FI834530A - AFFINITETSRENINGSFOERFARANDE MEDELST MONOCLONALA ANTI-KROPPAR. - Google Patents

AFFINITETSRENINGSFOERFARANDE MEDELST MONOCLONALA ANTI-KROPPAR. Download PDF

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Publication number
FI834530A
FI834530A FI834530A FI834530A FI834530A FI 834530 A FI834530 A FI 834530A FI 834530 A FI834530 A FI 834530A FI 834530 A FI834530 A FI 834530A FI 834530 A FI834530 A FI 834530A
Authority
FI
Finland
Prior art keywords
antigens
environment
monoclonal antibodies
antibodies
monoclonala
Prior art date
Application number
FI834530A
Other languages
Finnish (fi)
Other versions
FI88403C (en
FI834530A0 (en
FI88403B (en
Inventor
Richard M Bartholomew
Daniel E Beidler
Gary S David
Original Assignee
Hybritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc filed Critical Hybritech Inc
Publication of FI834530A publication Critical patent/FI834530A/en
Publication of FI834530A0 publication Critical patent/FI834530A0/en
Application granted granted Critical
Publication of FI88403B publication Critical patent/FI88403B/en
Publication of FI88403C publication Critical patent/FI88403C/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention relates to a method for affinity purification of antigens and antibodies by means of monoclonal antibodies which have high affinity for the antigens in a first environment and low affinity in a second environment, where these environments are ones in which the immunochemical properties of the antigens and antibodies are not adversely affected. The invention also relates to a method for fractionation of antisera in order to obtain an antibody fraction which has similar antigen-binding properties to those exhibited by the monoclonal antibodies sensitive to the environment. The effect of varying pH on the binding capacity of two monoclonal antibodies in relation to a male growth hormone is shown in Fig. 1. <IMAGE>
FI834530A 1982-04-12 1983-12-09 MONOCLONAL ANTIKROPPAR, FOERFARANDE FOER FRAMSTAELLNING AV DESSA OCH AFFINITETSRENINGSFOERFARANDE VARI DESSA ANVAENDS FI88403C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36778182A 1982-04-12 1982-04-12
US36778182 1982-04-12
PCT/US1983/000524 WO1983003678A1 (en) 1982-04-12 1983-04-12 Method of affinity purification employing monoclonal antibodies
US8300524 1983-04-12

Publications (4)

Publication Number Publication Date
FI834530A true FI834530A (en) 1983-12-09
FI834530A0 FI834530A0 (en) 1983-12-09
FI88403B FI88403B (en) 1993-01-29
FI88403C FI88403C (en) 1993-05-10

Family

ID=23448565

Family Applications (1)

Application Number Title Priority Date Filing Date
FI834530A FI88403C (en) 1982-04-12 1983-12-09 MONOCLONAL ANTIKROPPAR, FOERFARANDE FOER FRAMSTAELLNING AV DESSA OCH AFFINITETSRENINGSFOERFARANDE VARI DESSA ANVAENDS

Country Status (11)

Country Link
EP (1) EP0105359A4 (en)
AT (1) AT393386B (en)
AU (1) AU622099B2 (en)
CA (1) CA1209907A (en)
CH (1) CH672028A5 (en)
DK (1) DK192191A (en)
ES (3) ES8404858A1 (en)
FI (1) FI88403C (en)
GB (1) GB2128630B (en)
IT (1) IT1219779B (en)
WO (1) WO1983003678A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8328918D0 (en) * 1983-10-28 1983-11-30 Unilever Plc Alkaline phosphatase
GB8331071D0 (en) * 1983-11-22 1983-12-29 Karayiannis P Assay for dna/rna
US4666865A (en) * 1984-01-13 1987-05-19 Centocor, Inc. Immunoassay for biologically active human interferon-gamma employing unique monoclonal antibodies
US4789631A (en) * 1984-02-17 1988-12-06 Synbiotics Corporation Immunoassay for anti-dirofilaria immitis antibody
GB8426468D0 (en) * 1984-10-19 1984-11-28 Technology Licence Co Ltd Monoclonal antibodies
AU5259786A (en) * 1985-01-30 1986-08-07 United States Of America, The Monoclonal antibodies against chlamydial genes specific lipopolysaccharide
US4859611A (en) * 1985-02-28 1989-08-22 Massachusetts Institute Of Technology Affinity column and process for detection of low molecular weight toxic substances
US4818687A (en) * 1985-02-28 1989-04-04 Massachusetts Institute Of Technology Affinity column and process for detection of low molecular weight toxic substances
IL75828A (en) * 1985-07-17 1991-06-10 Univ Ramot Immobilization by biologically active proteins
NZ218336A (en) * 1985-12-09 1991-08-27 Kirin Amgen Inc Monoclonal antibodies to human pluripotent granulocyte colony stimulating factor (hpg-csf)
US5175255A (en) * 1987-03-23 1992-12-29 Amgen Inc. Methods for purification of platelet-derived growth factor
US5190859A (en) * 1987-02-26 1993-03-02 Dana-Farber Cancer Institute, Inc. Purification of LFA-3
SE468653B (en) * 1987-03-06 1993-02-22 Perstorp Biolytica ADSORBENT FOR ISOCRATIC AFFINITY CHROMATOGRAPHY
JPS6463599A (en) * 1987-05-01 1989-03-09 Xoma Corp Purification of immunoglobulin by selective anti-idiotype bond
JPH03500682A (en) * 1987-07-14 1991-02-14 ザ　ビクトリア　ユニヴアーシテイ　オブ　マンチエスター Diagnostic method
CA1323567C (en) * 1987-10-05 1993-10-26 Gene R. Nathans Method for purification of antibodies
US5372812A (en) * 1988-04-04 1994-12-13 The General Hospital Corporation Composition and method for acceleration of clot lysis
US5582862A (en) * 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
WO1998012334A2 (en) * 1996-09-20 1998-03-26 The General Hospital Corporation Chimeric, humanized and single chain antibodies to alpha-2-antiplasmin
NO2708559T3 (en) * 2008-04-11 2018-08-25
AU2011337704B2 (en) 2010-11-30 2017-06-15 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
KR20200103845A (en) 2011-02-25 2020-09-02 추가이 세이야쿠 가부시키가이샤 FcγRIIb-specific Fc antibody
EP3939996A1 (en) 2011-09-30 2022-01-19 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
CN104080909A (en) 2011-11-30 2014-10-01 中外制药株式会社 Drug containing carrier into cell for forming immune complex
SI3233921T1 (en) 2014-12-19 2022-01-31 Chugai Seiyaku Kabushiki Kaisha Anti-c5 antibodies and methods of use
CA2963760A1 (en) 2014-12-19 2016-06-23 Yoshinao Ruike Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
WO2017110981A1 (en) 2015-12-25 2017-06-29 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
CA3026050A1 (en) 2016-08-05 2018-02-08 Chugai Seiyaku Kabushiki Kaisha Composition for prophylaxis or treatment of il-8 related diseases
JP7191833B2 (en) 2017-01-30 2022-12-19 中外製薬株式会社 Anti-sclerostin antibodies and uses thereof
CN110724204B (en) * 2019-11-18 2021-10-22 广东菲鹏制药股份有限公司 Method for purifying Fc fusion protein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172124A (en) * 1978-04-28 1979-10-23 The Wistar Institute Method of producing tumor antibodies
WO1982002818A1 (en) * 1981-02-26 1982-09-02 Gani Mohamed Mutwahar A process and apparatus for the recovery of immunoglobulins
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies

Also Published As

Publication number Publication date
CA1209907A (en) 1986-08-19
GB2128630A (en) 1984-05-02
IT1219779B (en) 1990-05-24
IT8320550A0 (en) 1983-04-12
ATA901983A (en) 1991-03-15
WO1983003678A1 (en) 1983-10-27
ES8706964A1 (en) 1987-07-01
FI88403C (en) 1993-05-10
DK192191D0 (en) 1991-11-26
AT393386B (en) 1991-10-10
GB2128630B (en) 1986-08-28
FI834530A0 (en) 1983-12-09
ES8506902A1 (en) 1985-08-01
ES528000A0 (en) 1985-08-01
CH672028A5 (en) 1989-10-13
DK192191A (en) 1991-11-26
ES521371A0 (en) 1984-05-16
FI88403B (en) 1993-01-29
EP0105359A4 (en) 1984-08-20
EP0105359A1 (en) 1984-04-18
AU622099B2 (en) 1992-04-02
ES8404858A1 (en) 1984-05-16
AU7256987A (en) 1987-09-03
ES528001A0 (en) 1987-07-01
GB8332644D0 (en) 1984-01-11

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Owner name: HYBRITECH INCORPORATED