FI883247A7 - 7-/1h-pyrrool-3-yl/-substituerade 3,5-dihydroxihept-6-ensyror, 7-/1h-pyrrol-3-yl/-susbtituerade 3,5 -dihydroxiheptansyror, motsvarande -laktoner och salter av dem, foerfarande foer framstaellning av dessa, deras anvaendning som laekemedel, farmaceutiska preparat och mellanprodukter. - Google Patents

7-/1h-pyrrool-3-yl/-substituerade 3,5-dihydroxihept-6-ensyror, 7-/1h-pyrrol-3-yl/-susbtituerade 3,5 -dihydroxiheptansyror, motsvarande -laktoner och salter av dem, foerfarande foer framstaellning av dessa, deras anvaendning som laekemedel, farmaceutiska preparat och mellanprodukter. Download PDF

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Publication number
FI883247A7
FI883247A7 FI883247A FI883247A FI883247A7 FI 883247 A7 FI883247 A7 FI 883247A7 FI 883247 A FI883247 A FI 883247A FI 883247 A FI883247 A FI 883247A FI 883247 A7 FI883247 A7 FI 883247A7
Authority
FI
Finland
Prior art keywords
pyrrol
och
susbtituerade
laktoner
farmaceutiska
Prior art date
Application number
FI883247A
Other languages
English (en)
Finnish (fi)
Other versions
FI883247A0 (fi
Inventor
Heiner Jendralla
Gerhard Beck
Ekkehard Baader
Bela Kerekjarto
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI883247A0 publication Critical patent/FI883247A0/fi
Publication of FI883247A7 publication Critical patent/FI883247A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI883247A 1987-07-10 1988-07-07 7-/1h-pyrrool-3-yl/-substituerade 3,5-dihydroxihept-6-ensyror, 7-/1h-pyrrol-3-yl/-susbtituerade 3,5 -dihydroxiheptansyror, motsvarande -laktoner och salter av dem, foerfarande foer framstaellning av dessa, deras anvaendning som laekemedel, farmaceutiska preparat och mellanprodukter. FI883247A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873722806 DE3722806A1 (de) 1987-07-10 1987-07-10 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte

Publications (2)

Publication Number Publication Date
FI883247A0 FI883247A0 (fi) 1988-07-07
FI883247A7 true FI883247A7 (fi) 1989-01-11

Family

ID=6331291

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883247A FI883247A7 (fi) 1987-07-10 1988-07-07 7-/1h-pyrrool-3-yl/-substituerade 3,5-dihydroxihept-6-ensyror, 7-/1h-pyrrol-3-yl/-susbtituerade 3,5 -dihydroxiheptansyror, motsvarande -laktoner och salter av dem, foerfarande foer framstaellning av dessa, deras anvaendning som laekemedel, farmaceutiska preparat och mellanprodukter.

Country Status (19)

Country Link
US (1) US5055484A (enExample)
EP (1) EP0300249B1 (enExample)
JP (1) JPS6434959A (enExample)
KR (1) KR890002135A (enExample)
AT (1) ATE85324T1 (enExample)
AU (1) AU1888088A (enExample)
DE (2) DE3722806A1 (enExample)
DK (1) DK384288A (enExample)
ES (1) ES2043736T3 (enExample)
FI (1) FI883247A7 (enExample)
GR (1) GR3007611T3 (enExample)
HU (1) HU208672B (enExample)
IE (1) IE63205B1 (enExample)
IL (1) IL87036A0 (enExample)
NO (1) NO883072L (enExample)
NZ (1) NZ225342A (enExample)
PH (1) PH26375A (enExample)
PT (1) PT87927B (enExample)
ZA (1) ZA884918B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3826814A1 (de) * 1988-08-06 1990-02-08 Hoechst Ag Neue 6-fluor-3,5-dihydroxycarbonsaeuren und deren derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
IT1237793B (it) * 1989-12-21 1993-06-17 Zambon Spa Composti attivi come inibitori dell'enzima hmg-coa reduttasi
US5128366A (en) * 1990-07-05 1992-07-07 Shinogi & Co., Ltd. Pyrrole derivatives
DE4243279A1 (de) * 1992-12-21 1994-06-23 Bayer Ag Substituierte Triole
US7250444B2 (en) * 2003-08-11 2007-07-31 Pfizer Inc. Pyrrole-based HMG-CoA reductase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3928380A (en) * 1973-03-29 1975-12-23 Sterling Drug Inc 1,1{40 -Spirobis(cyclopenta-{8 4,5-c{9 pyrroles)
US4647576A (en) * 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
KR900001212B1 (ko) * 1985-10-25 1990-02-28 산도즈 파마슈티칼스 코오포레이숀 메바로노락톤 및 그것의 유도체의 헤테로사이클릭 유사체 및 그것의 생산방법 및 약학적인 그것의 용도
US4851427A (en) * 1985-10-25 1989-07-25 Sandoz Pharm. Corp. Pyrrole analogs of mevalonolactone, derivatives thereof and pharmaceutical use
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
NO881411L (no) * 1987-04-14 1988-10-17 Bayer Ag Substituerte pyrroler.

Also Published As

Publication number Publication date
AU1888088A (en) 1989-01-12
IE63205B1 (en) 1995-04-05
JPS6434959A (en) 1989-02-06
ES2043736T3 (es) 1994-01-01
US5055484A (en) 1991-10-08
DK384288D0 (da) 1988-07-08
FI883247A0 (fi) 1988-07-07
HUT48580A (en) 1989-06-28
IE882097L (en) 1989-01-10
HU208672B (en) 1993-12-28
DK384288A (da) 1989-01-11
KR890002135A (ko) 1989-04-08
IL87036A0 (en) 1988-12-30
DE3878067D1 (de) 1993-03-18
PT87927A (pt) 1989-06-30
GR3007611T3 (enExample) 1993-08-31
EP0300249B1 (de) 1993-02-03
PH26375A (en) 1992-06-01
NO883072L (no) 1989-01-11
ATE85324T1 (de) 1993-02-15
EP0300249A1 (de) 1989-01-25
ZA884918B (en) 1989-01-18
DE3722806A1 (de) 1989-01-19
NO883072D0 (no) 1988-07-08
NZ225342A (en) 1991-03-26
PT87927B (pt) 1995-03-01

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