FI920217L - Angiotensin ii receptor blockerande 2,3,6-substituerade kinazolinoner. - Google Patents

Angiotensin ii receptor blockerande 2,3,6-substituerade kinazolinoner. Download PDF

Info

Publication number
FI920217L
FI920217L FI920217A FI920217A FI920217L FI 920217 L FI920217 L FI 920217L FI 920217 A FI920217 A FI 920217A FI 920217 A FI920217 A FI 920217A FI 920217 L FI920217 L FI 920217L
Authority
FI
Finland
Prior art keywords
kinazolinoner
blockerande
substituerade
angiotensin
receptor
Prior art date
Application number
FI920217A
Other languages
English (en)
Finnish (fi)
Other versions
FI920217A7 (fi
FI920217A0 (fi
Inventor
Aranapakam M Venkatesan
Jeremy I Levin
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FI920217A0 publication Critical patent/FI920217A0/fi
Publication of FI920217A7 publication Critical patent/FI920217A7/fi
Publication of FI920217L publication Critical patent/FI920217L/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
    • C07D239/91Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Fats And Perfumes (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
FI920217A 1991-01-30 1992-01-17 Angiotensin ii receptor blockerande 2,3,6-substituerade kinazolinoner. FI920217L (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64849291A 1991-01-30 1991-01-30

Publications (3)

Publication Number Publication Date
FI920217A0 FI920217A0 (fi) 1992-01-17
FI920217A7 FI920217A7 (fi) 1992-07-31
FI920217L true FI920217L (fi) 1992-07-31

Family

ID=24601009

Family Applications (1)

Application Number Title Priority Date Filing Date
FI920217A FI920217L (fi) 1991-01-30 1992-01-17 Angiotensin ii receptor blockerande 2,3,6-substituerade kinazolinoner.

Country Status (23)

Country Link
US (2) US5290780A (cs)
EP (1) EP0497150B1 (cs)
JP (1) JP2758766B2 (cs)
KR (1) KR920014805A (cs)
CN (1) CN1037440C (cs)
AT (1) ATE164158T1 (cs)
AU (2) AU642573B2 (cs)
CA (1) CA2060154A1 (cs)
CZ (1) CZ281429B6 (cs)
DE (1) DE69224763T2 (cs)
DK (1) DK0497150T3 (cs)
ES (1) ES2117014T3 (cs)
FI (1) FI920217L (cs)
GR (1) GR3026592T3 (cs)
HU (1) HUT61748A (cs)
IE (1) IE920142A1 (cs)
IL (1) IL100711A0 (cs)
NO (1) NO920298L (cs)
NZ (1) NZ241343A (cs)
PL (1) PL293316A1 (cs)
SK (1) SK279004B6 (cs)
TW (1) TW282467B (cs)
ZA (1) ZA92392B (cs)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5290780A (en) * 1991-01-30 1994-03-01 American Cyanamid Co. Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
US5385894A (en) * 1991-03-06 1995-01-31 Merck & Co., Inc. Disubstituted 6-aminoquinazolinones
ES2126061T3 (es) * 1993-03-24 1999-03-16 American Home Prod Piridopirimidinas substituidas como antihipertensores.
US5358951A (en) * 1993-04-23 1994-10-25 American Cyanamid Company Angiotensin II receptor blocking 2, 3, 6 substituted quinazolinones
US5610301A (en) * 1993-07-01 1997-03-11 American Cyanamid Company Process for the regioselective n-alkylation of quinazolinones
US5342944A (en) * 1993-07-19 1994-08-30 American Cyanamid Company Process for the preparation of 2-alkyl-3,5,6,7- or 8-substituted-4(3H)-quinazolinones
US5338736A (en) * 1993-10-07 1994-08-16 American Cyanamid Company Angiotensin II receptor blocking 2,3,6-substituted quinazolinones
DK0782996T3 (da) * 1994-09-20 1999-09-20 Wakunaga Seiyaku Kk Fremgangsmåde til fremstilling af N-biphenylmethylthiadiazolinderivat eller salt deraf og mellemprodukt til fremstilling af
WO1996040684A1 (en) * 1995-06-07 1996-12-19 American Home Products Corporation Process for preparation of biphenyl derivatives
US5760220A (en) * 1995-06-07 1998-06-02 American Home Products Corporation Process for preparation of biphenyl derivatives
US5739330A (en) * 1996-02-05 1998-04-14 Hoechst Celanese Corporation Process for preparing quinazolones
US5763608A (en) * 1996-02-05 1998-06-09 Hoechst Celanese Corporation Process for preparing pyrimidine derivatives
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
GB0223730D0 (en) * 2002-10-11 2002-11-20 Novartis Ag Organic compounds
AU2003269360A1 (en) * 2002-10-18 2004-05-04 Koninklijke Philips Electronics N.V. Method and system for metadata protection in tv-anytime
AU2003291761A1 (en) * 2002-11-04 2004-06-07 Nps Pharmaceuticals, Inc. Quinazolinone compounds as calcilytics
GB0412769D0 (en) * 2004-06-08 2004-07-07 Novartis Ag Organic compounds
KR101129868B1 (ko) * 2006-10-04 2012-04-12 화이자 프로덕츠 인코포레이티드 칼슘 수용체 길항제로서의 피리도[4,3-d]피리미딘-4(3H)-온 유도체
CN103601792B (zh) 2007-06-04 2016-06-29 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
RS55717B1 (sr) 2012-06-13 2017-07-31 Hoffmann La Roche Novi diazaspirocikloalkan i azaspirocikloalkan
SI2900669T1 (sl) 2012-09-25 2019-12-31 F. Hoffmann-La Roche Ag Derivati heksahidropirolo(3,4-C)pirola in sorodne spojine kot zaviralci avtotaksina (ATX) in kot zaviralci tvorbe lizofosfatidne kisline (LPA) za zdravljenje npr. bolezni ledvic
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2913737A1 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
CN105764905B (zh) 2013-11-26 2019-06-07 豪夫迈·罗氏有限公司 新的八氢-环丁二烯并[1,2-c;3,4-c’]二吡咯-2基
EP3122751B1 (en) 2014-03-26 2019-10-30 F.Hoffmann-La Roche Ag Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
RS59477B1 (sr) 2014-03-26 2019-12-31 Hoffmann La Roche Biciklička jedinjenja kao inhibitori proizvodnje autotaksina (atx) i lizofosfatidne kiseline (lpa)
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
MX377277B (es) 2015-09-04 2025-03-07 Hoffmann La Roche Derivados de fenoximetilo.
CR20180057A (es) 2015-09-24 2018-04-02 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de atx/ca.
CN115124538A (zh) 2015-09-24 2022-09-30 豪夫迈·罗氏有限公司 作为atx抑制剂的二环化合物
WO2017050792A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag Bicyclic compounds as atx inhibitors
MX2017015034A (es) 2015-09-24 2018-04-13 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca).
MA49879A (fr) 2017-03-16 2020-06-24 Hoffmann La Roche Composés hétérocycliques utiles en tant qu'inhibiteurs doubles d'atx/ca
CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
CN107056715B (zh) * 2017-04-07 2019-07-30 江南大学 一种增强TRPV4-KCa2.3复合体耦联度的化合物及其在抗高血压中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607683D0 (en) * 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
WO1988001270A1 (en) * 1986-08-21 1988-02-25 Pfizer Inc. Pyridopyrimidinediones
CS272018B1 (en) * 1988-11-01 1990-12-13 Fisnerova Ludmila Ethereal derivatives of 4/3h/-quinazolinone
US5240928A (en) * 1989-07-03 1993-08-31 Merck & Co., Inc. Substituted quinazolinones as angiotensin II antagonists
CA2020073A1 (en) * 1989-07-03 1991-01-04 Eric E. Allen Substituted quinazolinones as angiotensin ii antagonists
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
CA2037630C (en) * 1990-03-07 2001-07-03 Akira Morimoto Nitrogen-containing heterocylic compounds, their production and use
CA2053148A1 (en) * 1990-10-16 1992-04-17 Karnail Atwal Dihydropyrimidine derivatives
US5290780A (en) * 1991-01-30 1994-03-01 American Cyanamid Co. Angiotensin II receptor blocking 2,3,6 substituted quinazolinones

Also Published As

Publication number Publication date
JP2758766B2 (ja) 1998-05-28
ES2117014T3 (es) 1998-08-01
HU9200278D0 (en) 1992-04-28
HUT61748A (en) 1993-03-01
FI920217A7 (fi) 1992-07-31
NZ241343A (en) 1994-06-27
DE69224763T2 (de) 1998-07-09
EP0497150B1 (en) 1998-03-18
US5290780A (en) 1994-03-01
IE920142A1 (en) 1992-07-29
AU647992B2 (en) 1994-03-31
IL100711A0 (en) 1992-09-06
CZ281429B6 (cs) 1996-09-11
ZA92392B (en) 1992-10-28
JPH0578332A (ja) 1993-03-30
SK279004B6 (sk) 1998-05-06
CS25592A3 (en) 1992-08-12
ATE164158T1 (de) 1998-04-15
AU1039792A (en) 1992-08-06
DE69224763D1 (de) 1998-04-23
NO920298D0 (no) 1992-01-22
CN1037440C (zh) 1998-02-18
DK0497150T3 (da) 1998-06-02
FI920217A0 (fi) 1992-01-17
KR920014805A (ko) 1992-08-25
TW282467B (cs) 1996-08-01
NO920298L (no) 1992-07-31
CN1066847A (zh) 1992-12-09
AU642573B2 (en) 1993-10-21
US5405849A (en) 1995-04-11
AU4490693A (en) 1993-11-18
PL293316A1 (en) 1993-08-23
EP0497150A1 (en) 1992-08-05
CA2060154A1 (en) 1992-07-31
GR3026592T3 (en) 1998-07-31

Similar Documents

Publication Publication Date Title
FI920217L (fi) Angiotensin ii receptor blockerande 2,3,6-substituerade kinazolinoner.
FI921708A0 (fi) Stolstoppning, speciellt flygplans- faotoelj.
FI922494A0 (fi) Pulverformig, enzymer innehaollande diskmedelskomposition foer automatiska diskmaskiner.
FI923072A0 (fi) Maongstegsbindemedel foer anvaendning i elastomerbelaeggningar, mastixbelaeggningar, dikt- och taetningsmedel.
SV1996000005A (es) Quinazolinonas bisustituidas en 2,8
FI916165A0 (fi) 1,3-oxatiolannukleosidanaloger.
FI925721L (fi) Transportabel medicinsk anordning, saerskild infusionsbehandlingsapparat
FI922493L (fi) Vattenfri, flytande, enzymer innehaollande diskmedelskomposition foer automatiska diskmaskiner
DE69203428D1 (de) Verbinder.
FI935497A0 (fi) Saekerhetsventil foer hoegtryckspumpar, hoegtryckvattenstraolemaskiner e.d.
FI922451L (fi) Vaermehaerdande, pulveraktig belaeggningskomposition
FI922487L (fi) Foerbaettrad vattenfri, flytande, fosfatfri, enzymer innehaollande diskmedelskomposition foer automatiska diskmaskiner
TR27961A (tr) Sübstitüe edilmis 1,2,3,4 -tetrahidro-5-nitro-pirimidinler.
DE69203171D1 (de) Verbinder.
FI923189L (fi) 2-substituerade 4,5-difenylimidatsoler.
DE69204920D1 (de) Angiotensin-II-Antagoniste.
FI922654A0 (fi) Saekringsanordning foer avtryckar- mekanismer, isynnerhet foer eldvapen.
FI910640L (fi) Foerfarande foer minskning av fosfor- och tungmetallbelastningen i vattendrag, vilken belastning foerorsakats av odlingsmarker.
ES1016723Y (es) Boligrafo-pulverizador mejorado.
FI925411A0 (fi) Fartyg, speciellt handelsfartyg
FI921759A0 (fi) Lineaer viskoelastisk vattenhaltig flytande detergentkomposition, speciellt foer automatiska diskmaskiner.
FI924307A0 (fi) Regionselektiv syntes av antiinflammatoriska 1,5-diarylpyrazollaekemedel.
DE69203364D1 (de) Verbinder.
FI923542A0 (fi) Faestanordning foer klingor, isynnerhet i bestrykningsmaskiner.
TR26505A (tr) Fenil ikameli 4,5- dihidropirazoller