FI861506A7 - Foerfarande foer framstaellning av 1,2-ditiolan-3-pentansyra (tioktsyra). - Google Patents

Foerfarande foer framstaellning av 1,2-ditiolan-3-pentansyra (tioktsyra). Download PDF

Info

Publication number
FI861506A7
FI861506A7 FI861506A FI861506A FI861506A7 FI 861506 A7 FI861506 A7 FI 861506A7 FI 861506 A FI861506 A FI 861506A FI 861506 A FI861506 A FI 861506A FI 861506 A7 FI861506 A7 FI 861506A7
Authority
FI
Finland
Prior art keywords
acid
pentaneous
ditiolan
foerfarande foer
foer framstaellning
Prior art date
Application number
FI861506A
Other languages
English (en)
Finnish (fi)
Other versions
FI861506A0 (fi
Inventor
Guenes Giray
Klaus Huthmacher
Axel Kleemann
Thomas Lied
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of FI861506A0 publication Critical patent/FI861506A0/fi
Publication of FI861506A7 publication Critical patent/FI861506A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
FI861506A 1985-04-11 1986-04-09 Foerfarande foer framstaellning av 1,2-ditiolan-3-pentansyra (tioktsyra). FI861506A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853512911 DE3512911A1 (de) 1985-04-11 1985-04-11 Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure)

Publications (2)

Publication Number Publication Date
FI861506A0 FI861506A0 (fi) 1986-04-09
FI861506A7 true FI861506A7 (fi) 1986-10-12

Family

ID=6267677

Family Applications (1)

Application Number Title Priority Date Filing Date
FI861506A FI861506A7 (fi) 1985-04-11 1986-04-09 Foerfarande foer framstaellning av 1,2-ditiolan-3-pentansyra (tioktsyra).

Country Status (9)

Country Link
US (3) US4705867A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0197407B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JPS61236775A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE47138T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD251750A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3512911A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8703451A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI861506A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HUT40638A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3629116A1 (de) * 1986-08-27 1988-03-10 Asta Pharma Ag Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer
AT500684B8 (de) * 1989-11-09 2006-11-15 Meda Pharma Gmbh & Co Kg Verwendung von schwefelhältigen carbonsäuren zur herstellung eines arzneimittels zur bekämpfung von erkrankungen durch retroviren
DE4035442B4 (de) * 1989-11-09 2010-04-29 Evonik Degussa Gmbh Arzneimittel enthaltend als Wirkstoff R-α-Liponsäure
DE4037440A1 (de) * 1990-11-24 1992-05-27 Basf Ag Verfahren zur herstellung von (6s)-6,8-dihydroxyoctansaeureestern
DE4229914A1 (de) * 1992-09-08 1994-03-10 Basf Ag Verbessertes Verfahren zur Herstellung von R/S-Ï-Liponsäure oder R/S-â-Liponsäure
DE9213914U1 (de) * 1992-10-15 1992-12-03 Asta Medica AG, 6000 Frankfurt Ampulle und Infusionslösung von Thioctsäure in Form der wasserlöslichen Salze der Thioctsäure
EP0855396A1 (en) * 1997-01-22 1998-07-29 ASTA Medica Aktiengesellschaft Thioctic acid metabolites and methods of use thereof
US20050085498A1 (en) * 1998-05-28 2005-04-21 Byrd Edward A. Oral formulation of lipid soluble thiamine, lipoic acid, creatine derivative, and L-arginine alpha-ketoglutarate
US6191162B1 (en) 1998-05-28 2001-02-20 Medical Research Institute Method of reducing serum glucose levels
US6905707B2 (en) * 1998-05-28 2005-06-14 Medical Research Institute Controlled release arginine alpha ketoglutarate
US20040259895A1 (en) * 1998-05-28 2004-12-23 Medical Research Institute Oral formulation of lipid soluble thiamine and lipoic acid
US6197340B1 (en) 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
MXPA01004152A (es) * 1998-10-26 2002-06-04 Univ New York State Res Found Derivados de acido lipoico y su uso en el tratamiento de enfermedades.
US6664287B2 (en) * 2000-03-15 2003-12-16 Bethesda Pharmaceuticals, Inc. Antioxidants
US20070272320A1 (en) * 2006-05-24 2007-11-29 James Roberson Reusable duct wrap
PL2144609T3 (pl) 2007-04-18 2015-04-30 Cornerstone Pharmaceuticals Inc Formulacje farmaceutyczne zawierające pochodne kwasu liponowego
CN101765370B (zh) 2007-04-18 2014-06-25 基石制药公司 硫辛酸衍生物
US8263653B2 (en) 2007-04-18 2012-09-11 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives
WO2010065069A2 (en) * 2008-12-01 2010-06-10 In Vasc Therapeutics, Inc. Compositions comprising renin-angiotensin aldosterone system inhibitors and lipoic acid compounds, and the use thereof for the treatment of renin-angiotensin aldosterone system related disorders
CA2965898C (en) 2014-06-19 2021-07-06 Robert Shorr Fatty acid analogs
WO2015195070A1 (en) 2014-06-19 2015-12-23 Robert Shorr Pharmaceutical compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB762575A (en) * 1952-04-24 1956-11-28 American Cyanamid Co Omega [3-(1,2-dithiolanyl)] aliphatic acids, salts and esters and the preparation thereof
US2752374A (en) * 1952-12-10 1956-06-26 Du Pont Preparation of acids having thiol groups on the ultimate and antepenultimate carbons from the carboxyl
US2752373A (en) * 1952-12-10 1956-06-26 Du Pont Process for preparing 6, 8-dithiooctanoic acid
US2828321A (en) * 1953-10-19 1958-03-25 American Cyanamid Co Keto aliphatic acid esters and method of preparing the same
US2828322A (en) * 1953-10-19 1958-03-25 American Cyanamid Co Hydroxy thioaliphatic acids and methods of preparing the same
US2853497A (en) * 1953-12-04 1958-09-23 Merck & Co Inc 6, 8-bis (hydrocarbon substituted mercapto) 5-hydroxycaprylic acids and delta-lactones thereof
US2809978A (en) * 1953-12-04 1957-10-15 Merck & Co Inc Intermediates useful in the synthesis of alpha-lipoic acid
US3002011A (en) * 1953-12-04 1961-09-26 Merck & Co Inc Intermediates and processes for producing alpha-lipoic acid
US3049549A (en) * 1954-03-22 1962-08-14 Research Corp Lipoic acid and derivatives
US2789991A (en) * 1954-05-20 1957-04-23 American Cyanamid Co Substituted disulfones
US2792406A (en) * 1954-06-01 1957-05-14 Du Pont Process of preparing alpha-lipoic acid using dichlorooctanoate and metal disulfide
US2980716A (en) * 1954-06-11 1961-04-18 Research Corp Method for preparing 6, 8-dihalooctanoic esters
US2975198A (en) * 1954-07-08 1961-03-14 Research Corp Lipoic acid intermediates
US3033882A (en) * 1958-04-17 1962-05-08 Rech S Et Propagande Scient Octanoic esters and processes for their preparation and utilization
US3223712A (en) * 1960-07-18 1965-12-14 Yamanouchi Pharma Co Ltd Synthesis of thioctic acid and thioctic acid amide

Also Published As

Publication number Publication date
FI861506A0 (fi) 1986-04-09
US4705867A (en) 1987-11-10
JPS61236775A (ja) 1986-10-22
ES8703451A1 (es) 1987-02-16
US4800044A (en) 1989-01-24
DE3666226D1 (en) 1989-11-16
ES553850A0 (es) 1987-02-16
ATE47138T1 (de) 1989-10-15
DE3512911A1 (de) 1986-10-16
EP0197407A3 (en) 1987-09-02
EP0197407A2 (de) 1986-10-15
JPH0351702B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-08-07
US4966732A (en) 1990-10-30
EP0197407B1 (de) 1989-10-11
JPS63183558A (ja) 1988-07-28
HUT40638A (en) 1987-01-28
JPH0348188B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-07-23
DD251750A5 (de) 1987-11-25

Similar Documents

Publication Publication Date Title
FI864237L (fi) Foerfarande foer framstaellning av 1,6-diklor-1,6-dideoxi- -d-fruktofuranosyl-4-klor-4-deoxi- -galaktopyranosider.
FI861506A7 (fi) Foerfarande foer framstaellning av 1,2-ditiolan-3-pentansyra (tioktsyra).
DE3669876D1 (de) 3,4-dihydrobenzopyranderivate.
FI863597L (fi) Foerfarande foer framstaellning av tetrafluorbensoesyra.
FI892675L (fi) 2,6-dihalogenpyridin-3 -karboxylsyraderivat och deras framstaellning.
FI861561A7 (fi) Substituerad 2,3,4,9-tetrahydro-1h -karbazol-1-aettikasyra.
FI861416L (fi) Foerfarande foer framstaellning av farmakologiskt aktiva 2,3,4,5-tetrahydro-lh-3-benzazepiner.
FI870869L (fi) Framstaellande av indoli-alfa-ketosyror fraon aminosyra, speciellt fraon indolipyrodruvsyra.
FI850533L (fi) Foerfarande foer anordning av rullar, i synnerhet pappersrullar i en foerpackning laemplig foer leverans.
IT8521944A0 (it) 1,4-diidropiridine-2-sostituite.
FI86060B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 1,4-naftalendioner.
FI862343A7 (fi) Foerfarande foer framstaellning av terapeutiskt verkande 1,4-dihydropyridinfoereningar.
FI865128L (fi) Nya 16,17-acetalsubstituerade pregnan-21-karboxylsyraderivat.
FI860247L (fi) Foerfarande foer framstaellning av 4,4-dialkyl-2-azetidinoner.
FI861951A7 (fi) 1,3-oxatianderivat.
FI855182L (fi) Foerfarande foer framstaellning av 1,3 -disubstituerade tetrahydropyridiner.
FI861275A7 (fi) Foerfarande foer framstaellning av farmakologiskt aktiva 16,17-asetalsubstituerade androstan-17 -karboxylsyraestrar.
FI865244A7 (fi) Foerfarande foer framstaellning av optiskt aktiva 2-klor-12-(3-dimetylamino-2-metylpropyl)-12h-dibenzo-/d,g//1,3,6/ dioxazociner.
NO863304D0 (no) 7-okso-4-tia-1-azabicyklo(3,2,0)hept-2-derivater.
FI861950A0 (fi) 1,3-dioxan-etrar.
FI862965A7 (fi) Foerfarande foer framstaellning av kef-3-em-4-karboxylsyraderivat.
FI865158A7 (fi) 1-h-pyrido/3,2//1,4/-tiaziner.
FI854985L (fi) Foerfarande foer framstaellning av farmaceutiskt aktiva n-substituerade aziridin-2-karboxylsyraderivat.
ATE58735T1 (de) 5-chloro-s-triazolo(4,3-a>pyridin-7-carbonsaeure .
NO880088D0 (no) 2,1-benzotiazepin-2,2-dioksyd-5-karboksylsyrederivater.

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: DEGUSSA AKTIENGESELLSCHAFT