FI85582C - Foerfarande foer framstaellning av ett terapeutiskt aktivt fluorerad diaminoalkynderivat. - Google Patents
Foerfarande foer framstaellning av ett terapeutiskt aktivt fluorerad diaminoalkynderivat. Download PDFInfo
- Publication number
- FI85582C FI85582C FI870139A FI870139A FI85582C FI 85582 C FI85582 C FI 85582C FI 870139 A FI870139 A FI 870139A FI 870139 A FI870139 A FI 870139A FI 85582 C FI85582 C FI 85582C
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- Finland
- Prior art keywords
- formula
- compound
- group
- phthalimido
- tumor
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- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- QQWYQAQQADNEIC-UHFFFAOYSA-N tert-butyl [[cyano(phenyl)methylidene]amino] carbonate Chemical compound CC(C)(C)OC(=O)ON=C(C#N)C1=CC=CC=C1 QQWYQAQQADNEIC-UHFFFAOYSA-N 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000000015 thermotherapy Methods 0.000 description 1
- YUKQRDCYNOVPGJ-UHFFFAOYSA-N thioacetamide Chemical compound CC(N)=S YUKQRDCYNOVPGJ-UHFFFAOYSA-N 0.000 description 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 1
- 229960001196 thiotepa Drugs 0.000 description 1
- 229960003087 tioguanine Drugs 0.000 description 1
- 125000005425 toluyl group Chemical group 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 125000005424 tosyloxy group Chemical group S(=O)(=O)(C1=CC=C(C)C=C1)O* 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 201000002311 trypanosomiasis Diseases 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
- C07C211/24—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
- C07C211/23—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton the carbon skeleton containing carbon-to-carbon triple bonds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81884886 | 1986-01-14 | ||
| US06/818,848 US4707498A (en) | 1986-01-14 | 1986-01-14 | Fluorinated diaminoalkyne derivatives |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI870139A0 FI870139A0 (fi) | 1987-01-14 |
| FI870139L FI870139L (fi) | 1987-07-15 |
| FI85582B FI85582B (fi) | 1992-01-31 |
| FI85582C true FI85582C (fi) | 1992-05-11 |
Family
ID=25226588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI870139A FI85582C (fi) | 1986-01-14 | 1987-01-14 | Foerfarande foer framstaellning av ett terapeutiskt aktivt fluorerad diaminoalkynderivat. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4707498A (de) |
| EP (1) | EP0229658B1 (de) |
| JP (1) | JP2520244B2 (de) |
| KR (1) | KR900006748B1 (de) |
| CN (1) | CN1013491B (de) |
| AR (1) | AR241898A1 (de) |
| AT (1) | ATE55596T1 (de) |
| AU (1) | AU589245B2 (de) |
| CA (1) | CA1269996A (de) |
| DE (1) | DE3764276D1 (de) |
| DK (1) | DK14987A (de) |
| ES (1) | ES2016570B3 (de) |
| FI (1) | FI85582C (de) |
| GR (1) | GR3000786T3 (de) |
| HU (1) | HU199772B (de) |
| IL (1) | IL81213A (de) |
| NO (1) | NO165917C (de) |
| NZ (1) | NZ218890A (de) |
| PT (1) | PT84100B (de) |
| ZA (1) | ZA87159B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH085845B2 (ja) * | 1987-05-12 | 1996-01-24 | 住友化学工業株式会社 | エステル化合物およびそれを有効成分とする殺虫剤 |
| IL83086A (en) * | 1987-07-06 | 1991-03-10 | Teva Pharma | Stable,injectable solutions of vincristine salts |
| EP0369944A1 (de) * | 1988-11-18 | 1990-05-23 | Ciba-Geigy Ag | Substituierte Oxadiaminobutane |
| IL97759A0 (en) * | 1990-04-11 | 1992-06-21 | Ciba Geigy Ag | Hydroxylamine compounds |
| IL121789A (en) * | 1996-10-03 | 2001-06-14 | Rohm & Haas | A medicinal product for inhibiting mammalian cell tumors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4139563A (en) * | 1977-07-01 | 1979-02-13 | Merrell Toraude Et Compagnie | α-ACETYLENIC DERIVATIVES OF AMINES |
| US4193563A (en) * | 1977-12-01 | 1980-03-18 | Carmen Vitale | Apparatus for carrying and dispensing cable |
| IE54304B1 (en) * | 1981-08-19 | 1989-08-16 | Merrell Dow France | Fluorinated diamino-heptene and -heptyne derivatives |
| US4421768A (en) * | 1982-08-11 | 1983-12-20 | Merrell Toraude Et Compagnie | Fluorinated diamino-heptene and-heptyne derivatives |
-
1986
- 1986-01-14 US US06/818,848 patent/US4707498A/en not_active Expired - Lifetime
-
1987
- 1987-01-09 IL IL81213A patent/IL81213A/xx not_active IP Right Cessation
- 1987-01-09 ZA ZA87159A patent/ZA87159B/xx unknown
- 1987-01-09 AR AR87306437A patent/AR241898A1/es active
- 1987-01-12 AU AU67477/87A patent/AU589245B2/en not_active Ceased
- 1987-01-12 NZ NZ218890A patent/NZ218890A/xx unknown
- 1987-01-13 HU HU87101A patent/HU199772B/hu not_active IP Right Cessation
- 1987-01-13 JP JP62004225A patent/JP2520244B2/ja not_active Expired - Fee Related
- 1987-01-13 DK DK014987A patent/DK14987A/da unknown
- 1987-01-13 ES ES87100336T patent/ES2016570B3/es not_active Expired - Lifetime
- 1987-01-13 EP EP87100336A patent/EP0229658B1/de not_active Expired - Lifetime
- 1987-01-13 CN CN87100255A patent/CN1013491B/zh not_active Expired
- 1987-01-13 KR KR1019870000188A patent/KR900006748B1/ko not_active Expired
- 1987-01-13 AT AT87100336T patent/ATE55596T1/de active
- 1987-01-13 NO NO870128A patent/NO165917C/no unknown
- 1987-01-13 CA CA000527188A patent/CA1269996A/en not_active Expired - Fee Related
- 1987-01-13 PT PT84100A patent/PT84100B/pt unknown
- 1987-01-13 DE DE8787100336T patent/DE3764276D1/de not_active Expired - Fee Related
- 1987-01-14 FI FI870139A patent/FI85582C/fi not_active IP Right Cessation
-
1990
- 1990-09-12 GR GR90400644T patent/GR3000786T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3000786T3 (en) | 1991-10-10 |
| HUT46650A (en) | 1988-11-28 |
| US4707498A (en) | 1987-11-17 |
| ATE55596T1 (de) | 1990-09-15 |
| HU199772B (en) | 1990-03-28 |
| IL81213A0 (en) | 1987-08-31 |
| CN87100255A (zh) | 1987-09-30 |
| FI85582B (fi) | 1992-01-31 |
| DE3764276D1 (de) | 1990-09-20 |
| AU589245B2 (en) | 1989-10-05 |
| KR870007098A (ko) | 1987-08-14 |
| NO870128D0 (no) | 1987-01-13 |
| JP2520244B2 (ja) | 1996-07-31 |
| AR241898A1 (es) | 1993-01-29 |
| PT84100B (pt) | 1989-02-28 |
| IL81213A (en) | 1990-08-31 |
| EP0229658B1 (de) | 1990-08-16 |
| FI870139L (fi) | 1987-07-15 |
| DK14987A (da) | 1987-07-15 |
| DK14987D0 (da) | 1987-01-13 |
| JPS62167744A (ja) | 1987-07-24 |
| FI870139A0 (fi) | 1987-01-14 |
| NO165917C (no) | 1991-05-02 |
| CN1013491B (zh) | 1991-08-14 |
| CA1269996A (en) | 1990-06-05 |
| NZ218890A (en) | 1989-10-27 |
| ES2016570B3 (es) | 1990-11-16 |
| EP0229658A1 (de) | 1987-07-22 |
| KR900006748B1 (ko) | 1990-09-20 |
| PT84100A (en) | 1987-02-01 |
| NO870128L (no) | 1987-07-15 |
| ZA87159B (en) | 1987-08-26 |
| NO165917B (no) | 1991-01-21 |
| AU6747787A (en) | 1987-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: MERRELL DOW PHARMACEUTICALS INC. |