffrey Carlson
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Becton Dickinson Co
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56961—Plant cells or fungi
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/586—Liposomes, microcapsules or cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/824—Immunological separation techniques
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Holo Graphy (AREA)
  • Preparing Plates And Mask In Photomechanical Process (AREA)
  • Accessory Devices And Overall Control Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Maintenance And Management Of Digital Transmission (AREA)
  • Monitoring And Testing Of Exchanges (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • External Artificial Organs (AREA)

Claims (9)

1. Anordning (10) avsedd att användas vid bestim-ning av nirvaron av en anlyt genom att använda ett spir-5 imne, som har ett speciellt mirkimne i partikelform, kinnetecknad därav, att den omfattar: en porös bärare (11), som bestir av nitrocellulose, och vars porstorlek är 3 - 5 pm, och som har en Övre och en nedre yta samt ett testomride (18) pi sin Övre 10 yta; ett bindemedel sikert fist vid testomridet (18); ett absorberande lager (14) i flytande kontakt med den porösa biraren (11); samt ett strömningskontrollskikt (12), som ir en ej fi-15 beraktig, ensriktad, strömningskontrollerande membran, beligen mellan den nedre ytan hos den porösa biraren (11) och det absorberande skiktet (14); samt dirav, att porstorleken hos den porösa biraren (11) ir till-ricklig för att tillita passage av vitska och av den ej 20 specifikt till testomridet (18) bundna analyten och spir- imnet dirigenom, biraren (11) ej specifikt binder spirimnet, ytan hos testomridet (18) ir tillrickligt stor för att fista bindemedlet i en koncentration, vid vilken det 25 till testomridet (18) under testförhillandena specifikt bundna spirimnet ir synligt och porstorleken hos strömningskontrollskiktet (12) ir mindre in porstorleken hos den porösa biraren (11) och tillrickligt stor för att tillita passage av vitska och 30 till testomridet (18) ej specifikt bunden analyt och spirimne med kontrollerad hastighet, den porösa biraren (11) och det absorberande skiktet (14) fungerar tillsammans kontrollerande strömningen ., av reagenser genom den porösa biraren (11) och för att fi 35 vitskorna och den till testomridet (18) ej specifikt t II 92353 33 bundna analyten och spärämnet till det absorberande skik-tet (14).
2. Anordning (10) enligt patentkrav 1, känne-t e c k n a d därav, att den dessutom innehäller ett po-5 röst mellanskikt (13) beläget mellan strömningskontroll-skiktet (12) och det absorberande skiktet (14) och som tilläter vätska och till testomrädet (18) ej specifikt bunden analyt och spärämne att strömma frän testomrädet (18) till det absorberande omrädet.
3. Anordning (10) enligt patentkrav 1, känne- t e c k n a d därav, att bindemedlet är säkert fäst vid testomrädet (18) i en koncentration pä ätminstone 10 mik-rogram per cm2; och bäraren, strömningskontrollskiktet (12) och det absorberande skiktet (14) tilläter reagen- 15 serna att strömma genom testomrädet (18) under bestäm-ningsförhällandena.
4. Testförpackning, kännetecknad därav, att den innehäller en anordning (10) enligt patentkrav 1, och ett spärämne, som har ett speciellt märkämne 20. partikelform som är synligt dä spärämnet är bundet tili testomrädet (18) under testförhällandena.
5. Testförpackning enligt patentkrav 4, kännetecknad därav, att spärämnet är ett specifikt bin-dande ämne tili vilket är kopplat ett i partikelform va- 25 rande märkämne och det i partikelform varande märkämnet är en päse innehällande ett färgat ämne.
6. Testförpackning enligt patentkrav 5, känne- . t e c k n a d därav, att det i partikelform varande mär- '· kämnet är en liposom och det färgade ämnet är sulforod- 30 amin B.
7. Bestämningsmetod för en analyt i ett vätskefor-migt prov, kännetecknad därav, att tillgänglig är en anordning (10) enligt patentkrav 1 eller 4, • · r 35 man bringar tetsomrädet (18) hos anordningen (10) i kontakt med det vätskeformiga provet och spärämnet, som 34 92353 har ett speciellt märkämne i partikelform, som är synligt dä spärämnet är bundet till testomrädet (18) under test-förhällandena sälunda att den ej specifikt till testomrä-det bundna analyten och spärämnet strömmar frän testomrä-5 det (18) till det absorberande skiktet (14) samt man bestämmer visibiliteten hos det specifikt tili testomrädet (18) bundna spärämnet som ett mätt pä analyten.
8. Bestämningsmetod enligt patentkrav 7, k ä n -10 netecknad därav, att analyten utgör en del av det specifikt bindande paret, bindemedlet den andra delen av det specifikt bindande paret, och spärämnet bindes specifikt tili analyten i sädana punkter som ej stör den specifika bindningsreaktionen mellan analyt och bindeme-15 del.
9. Bestämningsmetod enligt patentkrav 8, k ä n -netecknad därav, att bäde analyten och spärämnet bindes specifikt tili bindemedlet och tävlar om de växelverkande bindande punkterna. » * » i < λ II
FI880788A 1987-02-20 1988-02-19 Förfarande, testanordning och testförpackning för snabb bestämning med synbar utläsning FI92353C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1684687A 1987-02-20 1987-02-20
US1684687 1987-02-20
US07/106,757 US4920046A (en) 1987-02-20 1987-10-08 Process, test device, and test kit for a rapid assay having a visible readout
US10675787 1987-10-08

Publications (4)

Publication Number Publication Date
FI880788A0 FI880788A0 (sv) 1988-02-19
FI880788A FI880788A (sv) 1988-08-21
FI92353B true FI92353B (sv) 1994-07-15
FI92353C FI92353C (sv) 1994-10-25

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FI880788A FI92353C (sv) 1987-02-20 1988-02-19 Förfarande, testanordning och testförpackning för snabb bestämning med synbar utläsning

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US (1) US4920046A (sv)
EP (1) EP0310862B1 (sv)
JP (1) JP2601498B2 (sv)
AT (1) ATE88570T1 (sv)
AU (1) AU1172088A (sv)
CA (1) CA1285870C (sv)
DE (1) DE3880415T2 (sv)
DK (1) DK87688A (sv)
ES (1) ES2054756T3 (sv)
FI (1) FI92353C (sv)
MY (1) MY103175A (sv)

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DE3880415D1 (de) 1993-05-27
EP0310862A3 (en) 1989-07-26
FI92353C (sv) 1994-10-25
US4920046A (en) 1990-04-24
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EP0310862A2 (en) 1989-04-12
JPH01124768A (ja) 1989-05-17
FI880788A (sv) 1988-08-21
DK87688D0 (da) 1988-02-19
ATE88570T1 (de) 1993-05-15
CA1285870C (en) 1991-07-09
MY103175A (en) 1993-04-30
AU1172088A (en) 1988-08-25
FI880788A0 (sv) 1988-02-19
DK87688A (da) 1988-08-21
EP0310862B1 (en) 1993-04-21
JP2601498B2 (ja) 1997-04-16
ES2054756T3 (es) 1994-08-16

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