JPS56110678A - Preparation of alkoxycarbonylmethyl-substituted condensed pyrimidine compound - Google Patents
Preparation of alkoxycarbonylmethyl-substituted condensed pyrimidine compoundInfo
- Publication number
- JPS56110678A JPS56110678A JP1405680A JP1405680A JPS56110678A JP S56110678 A JPS56110678 A JP S56110678A JP 1405680 A JP1405680 A JP 1405680A JP 1405680 A JP1405680 A JP 1405680A JP S56110678 A JPS56110678 A JP S56110678A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- preparation
- halogen
- acid ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PURPOSE: To prepare the titled compound useful as an intermediate for the preparation of a compound having blood platelet coagulation inhibiting activity, in high yield, by reacting a novel 2-halogeno-3,4-dihydro-condensed pyrimidine compound with a halogenoacetic acid ester in the presence of phase transfer catalyst.
CONSTITUTION: A novel compound of formula I (group of formula II is benzene ring or thiophene ring which may be substituted with lower alkyl, lower alkoxy, phenyl, halogen, etc.; etc.; X1 is halogen) is made to react with a halogenoacetic acid ester of formula III (R is lower alkyl; X2 is X1) in the presence of a phase transfer catalyst such as tetra-n-butyl ammonium iodide, at room temperature for several to several tens minutes to obtain the objective compound of formula IV in an yield of as high as 80W95%. Heating of the resultant compound together with NH3 affords the compound of formula V having blood platelet coagulation inhibiting activity.
EFFECT: Mild reaction condition, easy pretreatment, and high yield separation of the objective compound.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1405680A JPS56110678A (en) | 1980-02-07 | 1980-02-07 | Preparation of alkoxycarbonylmethyl-substituted condensed pyrimidine compound |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1405680A JPS56110678A (en) | 1980-02-07 | 1980-02-07 | Preparation of alkoxycarbonylmethyl-substituted condensed pyrimidine compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56110678A true JPS56110678A (en) | 1981-09-01 |
| JPH0226631B2 JPH0226631B2 (en) | 1990-06-12 |
Family
ID=11850425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1405680A Granted JPS56110678A (en) | 1980-02-07 | 1980-02-07 | Preparation of alkoxycarbonylmethyl-substituted condensed pyrimidine compound |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56110678A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104119344A (en) * | 2014-05-30 | 2014-10-29 | 上海天慈生物谷生物工程有限公司 | Novel method for preparing 6,7-dichloro-1,5-imidazolinyl [2,1-b] quinazoline-2-(3H)-one |
-
1980
- 1980-02-07 JP JP1405680A patent/JPS56110678A/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104119344A (en) * | 2014-05-30 | 2014-10-29 | 上海天慈生物谷生物工程有限公司 | Novel method for preparing 6,7-dichloro-1,5-imidazolinyl [2,1-b] quinazoline-2-(3H)-one |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0226631B2 (en) | 1990-06-12 |
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