FI873609A - Chemiluminescent acridine derivatives, their preparation and their use in luminescence immunoassays - Google Patents

Chemiluminescent acridine derivatives, their preparation and their use in luminescence immunoassays Download PDF

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Publication number
FI873609A
FI873609A FI873609A FI873609A FI873609A FI 873609 A FI873609 A FI 873609A FI 873609 A FI873609 A FI 873609A FI 873609 A FI873609 A FI 873609A FI 873609 A FI873609 A FI 873609A
Authority
FI
Finland
Prior art keywords
group
preparation
luminescence immunoassays
acridine derivatives
hydrogen
Prior art date
Application number
FI873609A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI873609A0 (en
FI90542C (en
FI90542B (en
Inventor
Peter Molz
Hans-Juergen Skrzipczyk
Henning Luebbers
Helmut Strecker
Gerd Schnorr
Tonio Kinkel
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI873609A0 publication Critical patent/FI873609A0/en
Publication of FI873609A publication Critical patent/FI873609A/en
Application granted granted Critical
Publication of FI90542B publication Critical patent/FI90542B/en
Publication of FI90542C publication Critical patent/FI90542C/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

The invention relates to novel acridinium derivatives of the formula I: <IMAGE> in which R<1> is hydrogen, an alkyl, alkenyl or alkynyl radical having 1 to 10 carbon atoms, a benzyl or aryl group, R<2> and R<3> are hydrogen, an alkyl group having 1 to 4 carbon atoms, a substituted or unsubstituted amino group, a carboxyl, C1-C4-alkoxy, cyano or nitro group or halogen, R<4> is a radical in which a sulphonamide group is bonded directly to the carbonyl group via the nitrogen and A<(-)> is an anion which does not interfere with the chemiluminescence; and their use in luminescence immunoassays.
FI873609A 1986-08-22 1987-08-20 Chemiluminescent acridine derivatives, their preparation and their use in luminescence immunoassays FI90542C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3628573 1986-08-22
DE3628573A DE3628573C2 (en) 1986-08-22 1986-08-22 Chemiluminescent acridine derivatives, processes for their preparation and their use in luminescence immunoassays

Publications (4)

Publication Number Publication Date
FI873609A0 FI873609A0 (en) 1987-08-20
FI873609A true FI873609A (en) 1988-02-23
FI90542B FI90542B (en) 1993-11-15
FI90542C FI90542C (en) 1994-02-25

Family

ID=6307971

Family Applications (1)

Application Number Title Priority Date Filing Date
FI873609A FI90542C (en) 1986-08-22 1987-08-20 Chemiluminescent acridine derivatives, their preparation and their use in luminescence immunoassays

Country Status (12)

Country Link
EP (2) EP0257541B1 (en)
JP (2) JPH0699401B2 (en)
AT (2) ATE132490T1 (en)
CA (1) CA1341402C (en)
DE (4) DE3628573C2 (en)
DK (1) DK171437B1 (en)
ES (2) ES2083949T3 (en)
FI (1) FI90542C (en)
GR (1) GR3019470T3 (en)
IE (1) IE74678B1 (en)
NO (1) NO171725C (en)
PT (1) PT85563B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0082636B2 (en) * 1981-12-11 2006-10-18 The Welsh National School of Medicine Luminescent labelling materials and procedures
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
ES2063735T3 (en) * 1986-10-22 1995-01-16 Abbott Lab CHEMI-LUMINISCENT ACRIDINY SALTS.
FR2625565A1 (en) * 1987-12-31 1989-07-07 London Diagnostics Inc Improved chemiluminescent esters, thioesters and amides, and analyses employing them
NZ227506A (en) * 1987-12-31 1992-06-25 London Diagnostics Inc Specific binding assays using chemiluminescent compounds
DE3844954C2 (en) * 1988-02-20 1998-07-16 Hoechst Ag Special chemiluminescent acridine derivatives and their use in luminescent immunoassays
US6002007A (en) * 1988-02-20 1999-12-14 Dade Behring Marburg Gmbh Special chemiluminescent acridine derivatives and the use thereof in luminescence immunoassays
US4950613A (en) * 1988-02-26 1990-08-21 Gen-Probe Incorporated Proteted chemiluminescent labels
AU634716B2 (en) * 1988-08-01 1993-03-04 Ciba Corning Diagnostics Corp. Method for detection of an analyte using acridinium esters and liposomes
US5227489A (en) * 1988-08-01 1993-07-13 Ciba Corning Diagnostics Corp. Stable hydrophilic acridinium esters suitable for liposome encapsulation
US5241070A (en) * 1988-09-26 1993-08-31 Ciba Corning Diagnostics Corp. Nucleophilic polysubstituted aryl acridinium esters and uses thereof
US5663074A (en) * 1988-09-26 1997-09-02 Chiron Diagnostics Corporation Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof
WO1992009580A1 (en) * 1990-11-21 1992-06-11 Beckman Instruments, Inc. Chemiluminescent compounds
DE4041080A1 (en) 1990-12-21 1992-06-25 Behringwerke Ag METHOD FOR DETERMINING AN ANALYT
DE4228839A1 (en) 1992-08-29 1994-03-03 Behringwerke Ag Methods for the detection and determination of mediators
US5491072A (en) * 1993-05-17 1996-02-13 Lumigen, Inc. N-alkylacridan carboxyl derivatives useful for chemiluminescent detection
BE1008216A4 (en) * 1994-01-25 1996-02-20 Biocode Sa HETEROCYCLIC CHEMOLUMINESCENT DERIVATIVES.
JP3866763B2 (en) * 1994-06-24 2007-01-10 デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング Method for stabilizing hydrolysis-sensitive molecules or molecular parts
JPH10502958A (en) * 1994-07-15 1998-03-17 アボツト・ラボラトリーズ Enhanced chemiluminescence signal
WO1996027785A1 (en) * 1995-03-03 1996-09-12 Abbott Laboratories Article and method for conducting chemiluminescent reaction
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
EP0761652A1 (en) * 1995-08-01 1997-03-12 Mochida Pharmaceutical Co., Ltd. Acridinium compound having a plurality of luminescent groups and binding groups, and conjugate thereof
WO1997033884A1 (en) * 1996-03-15 1997-09-18 Ss Pharmaceutical Co., Ltd. Reagents for labeling sh groups, process for the preparation of them, and method for labeling with them
US6030803A (en) * 1996-07-16 2000-02-29 De Staat Der Nederlanden, Vertegenwoordigd Door De Minister Van Welzijn, Volksgeszonheid En Cultuur Dibenzodihydropyridinecarboxylic esters and their use in chemiluminescent assay methods
BE1011206A4 (en) * 1997-06-11 1999-06-01 Biocode Sa HETEROCYCLIC DERIVATIVES chemiluminescent.
EP1496050A1 (en) 2003-07-08 2005-01-12 Roche Diagnostics GmbH Novel chemiluminescent compounds and their use
WO2005015215A1 (en) 2003-07-30 2005-02-17 Roche Diagnostics Gmbh Novel chemiluminescent compounds and their use
WO2005015214A1 (en) 2003-07-30 2005-02-17 Roche Diagnostics Gmbh Novel chemiluminescent compounds and their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1461877A (en) * 1974-02-12 1977-01-19 Wellcome Found Assay method utilizing chemiluminescence
GB2008247B (en) * 1977-11-17 1982-12-15 Welsh Nat School Med Detecting or quantifying substances using labelling techniques
EP0082636B2 (en) * 1981-12-11 2006-10-18 The Welsh National School of Medicine Luminescent labelling materials and procedures

Also Published As

Publication number Publication date
IE872245L (en) 1988-02-22
NO873520L (en) 1988-02-23
EP0257541A3 (en) 1988-11-30
DE3752357D1 (en) 2002-10-17
DE3645292C2 (en) 1997-12-11
ES2083949T3 (en) 1996-05-01
IE960911L (en) 1988-02-22
EP0257541B1 (en) 1996-01-03
ATE223903T1 (en) 2002-09-15
DK437187D0 (en) 1987-08-21
JPS6357572A (en) 1988-03-12
ATE132490T1 (en) 1996-01-15
NO171725B (en) 1993-01-18
NO171725C (en) 1993-04-28
EP0647628B1 (en) 2002-09-11
FI873609A0 (en) 1987-08-20
EP0257541A2 (en) 1988-03-02
CA1341402C (en) 2002-11-26
FI90542C (en) 1994-02-25
NO873520D0 (en) 1987-08-20
DE3751659D1 (en) 1996-02-15
DE3628573C2 (en) 1994-10-13
DK437187A (en) 1988-02-23
PT85563A (en) 1987-09-01
JPH0699401B2 (en) 1994-12-07
DE3628573A1 (en) 1988-02-25
IE74678B1 (en) 1997-07-30
EP0647628A1 (en) 1995-04-12
FI90542B (en) 1993-11-15
ES2182835T3 (en) 2003-03-16
PT85563B (en) 1990-05-31
JPH07179428A (en) 1995-07-18
JP2766780B2 (en) 1998-06-18
DK171437B1 (en) 1996-10-28
GR3019470T3 (en) 1996-06-30

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PC Transfer of assignment of patent

Owner name: DADE BEHRING MARBURG GMBH

FG Patent granted

Owner name: DADE BEHRING MARBURG GMBH

MA Patent expired