FI90343B - Förfarande för framställning av antihypertoniska och antiarytmiska trans-2,2-dimetylkroman-3-olderivat - Google Patents

Förfarande för framställning av antihypertoniska och antiarytmiska trans-2,2-dimetylkroman-3-olderivat Download PDF

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Publication number
FI90343B
FI90343B FI882945A FI882945A FI90343B FI 90343 B FI90343 B FI 90343B FI 882945 A FI882945 A FI 882945A FI 882945 A FI882945 A FI 882945A FI 90343 B FI90343 B FI 90343B
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FI
Finland
Prior art keywords
trans
group
cyano
formula
mixture
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Application number
FI882945A
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English (en)
Finnish (fi)
Other versions
FI90343C (sv
FI882945A (sv
FI882945A0 (sv
Inventor
Patrick Gautier
Georges Garcia
Richard Roux
Dino Nisato
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8708830A external-priority patent/FR2617165B1/fr
Priority claimed from FR8800278A external-priority patent/FR2625744B1/fr
Priority claimed from FR8803064A external-priority patent/FR2628424B1/fr
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of FI882945A0 publication Critical patent/FI882945A0/sv
Publication of FI882945A publication Critical patent/FI882945A/sv
Publication of FI90343B publication Critical patent/FI90343B/sv
Application granted granted Critical
Publication of FI90343C publication Critical patent/FI90343C/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10L—FUELS NOT OTHERWISE PROVIDED FOR; NATURAL GAS; SYNTHETIC NATURAL GAS OBTAINED BY PROCESSES NOT COVERED BY SUBCLASSES C10G, C10K; LIQUEFIED PETROLEUM GAS; ADDING MATERIALS TO FUELS OR FIRES TO REDUCE SMOKE OR UNDESIRABLE DEPOSITS OR TO FACILITATE SOOT REMOVAL; FIRELIGHTERS
    • C10L1/00—Liquid carbonaceous fuels
    • C10L1/32—Liquid carbonaceous fuels consisting of coal-oil suspensions or aqueous emulsions or oil emulsions

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Claims (6)

1. Förfarande för framställning av antihypertonis- > ka och antiarytmiska trans-2,2-dimetylkroman-3-olderivat 5 med formeIn VN/J z . 1 .OH· m, \ΛΛ; 15. vilken A mellan N och CO är gruppen -CH=CH-E=CH- eller gruppen -n=C-C=C-; I I I R1R2R3
20 Z är en halogen- eller cyan-, acetyl-, trifluorace- tyl-, nitro-, alkyltio- eller dialkoxifosforylgrupp, var-vid alkyltio- och alkoxigrupperna innehäller 1-3 kolato-mer ; E är en kväveatom eller gruppen C(R4);
25 Rt är en väteatom eller en metyl- eller hydroxyl- grupp och R2 och R3 är väteatomer eller metylgrupper, varvid endast en av substituenterna R1; R2 och R3 är metyl; och R4 är en väte- eller halogenatom eller en metyl-30 eller hydroxylgrupp, kännetecknat därav, att * en kromanepoxid med formeln 35 \ΛοΛ“3 34 n 7 A 7 - 'j sj I o i vilken Z är ovan definierad, behandlas med en heterocyk-lisk förening med den ena av tautomeriska former 5 f \ ---> ( C (III) \A„ <— H i vilken A är ovan definierad. 10
2. Förfarande enligt patentkravet 1, kanne- t e c k n a t därav, att behandlingen utförs vid en tem-peratur av 10 - 100 °C i ett inert organiskt lösningsmedel i närvaro av ett basiskt kondensationsmedel.
3. Förfarande enligt patentkravet 1 eller 2, 15 kännetecknat därav, att en epoxid med formeln II, i vilken Z är en cyangrupp, behandlas.
4. Förfarande enligt nägot av patentkraven 1-3, kännetecknat därav, att föreningen enligt formeln III är 2-hydroxipyridin och den erhällna föreningen 20 är trans-6-cyan-4-(l,2-dihydro-2-oxopyrid-l-yl)-2,2-dime- tylkroman-3-ol.
5. Förfarande enligt nägot av patentkraven 1-3, kännetecknat därav, att föreningen enligt formeln III är 2,4—dihydroxipyridin och den erhällna förenin- 25 gen är trans-6-cyan-4-(1,2-dihydro-4-hydroxi-2-oxopyrid-l- yl)-2,2-dimetylkroman-3-ol.
6. Förfarande enligt nägot av patentkraven 1-3, kännetecknat därav, att föreningen enligt formeln III är 3,6—dihydroxipyridazin och den erhällna för- 30 eningen är trans-6-cyan-4-(l,6-dihydro-3-hydroxi-6-oxo- kpyridazin-l-yl)-2,2-dimetyl-5-kroman-3-ol.
FI882945A 1987-06-23 1988-06-20 Förfarande för framställning av antihypertoniska och antiarytmiska trans-2,2-dimetylkroman-3-olderivat FI90343C (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
FR8708830A FR2617165B1 (fr) 1987-06-23 1987-06-23 Derives du dimethyl-2, 2 chromannol-3
FR8708830 1987-06-23
FR8800278 1988-01-12
FR8800278A FR2625744B1 (fr) 1988-01-12 1988-01-12 Derives du dimethyl-2,2 chromannol-3 procede d'obtention et compositions pharmaceutiques en contenant
FR8803064A FR2628424B1 (fr) 1988-03-09 1988-03-09 Derives du dimethyl-2,2 chromannol-3 procede d'obtention et compositions pharmaceutiques en contenant
FR8803064 1988-03-09

Publications (4)

Publication Number Publication Date
FI882945A0 FI882945A0 (sv) 1988-06-20
FI882945A FI882945A (sv) 1988-12-24
FI90343B true FI90343B (sv) 1993-10-15
FI90343C FI90343C (sv) 1994-01-25

Family

ID=27251476

Family Applications (1)

Application Number Title Priority Date Filing Date
FI882945A FI90343C (sv) 1987-06-23 1988-06-20 Förfarande för framställning av antihypertoniska och antiarytmiska trans-2,2-dimetylkroman-3-olderivat

Country Status (9)

Country Link
EP (1) EP0296975A1 (sv)
JP (1) JPS6426578A (sv)
KR (1) KR890000470A (sv)
DK (1) DK343388A (sv)
FI (1) FI90343C (sv)
IL (1) IL86798A (sv)
NO (1) NO170216C (sv)
NZ (1) NZ225117A (sv)
PT (1) PT87788B (sv)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3726261A1 (de) * 1986-12-23 1988-07-07 Merck Patent Gmbh Chromanderivate
US5387587A (en) * 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
US5284838A (en) * 1987-06-23 1994-02-08 Elf Sanofi Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma
US4971982A (en) * 1987-07-06 1990-11-20 Hoffmann-La Roche Inc. Benzopyran derivatives
US5021432A (en) * 1988-04-26 1991-06-04 Yoshitomi Pharmaceutical Industries, Ltd. Benzopyran compound and its pharmaceutical use
US5254557A (en) * 1988-05-09 1993-10-19 Beecham Group P.L.C. Compound and treatment
EP0373204A1 (en) * 1988-05-09 1990-06-20 Beecham Group Plc Novel compounds and treatment
DE3837809A1 (de) * 1988-11-08 1990-05-10 Merck Patent Gmbh Tetralinderivate
ES2071668T3 (es) * 1988-12-13 1995-07-01 Beecham Group Plc Benzopirano y compuestos relacionados.
GB8902118D0 (en) * 1989-02-01 1989-03-22 Beecham Group Plc Chemical process
US5239090A (en) * 1989-02-01 1993-08-24 Beecham Group P.L.C. Certain optically active 3,4-dihydrobenzopyran-4-ols which are intermediates
US5066816A (en) * 1989-03-03 1991-11-19 Yoshitomi Pharmaceutical Industries, Ltd. Processes for preparing optically active 3,4-dihydro-3,4-epoxy-2h-1-benzopyran compounds and intermediates therefor
US5162553A (en) * 1989-03-03 1992-11-10 Yoshitomi Pharmaceutical Industries, Ltd. Processes for preparing optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compounds and intermediates therefor
FR2645021A1 (fr) * 1989-03-30 1990-10-05 Sanofi Sa Utilisation d'un agoniste potassique dans le traitement du glaucome
DE3923839A1 (de) * 1989-07-19 1991-01-31 Beiersdorf Ag Benzopyran-derivate, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
GB8916683D0 (en) * 1989-07-21 1989-09-06 Beecham Group Plc Novel compounds
DE3924417A1 (de) * 1989-07-24 1991-01-31 Merck Patent Gmbh Chromanderivate
DE3926001A1 (de) * 1989-08-05 1991-02-07 Merck Patent Gmbh Chromanderivate
FR2657872B2 (fr) * 1989-11-06 1992-06-12 Sanofi Sa Derive d'amidino-4 chromanne, procede d'obtention et compositions pharmaceutiques le contenant.
FR2654103B1 (fr) * 1989-11-06 1992-02-21 Sanofi Sa Derives d'amidino-4 chromanne, procede d'obtention et compositions pharmaceutiques les contenant.
US5185345A (en) * 1989-11-06 1993-02-09 Sanofi 4-amidino pyrano (3,2-c) pyridine derivatives, and pharmaceutical compositions containing them
DE4115465A1 (de) * 1991-05-11 1992-11-12 Beiersdorf Ag Neue in 4-stellung durch aryl oder n-heteroaryl substituierte 2h-benzo(b)pyran-derivate, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
BR9206845A (pt) * 1991-12-05 1996-01-02 Smithkline Beecham Plc Composto famacêutico
GB9203596D0 (en) * 1992-02-20 1992-04-08 Smithkline Beecham Plc Novel process
GB9207400D0 (en) * 1992-04-02 1992-05-13 Smithkline Beecham Plc Novel use
ES2145129T3 (es) * 1992-08-17 2000-07-01 Chugai Pharmaceutical Co Ltd Derivados de benzopirano y benzoxazina.
US6031115A (en) * 1993-05-14 2000-02-29 Smithkline Beecham Plc Process for preparing epoxides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE23718T1 (de) * 1981-09-25 1986-12-15 Beecham Group Plc Benzopyran-verbindungen mit pharmazeutischer wirkung.
EP0107423B1 (en) * 1982-10-19 1986-07-23 Beecham Group Plc Novel chromans and chromenes
DE3579390D1 (de) * 1984-06-22 1990-10-04 Beecham Group Plc Wirksame benzopyranverbindungen.
DE3726261A1 (de) * 1986-12-23 1988-07-07 Merck Patent Gmbh Chromanderivate

Also Published As

Publication number Publication date
DK343388A (da) 1988-12-24
NO170216C (no) 1992-09-23
FI90343C (sv) 1994-01-25
DK343388D0 (da) 1988-06-22
NO170216B (no) 1992-06-15
FI882945A (sv) 1988-12-24
PT87788A (pt) 1988-07-01
EP0296975A1 (fr) 1988-12-28
NZ225117A (en) 1990-02-26
KR890000470A (ko) 1989-03-14
NO882762D0 (no) 1988-06-22
IL86798A0 (en) 1988-11-30
IL86798A (en) 1992-12-01
PT87788B (pt) 1992-10-30
FI882945A0 (sv) 1988-06-20
NO882762L (no) 1988-12-27
JPS6426578A (en) 1989-01-27

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