FI901148A0 - Tetrahydrokinolinderivat som aer anvaendbara vid vaord av neurodegenerativa stoerningar. - Google Patents

Tetrahydrokinolinderivat som aer anvaendbara vid vaord av neurodegenerativa stoerningar.

Info

Publication number
FI901148A0
FI901148A0 FI901148A FI901148A FI901148A0 FI 901148 A0 FI901148 A0 FI 901148A0 FI 901148 A FI901148 A FI 901148A FI 901148 A FI901148 A FI 901148A FI 901148 A0 FI901148 A0 FI 901148A0
Authority
FI
Finland
Prior art keywords
vaord
tetrahydrokinolinderivat
stoerningar
neurodegenerativa
som aer
Prior art date
Application number
FI901148A
Other languages
English (en)
Finnish (fi)
Inventor
Raymond Barker
William R Carling
Paul D Leeson
Julian D Smith
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898905334A external-priority patent/GB8905334D0/en
Priority claimed from GB898926431A external-priority patent/GB8926431D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of FI901148A0 publication Critical patent/FI901148A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other Liquid Machine Or Engine Such As Wave Power Use (AREA)
  • Hydrogenated Pyridines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
FI901148A 1989-03-08 1990-03-07 Tetrahydrokinolinderivat som aer anvaendbara vid vaord av neurodegenerativa stoerningar. FI901148A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898905334A GB8905334D0 (en) 1989-03-08 1989-03-08 Therapeutic agents
GB898926431A GB8926431D0 (en) 1989-11-22 1989-11-22 Therapeutic agents

Publications (1)

Publication Number Publication Date
FI901148A0 true FI901148A0 (fi) 1990-03-07

Family

ID=26295073

Family Applications (1)

Application Number Title Priority Date Filing Date
FI901148A FI901148A0 (fi) 1989-03-08 1990-03-07 Tetrahydrokinolinderivat som aer anvaendbara vid vaord av neurodegenerativa stoerningar.

Country Status (11)

Country Link
EP (1) EP0386839B1 (fr)
JP (1) JPH0334969A (fr)
KR (1) KR900014321A (fr)
AT (1) ATE147732T1 (fr)
AU (1) AU5114490A (fr)
CA (1) CA2011686A1 (fr)
DE (1) DE69029668T2 (fr)
FI (1) FI901148A0 (fr)
IL (1) IL93610A0 (fr)
NO (1) NO901082L (fr)
PT (1) PT93362A (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268378A (en) * 1990-05-31 1993-12-07 Merck Sharp & Dohme, Limited Dioxo-tetrahydroquinoline derivatives
US5401848A (en) * 1990-11-26 1995-03-28 E. R. Squibb & Sons, Inc. Indane and quinoline derivatives
EP0573562B1 (fr) * 1991-02-27 1996-04-24 Merrell Pharmaceuticals Inc. Dihydroquinoline antagonistes de NMDA
US5606063A (en) * 1991-02-27 1997-02-25 Merrell Pharmaceuticals Inc. NMDA antagonists
GB9109007D0 (en) * 1991-04-26 1991-06-12 Merck Sharp & Dohme Therapeutic method
FR2683818B1 (fr) * 1991-11-14 1993-12-31 Adir Cie Nouveaux derives de 3-sulfonylamino-2-(1h)-quinoleinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
GB9125515D0 (en) * 1991-11-29 1992-01-29 Merck Sharp & Dohme Therapeutic agents
CA2232509A1 (fr) * 1995-09-29 1997-04-10 Glaxo Wellcome Spa Tetrahydroquinolines utiles en tant qu'antagonistes du nmda (n-methyl-d-aspartate)
GB9617305D0 (en) * 1996-08-17 1996-09-25 Glaxo Wellcome Spa Heterocyclic compounds
DE19705133A1 (de) * 1997-02-11 1998-08-13 Hoechst Ag Sulfonamid-substituierte Verbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
GB9706294D0 (en) * 1997-03-26 1997-05-14 Glaxo Wellcome Spa Heterocyclic compound
MY125037A (en) * 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives
US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
EP1607389A1 (fr) * 1999-09-10 2005-12-21 Pfizer Products Inc. DERIVES 4-amino-1,2,3,4-tétrahydroquinoline N-protégés et 2-substitues, utiles comme intermédiaires pour des inhibiteurs CETP
DE10000311A1 (de) 2000-01-05 2001-07-12 Gruenenthal Gmbh Aminomethyl-Phonyl-Cyclohexanonderivate
DE10005302A1 (de) * 2000-02-07 2002-01-17 Gruenenthal Gmbh Substituierte 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate
CA2416454A1 (fr) * 2000-12-07 2003-01-14 Japan Science And Technology Corporation Intermediaires pour la synthese de vinblastine et ses congeneres, et procede pour la synthese de ces intermediaires
DE10132725A1 (de) 2001-07-05 2006-08-03 Grünenthal GmbH Substituierte γ-Lactonverbindungen
DE10137488A1 (de) * 2001-08-03 2003-02-20 Gruenenthal Gmbh Salze substituierter 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate
DE10137487A1 (de) 2001-08-03 2003-03-27 Gruenenthal Gmbh Substituierte 5,6,6a,11b-Tetrahydro-7-oxa-6-aza- benzo[c]fluoren-6-carbonsäurederivate
JP4932730B2 (ja) * 2004-11-24 2012-05-16 アボット・ラボラトリーズ バニロイド受容体サブタイプ１（ｖｒ１）受容体を阻害するクロマニル尿素化合物およびその使用
UY30244A1 (es) 2006-03-30 2007-11-30 Tanabe Seiyaku Co Un proceso para preparar derivados de tetrahidroquinolina
EP3427729A1 (fr) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probénécide destiné à être utilisé dans le traitement de maladies, troubles ou états épileptiques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH23848A (en) * 1985-05-24 1989-11-23 Ciba Geigy Ag Certain phosphonic acids and derivatives
GB8719102D0 (en) * 1987-08-12 1987-09-16 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
EP0386839A3 (fr) 1991-10-23
DE69029668T2 (de) 1997-08-07
JPH0334969A (ja) 1991-02-14
ATE147732T1 (de) 1997-02-15
NO901082D0 (no) 1990-03-07
CA2011686A1 (fr) 1990-09-08
IL93610A0 (en) 1990-12-23
EP0386839B1 (fr) 1997-01-15
PT93362A (pt) 1990-11-07
DE69029668D1 (de) 1997-02-27
KR900014321A (ko) 1990-10-23
EP0386839A2 (fr) 1990-09-12
AU5114490A (en) 1990-09-13
NO901082L (no) 1990-09-10

Similar Documents

Publication Publication Date Title
FI901148A0 (fi) Tetrahydrokinolinderivat som aer anvaendbara vid vaord av neurodegenerativa stoerningar.
DE3850676D1 (de) Hypotensive okulare Mittel.
NO894086D0 (no) Fremgangsmaate for fremstilling av piperidinylbenzimidazoler.
DE122004000043I2 (de) Carbostyril-Derivate.
DE69009785D1 (de) Carbostyrilderivate.
ES2106825T3 (es) Derivados de piperidina.
FI904734A0 (fi) Anordning foer maetning av tryckdifferens.
FI904735A0 (fi) Anordning foer maetning av tryckdifferens.
FI873626A (fi) Derivat av 2,5-dihydrofuran med en triazol- eller imidazolgrupp, framstaellningsfoerfarande anvaendning som fungicid.
FI894717A (fi) Anordning foer maetning av lokalt och tidsavhaengigt upptraedande svaga biomagnetiska faelt i kroppen hos en patient.
NO895136D0 (no) Apparat for nedfiring av personer fra bygninger o.l.
DE69201302D1 (de) Therapeutische zusammenstellungen auf der basis von 1,2-dithiole-3-thionderivaten.
FI904676A0 (fi) Anordning foer loesgoerande av manteln i en haeftapparat.
NO883070D0 (no) 4-aminosubstituerte 1,2-dihydroksynaftalin-derivater.
FI920853A0 (fi) Anordning foer fjaerrtestning av ledningar.
FI890370A (fi) Foereningar med psykotrop inverkan, dessa innehaollande laekemedel och deras anvaendning vid behandling och profylax av stoerningar i det centrala nervsystemet.
FI873625A (fi) Derivat av 2,3-dihydrofuran, deras framstaellningsfoerfarande och anvaendning som mellanprodukt foer framstaellning av tetrahydrofuran.
NO891990D0 (no) Apparat for funksjonsproevning av sikkerhetsbelysning.
FI901245A0 (fi) Foerfarande foer framstaellning av en relieftryckplatta med en klibbfri tryckande yta.
FI910048A0 (fi) Foerfarande och arrangemang av formningsgap foer att kontrollera laeppstraolen i gapformaren av en pappersmaskin.
NO910564D0 (no) Fremgangsmaate for fremstilling av azaspiro(4,5)decan-7,9-dionderivater.
FI912445A0 (fi) Inspaenning av vira.
FI912816A0 (fi) Passare foer underlaettande av uppritning av ellips.
FI913516A (fi) Anordning foer syresaettning av vatten, saerskilt i naturbassaenger, saosom sjoear
FI922420A0 (fi) Moderniserad foervaermare foer foervarmning av luft i t.ex. masugnsanlaeggningar.

Legal Events

Date Code Title Description
FD Application lapsed

Owner name: MERCK SHARP & DOHME LIMITED