FI850860A0 - FOERFARANDE FOER FRAMSTAELLNING AV S (-) - 3- / 3-ACETYL-4- (3-TERT.BUTYLAMINO-2-HYDROXIPROPOXY) -FENYL / -1,1-DIETHYLUREA. - Google Patents

FOERFARANDE FOER FRAMSTAELLNING AV S (-) - 3- / 3-ACETYL-4- (3-TERT.BUTYLAMINO-2-HYDROXIPROPOXY) -FENYL / -1,1-DIETHYLUREA.

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Publication number
FI850860A0
FI850860A0 FI850860A FI850860A FI850860A0 FI 850860 A0 FI850860 A0 FI 850860A0 FI 850860 A FI850860 A FI 850860A FI 850860 A FI850860 A FI 850860A FI 850860 A0 FI850860 A0 FI 850860A0
Authority
FI
Finland
Prior art keywords
diethylurea
acetyl
pharmaceutically acceptable
butylamino
tert
Prior art date
Application number
FI850860A
Other languages
Finnish (fi)
Other versions
FI850860L (en
FI83636B (en
FI83636C (en
Inventor
Gerhard Zoelss
Richard Gratz
Karl Schloegl
Otmar Hofer
Robert Jay Gordon
Original Assignee
Chemie Linz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemie Linz Ag filed Critical Chemie Linz Ag
Publication of FI850860A0 publication Critical patent/FI850860A0/en
Publication of FI850860L publication Critical patent/FI850860L/en
Publication of FI83636B publication Critical patent/FI83636B/en
Application granted granted Critical
Publication of FI83636C publication Critical patent/FI83636C/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Epoxy Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

1. Claims (for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) S(-)-3-[3-acetyl-4-(3-tert.butylamino-2-hydroxypropoxy) phenyl]-1,1-diethylurea (S(-)-celiprolol) and its pharmaceutically acceptable acid addition salts. 1. Claims (for the Contracting State AT) Process for the preparation of S(-)-3-[3-acetyl-4-(3-tert.butylamino-2-hydroxypropoxy) phenyl]-1,1-diethylurea (S(-)-celiprolol) and its pharmaceutically acceptable acid addition salts, characterised in that a) the racemate of the formula see diagramm : EP0155518,P10,F1 in the form of the base is reacted with an enantiomer of a chiral resolving acid in a suitable organic solvent, the mixture of the two diastereomeric salts formed in this manner is separated by fractional crystallisation, and, after separating each diastereomeric salt which contains the laevorotatory enantiomer of the compound of the formula I in the S configuration, is reconverted into the free base or a pharmaceutically acceptable addition salt and the resolving acid is recovered, or b) S(+)-3-[3-acetyl-4-(2,3-epoxypropoxy)-phenyl]- 1,1-diethylurea of the formula see diagramm : EP0155518,P10,F2 is reacted with tertiary butylamine in the presence of water at room temperature or with gentle heating to a maximum of 40 degrees C, and then the laevorotatory enantiomer of the compound of the formula I thus obtained is converted as required into a pharmaceutically acceptable addition salt.
FI850860A 1984-03-21 1985-03-04 Process for the preparation of pharmaceutically active S (-) - 3- / 3-acetyl -4- (3-tert-butylamino-2-hydroxypropoxy) phenyl / -1,1-diethylurea FI83636C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843410380 DE3410380A1 (en) 1984-03-21 1984-03-21 S (-) - CELIPROLOL, THEIR PHARMACEUTICALLY COMPATIBLE SALT, METHOD FOR THE PRODUCTION THEREOF, USE IN THERAPY AND PHARMACEUTICAL PREPARATIONS
DE3410380 1984-03-21

Publications (4)

Publication Number Publication Date
FI850860A0 true FI850860A0 (en) 1985-03-04
FI850860L FI850860L (en) 1985-09-22
FI83636B FI83636B (en) 1991-04-30
FI83636C FI83636C (en) 1991-08-12

Family

ID=6231193

Family Applications (1)

Application Number Title Priority Date Filing Date
FI850860A FI83636C (en) 1984-03-21 1985-03-04 Process for the preparation of pharmaceutically active S (-) - 3- / 3-acetyl -4- (3-tert-butylamino-2-hydroxypropoxy) phenyl / -1,1-diethylurea

Country Status (21)

Country Link
EP (1) EP0155518B1 (en)
JP (1) JPS60209557A (en)
AT (1) ATE45945T1 (en)
AU (1) AU567797B2 (en)
CA (1) CA1236116A (en)
CS (2) CS250683B2 (en)
DD (2) DD232489A1 (en)
DE (2) DE3410380A1 (en)
DK (1) DK124585A (en)
ES (1) ES541424A0 (en)
FI (1) FI83636C (en)
GR (1) GR850496B (en)
HU (1) HU193596B (en)
IL (1) IL74383A (en)
NO (1) NO161254C (en)
PL (2) PL252462A1 (en)
PT (1) PT80135B (en)
RO (2) RO91352B (en)
SU (2) SU1333235A3 (en)
YU (2) YU45707B (en)
ZA (1) ZA852086B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3636209A1 (en) * 1986-10-24 1988-04-28 Lentia Gmbh METHOD FOR PRODUCING A BINDER-FREE TABLET-TABLE CELIPROLOL HYDROCHLORIDE GRANULATE
AT388099B (en) * 1986-11-26 1989-04-25 Chemie Holding Ag Process for the production of solid pharmaceutical forms of 3-(3-acetyl-4-(3-tert-butylamino-2- hydroxypropoxy)phenyl)-1,1-diethylurea hydrochloride
US4931557A (en) * 1988-10-17 1990-06-05 Eli Lilly And Company Method of resolving cis 3-amino-4-(2-furyl)vinyl)-1-methoxycarbonylmethyl-azetidin-2-one and di-p-toluoyl-tartaric acid salts thereof
EP0423484B1 (en) * 1989-10-16 1993-11-03 PCD-Polymere Gesellschaft m.b.H. Tablet with sustained release
DE3935736A1 (en) * 1989-10-27 1991-05-02 Chemie Linz Deutschland Pressed article for sustained pharmaceutical release - contg. poly-lactic acid and polymer of D-3-hydroxybutyric acid, providing good flow properties and easy compression
US5227526A (en) * 1992-06-16 1993-07-13 Mallinckrodt Specialty Chemicals Company Resolution of 3-dimethylamino-2-methylpropiophenone (3-DAMP)
CN101239937B (en) * 2007-02-07 2010-05-19 上海雅本化学有限公司 Method for preparing optical activity R-(-)-1-benzylcarbonyl-3-aminopyrrolidine and hydrochloride thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT334385B (en) * 1973-12-20 1976-01-10 Chemie Linz Ag PROCESS FOR THE PREPARATION OF NEW PHENOXYPROPYLAMINE DERIVATIVES AND THEIR SALTS
HU170678B (en) * 1973-12-20 1977-08-28
HU170677B (en) * 1973-12-21 1977-08-28
US4470965A (en) * 1982-10-27 1984-09-11 Usv Pharmaceutical Corporation Celiprolol for the treatment of glaucoma

Also Published As

Publication number Publication date
ZA852086B (en) 1985-11-27
SU1333235A3 (en) 1987-08-23
HU193596B (en) 1987-11-30
DD234860A1 (en) 1986-04-16
SU1309908A3 (en) 1987-05-07
IL74383A (en) 1988-09-30
YU44385A (en) 1987-06-30
CS250682B2 (en) 1987-05-14
PL252462A1 (en) 1985-11-19
EP0155518A3 (en) 1986-06-25
NO161254C (en) 1989-07-26
DE3572656D1 (en) 1989-10-05
DK124585A (en) 1985-09-22
JPS60209557A (en) 1985-10-22
EP0155518A2 (en) 1985-09-25
CS250683B2 (en) 1987-05-14
CA1236116A (en) 1988-05-03
NO161254B (en) 1989-04-17
FI850860L (en) 1985-09-22
PT80135B (en) 1987-10-20
FI83636B (en) 1991-04-30
YU44485A (en) 1987-06-30
ES8603390A1 (en) 1985-12-16
DE3410380A1 (en) 1985-10-10
PT80135A (en) 1985-04-01
RO91353B (en) 1987-05-01
YU45246B (en) 1992-05-28
IL74383A0 (en) 1985-05-31
HUT37392A (en) 1985-12-28
AU3972285A (en) 1985-09-26
ATE45945T1 (en) 1989-09-15
GR850496B (en) 1985-03-15
AU567797B2 (en) 1987-12-03
ES541424A0 (en) 1985-12-16
RO91353A (en) 1987-04-30
EP0155518B1 (en) 1989-08-30
DD232489A1 (en) 1986-01-29
FI83636C (en) 1991-08-12
RO91352B (en) 1987-05-02
PL143883B1 (en) 1988-03-31
DK124585D0 (en) 1985-03-20
PL252463A1 (en) 1985-11-19
RO91352A (en) 1987-04-30
NO850834L (en) 1985-09-23
YU45707B (en) 1992-07-20

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