FI834530L - AFFINITETSRENINGSFOERFARANDE MEDELST MONOCLONALA ANTI-KROPPAR. - Google Patents

AFFINITETSRENINGSFOERFARANDE MEDELST MONOCLONALA ANTI-KROPPAR. Download PDF

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Publication number
FI834530L
FI834530L FI834530A FI834530A FI834530L FI 834530 L FI834530 L FI 834530L FI 834530 A FI834530 A FI 834530A FI 834530 A FI834530 A FI 834530A FI 834530 L FI834530 L FI 834530L
Authority
FI
Finland
Prior art keywords
antigens
environment
monoclonal antibodies
antibodies
monoclonala
Prior art date
Application number
FI834530A
Other languages
Finnish (fi)
Other versions
FI88403C (en
FI834530A0 (en
FI88403B (en
Inventor
Richard M Bartholomew
Daniel E Beidler
Gary S David
Original Assignee
Hybritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc filed Critical Hybritech Inc
Publication of FI834530A0 publication Critical patent/FI834530A0/en
Publication of FI834530L publication Critical patent/FI834530L/en
Application granted granted Critical
Publication of FI88403B publication Critical patent/FI88403B/en
Publication of FI88403C publication Critical patent/FI88403C/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention relates to a method for affinity purification of antigens and antibodies by means of monoclonal antibodies which have high affinity for the antigens in a first environment and low affinity in a second environment, where these environments are ones in which the immunochemical properties of the antigens and antibodies are not adversely affected. The invention also relates to a method for fractionation of antisera in order to obtain an antibody fraction which has similar antigen-binding properties to those exhibited by the monoclonal antibodies sensitive to the environment. The effect of varying pH on the binding capacity of two monoclonal antibodies in relation to a male growth hormone is shown in Fig. 1. <IMAGE>
FI834530A 1982-04-12 1983-12-09 MONOCLONAL ANTIKROPPAR, FOERFARANDE FOER FRAMSTAELLNING AV DESSA OCH AFFINITETSRENINGSFOERFARANDE VARI DESSA ANVAENDS FI88403C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36778182A 1982-04-12 1982-04-12
US36778182 1982-04-12
PCT/US1983/000524 WO1983003678A1 (en) 1982-04-12 1983-04-12 Method of affinity purification employing monoclonal antibodies
US8300524 1983-04-12

Publications (4)

Publication Number Publication Date
FI834530A0 FI834530A0 (en) 1983-12-09
FI834530L true FI834530L (en) 1983-12-09
FI88403B FI88403B (en) 1993-01-29
FI88403C FI88403C (en) 1993-05-10

Family

ID=23448565

Family Applications (1)

Application Number Title Priority Date Filing Date
FI834530A FI88403C (en) 1982-04-12 1983-12-09 MONOCLONAL ANTIKROPPAR, FOERFARANDE FOER FRAMSTAELLNING AV DESSA OCH AFFINITETSRENINGSFOERFARANDE VARI DESSA ANVAENDS

Country Status (11)

Country Link
EP (1) EP0105359A4 (en)
AT (1) AT393386B (en)
AU (1) AU622099B2 (en)
CA (1) CA1209907A (en)
CH (1) CH672028A5 (en)
DK (1) DK192191D0 (en)
ES (3) ES521371A0 (en)
FI (1) FI88403C (en)
GB (1) GB2128630B (en)
IT (1) IT1219779B (en)
WO (1) WO1983003678A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8328918D0 (en) * 1983-10-28 1983-11-30 Unilever Plc Alkaline phosphatase
GB8331071D0 (en) * 1983-11-22 1983-12-29 Karayiannis P Assay for dna/rna
US4666865A (en) * 1984-01-13 1987-05-19 Centocor, Inc. Immunoassay for biologically active human interferon-gamma employing unique monoclonal antibodies
US4789631A (en) * 1984-02-17 1988-12-06 Synbiotics Corporation Immunoassay for anti-dirofilaria immitis antibody
GB8426468D0 (en) * 1984-10-19 1984-11-28 Technology Licence Co Ltd Monoclonal antibodies
AU5259786A (en) * 1985-01-30 1986-08-07 United States Of America, The Monoclonal antibodies against chlamydial genes specific lipopolysaccharide
US4859611A (en) * 1985-02-28 1989-08-22 Massachusetts Institute Of Technology Affinity column and process for detection of low molecular weight toxic substances
US4818687A (en) * 1985-02-28 1989-04-04 Massachusetts Institute Of Technology Affinity column and process for detection of low molecular weight toxic substances
IL75828A (en) * 1985-07-17 1991-06-10 Univ Ramot Immobilization by biologically active proteins
NZ218336A (en) * 1985-12-09 1991-08-27 Kirin Amgen Inc Monoclonal antibodies to human pluripotent granulocyte colony stimulating factor (hpg-csf)
US5175255A (en) * 1987-03-23 1992-12-29 Amgen Inc. Methods for purification of platelet-derived growth factor
US5190859A (en) * 1987-02-26 1993-03-02 Dana-Farber Cancer Institute, Inc. Purification of LFA-3
SE468653B (en) * 1987-03-06 1993-02-22 Perstorp Biolytica ADSORBENT FOR ISOCRATIC AFFINITY CHROMATOGRAPHY
JPS6463599A (en) * 1987-05-01 1989-03-09 Xoma Corp Purification of immunoglobulin by selective anti-idiotype bond
ATE76974T1 (en) * 1987-07-14 1992-06-15 Univ Manchester PROCEDURE FOR DIAGNOSIS OF INFECTION IN WHICH LIPOPOLYSCACCHARID ANTIGENS ARE DETERMINED.
CA1323567C (en) * 1987-10-05 1993-10-26 Gene R. Nathans Method for purification of antibodies
US5372812A (en) * 1988-04-04 1994-12-13 The General Hospital Corporation Composition and method for acceleration of clot lysis
US5582862A (en) 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
US6114506A (en) * 1996-09-20 2000-09-05 General Hospital Corporation Composition and method for enhancing fibrinolysis
CA2721052C (en) * 2008-04-11 2023-02-21 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
BR112013013354A2 (en) 2010-11-30 2020-10-06 Chugai Seiyaku Kabushiki Kaisha antigen-binding molecule capable of binding to a plurality of antigen molecules repeatedly
EP2679681B2 (en) 2011-02-25 2023-11-15 Chugai Seiyaku Kabushiki Kaisha FcgammaRIIB-specific FC antibody
JP6322411B2 (en) 2011-09-30 2018-05-09 中外製薬株式会社 Antigen-binding molecules that promote the disappearance of antigens with multiple physiological activities
CN104080909A (en) 2011-11-30 2014-10-01 中外制药株式会社 A drug that contains a transporter (carrier) that enters cells to form immune complexes
MY181199A (en) 2014-12-19 2020-12-21 Chugai Pharmaceutical Co Ltd Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
TWI617580B (en) 2014-12-19 2018-03-11 中外製藥股份有限公司 Anti-c5 antibodies and methods of use
WO2017110981A1 (en) 2015-12-25 2017-06-29 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
JP6527643B2 (en) 2016-08-05 2019-06-05 中外製薬株式会社 Composition for treating or preventing IL-8 related diseases
US11608374B2 (en) 2017-01-30 2023-03-21 Chugai Seiyaku Kabushiki Kaisha Anti-sclerostin antibodies and methods of use
CN110724204B (en) * 2019-11-18 2021-10-22 广东菲鹏制药股份有限公司 Purification method of Fc fusion protein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172124A (en) * 1978-04-28 1979-10-23 The Wistar Institute Method of producing tumor antibodies
ATE14269T1 (en) * 1981-02-26 1985-08-15 Unilever Nv METHOD AND DEVICE FOR RECOVERING IMMUNOGLOBULINES.
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies

Also Published As

Publication number Publication date
IT1219779B (en) 1990-05-24
DK192191A (en) 1991-11-26
AU7256987A (en) 1987-09-03
EP0105359A4 (en) 1984-08-20
CA1209907A (en) 1986-08-19
ES8404858A1 (en) 1984-05-16
WO1983003678A1 (en) 1983-10-27
ES528000A0 (en) 1985-08-01
GB8332644D0 (en) 1984-01-11
FI88403C (en) 1993-05-10
IT8320550A0 (en) 1983-04-12
GB2128630A (en) 1984-05-02
FI834530A0 (en) 1983-12-09
AU622099B2 (en) 1992-04-02
ES521371A0 (en) 1984-05-16
ATA901983A (en) 1991-03-15
FI88403B (en) 1993-01-29
ES528001A0 (en) 1987-07-01
EP0105359A1 (en) 1984-04-18
GB2128630B (en) 1986-08-28
ES8706964A1 (en) 1987-07-01
ES8506902A1 (en) 1985-08-01
AT393386B (en) 1991-10-10
CH672028A5 (en) 1989-10-13
DK192191D0 (en) 1991-11-26

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Owner name: HYBRITECH INCORPORATED