FI920217L - Angiotensin ii receptor blockerande 2,3,6-substituerade kinazolinoner. - Google Patents
Angiotensin ii receptor blockerande 2,3,6-substituerade kinazolinoner. Download PDFInfo
- Publication number
- FI920217L FI920217L FI920217A FI920217A FI920217L FI 920217 L FI920217 L FI 920217L FI 920217 A FI920217 A FI 920217A FI 920217 A FI920217 A FI 920217A FI 920217 L FI920217 L FI 920217L
- Authority
- FI
- Finland
- Prior art keywords
- kinazolinoner
- blockerande
- substituerade
- angiotensin
- receptor
- Prior art date
Links
- 102000008873 Angiotensin II receptor Human genes 0.000 title 1
- 108050000824 Angiotensin II receptor Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fats And Perfumes (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Manufacture Of Tobacco Products (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64849291A | 1991-01-30 | 1991-01-30 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI920217A0 FI920217A0 (fi) | 1992-01-17 |
| FI920217A7 FI920217A7 (fi) | 1992-07-31 |
| FI920217L true FI920217L (fi) | 1992-07-31 |
Family
ID=24601009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI920217A FI920217L (fi) | 1991-01-30 | 1992-01-17 | Angiotensin ii receptor blockerande 2,3,6-substituerade kinazolinoner. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US5290780A (cs) |
| EP (1) | EP0497150B1 (cs) |
| JP (1) | JP2758766B2 (cs) |
| KR (1) | KR920014805A (cs) |
| CN (1) | CN1037440C (cs) |
| AT (1) | ATE164158T1 (cs) |
| AU (2) | AU642573B2 (cs) |
| CA (1) | CA2060154A1 (cs) |
| CZ (1) | CZ281429B6 (cs) |
| DE (1) | DE69224763T2 (cs) |
| DK (1) | DK0497150T3 (cs) |
| ES (1) | ES2117014T3 (cs) |
| FI (1) | FI920217L (cs) |
| GR (1) | GR3026592T3 (cs) |
| HU (1) | HUT61748A (cs) |
| IE (1) | IE920142A1 (cs) |
| IL (1) | IL100711A0 (cs) |
| NO (1) | NO920298L (cs) |
| NZ (1) | NZ241343A (cs) |
| PL (1) | PL293316A1 (cs) |
| SK (1) | SK279004B6 (cs) |
| TW (1) | TW282467B (cs) |
| ZA (1) | ZA92392B (cs) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5290780A (en) * | 1991-01-30 | 1994-03-01 | American Cyanamid Co. | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones |
| US5385894A (en) * | 1991-03-06 | 1995-01-31 | Merck & Co., Inc. | Disubstituted 6-aminoquinazolinones |
| DE69415706T2 (de) * | 1993-03-24 | 1999-05-20 | American Home Products Corp., Madison, N.J. | Substituierte Pyridopyrimidine als Antihypertensiva |
| US5358951A (en) * | 1993-04-23 | 1994-10-25 | American Cyanamid Company | Angiotensin II receptor blocking 2, 3, 6 substituted quinazolinones |
| US5610301A (en) * | 1993-07-01 | 1997-03-11 | American Cyanamid Company | Process for the regioselective n-alkylation of quinazolinones |
| US5342944A (en) * | 1993-07-19 | 1994-08-30 | American Cyanamid Company | Process for the preparation of 2-alkyl-3,5,6,7- or 8-substituted-4(3H)-quinazolinones |
| US5338736A (en) * | 1993-10-07 | 1994-08-16 | American Cyanamid Company | Angiotensin II receptor blocking 2,3,6-substituted quinazolinones |
| DE69507887T2 (de) * | 1994-09-20 | 1999-06-17 | Wakunaga Seiyaku K.K., Osaka | Verfahren zur herstellung von n-biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen |
| US5760220A (en) * | 1995-06-07 | 1998-06-02 | American Home Products Corporation | Process for preparation of biphenyl derivatives |
| NZ310164A (en) * | 1995-06-07 | 2000-01-28 | American Home Prod | Process for preparation of 8-[2'-(2(1)-tert-butyl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,4-dimethyl-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one derivatives |
| US5763608A (en) * | 1996-02-05 | 1998-06-09 | Hoechst Celanese Corporation | Process for preparing pyrimidine derivatives |
| US5739330A (en) * | 1996-02-05 | 1998-04-14 | Hoechst Celanese Corporation | Process for preparing quinazolones |
| US6638937B2 (en) | 1998-07-06 | 2003-10-28 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| GB0223730D0 (en) * | 2002-10-11 | 2002-11-20 | Novartis Ag | Organic compounds |
| CN1706169A (zh) * | 2002-10-18 | 2005-12-07 | 皇家飞利浦电子股份有限公司 | 用于即时电视中的元数据保护的方法、系统、装置、信号和计算机程序产品 |
| JP2006512315A (ja) * | 2002-11-04 | 2006-04-13 | エヌピーエス ファーマスーティカルズ インコーポレイテッド | カルシリティックとしてのキナゾリノン化合物 |
| GB0412769D0 (en) * | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
| EP2079739A2 (en) * | 2006-10-04 | 2009-07-22 | Pfizer Products Inc. | Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists |
| AU2008261102B2 (en) | 2007-06-04 | 2013-11-28 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8034782B2 (en) | 2008-07-16 | 2011-10-11 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CA2930674A1 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| BR112014030473A2 (pt) | 2012-06-13 | 2017-06-27 | Hoffmann La Roche | novo diazaespirocicloalcano e azaespirocicloalcano |
| SG11201500572YA (en) | 2012-09-25 | 2015-02-27 | Hoffmann La Roche | New bicyclic derivatives |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| AU2014235215A1 (en) | 2013-03-15 | 2015-10-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| EP2968439A2 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| CN113388007A (zh) | 2013-06-05 | 2021-09-14 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
| EA201691044A1 (ru) | 2013-11-26 | 2016-09-30 | Ф. Хоффманн-Ля Рош Аг | Новый октагидро-циклобута[1,2-c;3,4-c']дипиррол-2-ил |
| CN110204550B (zh) | 2014-03-26 | 2022-05-17 | 豪夫迈·罗氏有限公司 | 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的二环化合物 |
| MX373236B (es) | 2014-03-26 | 2020-05-08 | Hoffmann La Roche | Compuestos condensados de [1,4]diazepina como inhibidores de producción de la autotaxina (atx) y ácido lisofosfatidico (lpa). |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| CN108026077B (zh) | 2015-09-04 | 2021-11-05 | 豪夫迈·罗氏有限公司 | 苯氧基甲基衍生物 |
| CN107635995B (zh) | 2015-09-24 | 2022-08-19 | 豪夫迈·罗氏有限公司 | 作为atx抑制剂的二环化合物 |
| CR20180072A (es) | 2015-09-24 | 2018-02-26 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores de atx |
| RU2725138C2 (ru) | 2015-09-24 | 2020-06-30 | Ф. Хоффманн-Ля Рош Аг | Новые бициклические соединения в качестве двойных ингибиторов аутотаксина (atx)/карбоангидразы (ca) |
| CA2991612A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual atx/ca inhibitors |
| WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
| CN110392679B (zh) | 2017-03-16 | 2023-04-07 | 豪夫迈·罗氏有限公司 | 可用作双重atx/ca抑制剂的杂环化合物 |
| CN107056715B (zh) * | 2017-04-07 | 2019-07-30 | 江南大学 | 一种增强TRPV4-KCa2.3复合体耦联度的化合物及其在抗高血压中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607683D0 (en) * | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
| PH23853A (en) * | 1986-08-21 | 1989-11-23 | Pfizer | Pyridopyrimidinediones |
| CS272018B1 (en) * | 1988-11-01 | 1990-12-13 | Fisnerova Ludmila | Ethereal derivatives of 4/3h/-quinazolinone |
| CA2020073A1 (en) * | 1989-07-03 | 1991-01-04 | Eric E. Allen | Substituted quinazolinones as angiotensin ii antagonists |
| US5240928A (en) * | 1989-07-03 | 1993-08-31 | Merck & Co., Inc. | Substituted quinazolinones as angiotensin II antagonists |
| EP0407342A3 (en) * | 1989-07-06 | 1991-07-10 | Ciba-Geigy Ag | Pyrimidine derivatives |
| CA2037630C (en) * | 1990-03-07 | 2001-07-03 | Akira Morimoto | Nitrogen-containing heterocylic compounds, their production and use |
| CA2053148A1 (en) * | 1990-10-16 | 1992-04-17 | Karnail Atwal | Dihydropyrimidine derivatives |
| US5290780A (en) * | 1991-01-30 | 1994-03-01 | American Cyanamid Co. | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones |
-
1992
- 1992-01-14 US US07/818,721 patent/US5290780A/en not_active Expired - Lifetime
- 1992-01-16 EP EP92100640A patent/EP0497150B1/en not_active Expired - Lifetime
- 1992-01-16 DK DK92100640.9T patent/DK0497150T3/da active
- 1992-01-16 AT AT92100640T patent/ATE164158T1/de not_active IP Right Cessation
- 1992-01-16 ES ES92100640T patent/ES2117014T3/es not_active Expired - Lifetime
- 1992-01-16 DE DE69224763T patent/DE69224763T2/de not_active Expired - Fee Related
- 1992-01-17 IE IE014292A patent/IE920142A1/en not_active Application Discontinuation
- 1992-01-17 FI FI920217A patent/FI920217L/fi unknown
- 1992-01-20 IL IL100711A patent/IL100711A0/xx unknown
- 1992-01-20 ZA ZA92392A patent/ZA92392B/xx unknown
- 1992-01-21 NZ NZ241343A patent/NZ241343A/en unknown
- 1992-01-22 AU AU10397/92A patent/AU642573B2/en not_active Ceased
- 1992-01-22 NO NO92920298A patent/NO920298L/no unknown
- 1992-01-28 CA CA002060154A patent/CA2060154A1/en not_active Abandoned
- 1992-01-29 PL PL29331692A patent/PL293316A1/xx unknown
- 1992-01-29 JP JP4038746A patent/JP2758766B2/ja not_active Expired - Lifetime
- 1992-01-29 CZ CS92255A patent/CZ281429B6/cs unknown
- 1992-01-29 SK SK255-92A patent/SK279004B6/sk unknown
- 1992-01-30 CN CN92100545A patent/CN1037440C/zh not_active Expired - Fee Related
- 1992-01-30 KR KR1019920001413A patent/KR920014805A/ko not_active Ceased
- 1992-01-30 HU HU9200278A patent/HUT61748A/hu unknown
- 1992-01-31 TW TW081100762A patent/TW282467B/zh active
-
1993
- 1993-08-25 AU AU44906/93A patent/AU647992B2/en not_active Ceased
- 1993-10-29 US US08/145,458 patent/US5405849A/en not_active Expired - Lifetime
-
1998
- 1998-04-10 GR GR980400781T patent/GR3026592T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2060154A1 (en) | 1992-07-31 |
| GR3026592T3 (en) | 1998-07-31 |
| CZ281429B6 (cs) | 1996-09-11 |
| IE920142A1 (en) | 1992-07-29 |
| FI920217A7 (fi) | 1992-07-31 |
| NO920298D0 (no) | 1992-01-22 |
| KR920014805A (ko) | 1992-08-25 |
| PL293316A1 (en) | 1993-08-23 |
| FI920217A0 (fi) | 1992-01-17 |
| SK279004B6 (sk) | 1998-05-06 |
| JPH0578332A (ja) | 1993-03-30 |
| EP0497150A1 (en) | 1992-08-05 |
| NZ241343A (en) | 1994-06-27 |
| TW282467B (cs) | 1996-08-01 |
| NO920298L (no) | 1992-07-31 |
| AU647992B2 (en) | 1994-03-31 |
| US5405849A (en) | 1995-04-11 |
| AU1039792A (en) | 1992-08-06 |
| HUT61748A (en) | 1993-03-01 |
| DE69224763T2 (de) | 1998-07-09 |
| DK0497150T3 (da) | 1998-06-02 |
| IL100711A0 (en) | 1992-09-06 |
| ATE164158T1 (de) | 1998-04-15 |
| ZA92392B (en) | 1992-10-28 |
| ES2117014T3 (es) | 1998-08-01 |
| CN1037440C (zh) | 1998-02-18 |
| HU9200278D0 (en) | 1992-04-28 |
| CS25592A3 (en) | 1992-08-12 |
| JP2758766B2 (ja) | 1998-05-28 |
| AU4490693A (en) | 1993-11-18 |
| AU642573B2 (en) | 1993-10-21 |
| EP0497150B1 (en) | 1998-03-18 |
| CN1066847A (zh) | 1992-12-09 |
| DE69224763D1 (de) | 1998-04-23 |
| US5290780A (en) | 1994-03-01 |
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