FI82834B - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara fenylpiperazinfosfonater. - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara fenylpiperazinfosfonater. Download PDF

Info

Publication number
FI82834B
FI82834B FI863064A FI863064A FI82834B FI 82834 B FI82834 B FI 82834B FI 863064 A FI863064 A FI 863064A FI 863064 A FI863064 A FI 863064A FI 82834 B FI82834 B FI 82834B
Authority
FI
Finland
Prior art keywords
formula
process according
compound
group
compounds
Prior art date
Application number
FI863064A
Other languages
English (en)
Finnish (fi)
Other versions
FI863064A0 (fi
FI82834C (sv
FI863064A (fi
Inventor
Robert John Chorvat
Kerry Wallace Fowler
James Patrick Snyder
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of FI863064A0 publication Critical patent/FI863064A0/fi
Publication of FI863064A publication Critical patent/FI863064A/fi
Publication of FI82834B publication Critical patent/FI82834B/fi
Application granted granted Critical
Publication of FI82834C publication Critical patent/FI82834C/sv

Links

Classifications

    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
    • G11B5/00—Recording by magnetisation or demagnetisation of a record carrier; Reproducing by magnetic means; Record carriers therefor
    • G11B5/02—Recording, reproducing, or erasing methods; Read, write or erase circuits therefor
    • G11B5/09—Digital recording
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
    • G11B5/00—Recording by magnetisation or demagnetisation of a record carrier; Reproducing by magnetic means; Record carriers therefor
    • G11B5/48—Disposition or mounting of heads or head supports relative to record carriers ; arrangements of heads, e.g. for scanning the record carrier to increase the relative speed
    • G11B5/58—Disposition or mounting of heads or head supports relative to record carriers ; arrangements of heads, e.g. for scanning the record carrier to increase the relative speed with provision for moving the head for the purpose of maintaining alignment of the head relative to the record carrier during transducing operation, e.g. to compensate for surface irregularities of the latter or for track following
    • G11B5/584—Disposition or mounting of heads or head supports relative to record carriers ; arrangements of heads, e.g. for scanning the record carrier to increase the relative speed with provision for moving the head for the purpose of maintaining alignment of the head relative to the record carrier during transducing operation, e.g. to compensate for surface irregularities of the latter or for track following for track following on tapes
    • G11B5/588—Disposition or mounting of heads or head supports relative to record carriers ; arrangements of heads, e.g. for scanning the record carrier to increase the relative speed with provision for moving the head for the purpose of maintaining alignment of the head relative to the record carrier during transducing operation, e.g. to compensate for surface irregularities of the latter or for track following for track following on tapes by controlling the position of the rotating heads
    • G11B5/592—Disposition or mounting of heads or head supports relative to record carriers ; arrangements of heads, e.g. for scanning the record carrier to increase the relative speed with provision for moving the head for the purpose of maintaining alignment of the head relative to the record carrier during transducing operation, e.g. to compensate for surface irregularities of the latter or for track following for track following on tapes by controlling the position of the rotating heads using bimorph elements supporting the heads
    • G11B5/5921—Disposition or mounting of heads or head supports relative to record carriers ; arrangements of heads, e.g. for scanning the record carrier to increase the relative speed with provision for moving the head for the purpose of maintaining alignment of the head relative to the record carrier during transducing operation, e.g. to compensate for surface irregularities of the latter or for track following for track following on tapes by controlling the position of the rotating heads using bimorph elements supporting the heads using auxiliary signals, e.g. pilot signals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (15)

1. Förfarande för framställning av nya terapeu-tiskt användbara fenylpiperazinfosfonater enligt formeln 5 I och deras farmaceutiskt godtagbara salter O / \ / -Z-P-(OEt), Ar-N n-A-( C\\
10. Vry <*> 15 väri Ar betecknar en pyridylgrupp eller en grupp med for-meln X "'φ- Y väri X, Y och W betecknar samma eller oiikä och oberoende 25 av varandra väte, C1.4-alkoxi, ^.g-alkyl eller halogen och väri A betecknar -CH2-, -CO- eller -CH(CH3)- och väri Z betecknar en bindning eller -CH2- eller -CH(CH3)-, kännetecknat därav, att en förening med for-meln 30 f~\ Ar-N^_^NH 35 26 82834 väri Ar är definierad ovan, bringas att reagera med en förening med formeln 5 0 ,-, Il -Z-P- (OEt) - 10 väri A och Z är definierade ovan och Q betecknar halogen, företrädesvis brom, eller om A är -CO-, kan gruppen Q-A-även beteckna karboxyl eller ett funktionellt derivat 15 därav.
2. Förfarande enligt patentkravet 1, känne-t e c k n a t därav, att en förening med formeln 'φ-Ο—<§τα~· Υ 25 och dess farmaceutiskt godtagbara salter framställs.
3. Förfarande enligt patentkravet 2, känne-t e c k n a t därav, att tvä av beteckningarna X, Y och 30. betecknar väte och den tredje C1.4-alkoxi eller C^-al-kyl.
4. Förfarande enligt patentkravet 2, känne-t e c k n a t därav, att beteckningen A avser gruppen -CH2-. 35 5. Förfarande enligt patentkravet 2, känne- t e c k n a t därav, att beteckningen Z avser gruppen -CH2- eller -CH(CH3)~. i 27 82834
5 XC1 OCH2CH3 eller 10 (O)-N^-CH2-^O)-CH2-'f-0C,!2CH3 15 och2ch3 eller 20 CH 0 (OV- N^^-C,,2-^)-^H-y-OCII2C,,3 \ o-cn2cn3 25 0CH 3 framställs.
6. Förfarande enligt patentkravet 2, k ä n n e -t e c k n a t därav, att beteckningen Z avser gruppen -ch2- .
7. Förfarande enligt patentkravet 2, k ä n n e -5 tecknat därav, att en förening med formeln N\_rc«^CHrf-0C^3 ' OCII-,CH och3 Z 3 15 eller 20 _;-2~^)-ch2X0CH2CH3 \ 0-CH2CH CH3 25 eller 30 ^3°-(Q)-t/ y~CH2~^0)-CH-P-0CH-CH3 och2ch3 eller 35 28 82834 \_/~~CU2~~^Oy—-CH2~ pOCH-CH3
8. Förfarande enligt patentkravet 1, k ä n n e -30 tecknat därav, att Ar betecknar pyridyl.
9. Förfarande enligt patentkravet 8, k ä n n e -tecknat därav, att en förening med formeln 35 29 82 834 ©-ο—<0Γ“ι'”! 5 framställs.
10. Förfarande enligt patentkravet 9, k ä n n e -t e c k n a t därav, att en förening med formeln 10 n _^ 0 (o; _^~cn2~<^5y~cH~y-ocH2cH3
0-CH2CII3 15 framställs.
FI863064A 1985-07-29 1986-07-25 Förfarande för framställning av nya terapeutiskt användbara fenylpiper azinfosfonater FI82834C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US76023085A 1985-07-29 1985-07-29
US76023085 1985-07-29
US06/880,560 US4704382A (en) 1985-07-29 1986-07-08 Phenylpiperazine phosphonates
US88056086 1986-07-08

Publications (4)

Publication Number Publication Date
FI863064A0 FI863064A0 (fi) 1986-07-25
FI863064A FI863064A (fi) 1987-01-30
FI82834B true FI82834B (fi) 1991-01-15
FI82834C FI82834C (sv) 1991-04-25

Family

ID=27116794

Family Applications (1)

Application Number Title Priority Date Filing Date
FI863064A FI82834C (sv) 1985-07-29 1986-07-25 Förfarande för framställning av nya terapeutiskt användbara fenylpiper azinfosfonater

Country Status (13)

Country Link
US (1) US4704382A (sv)
EP (1) EP0211346B1 (sv)
AU (1) AU595220B2 (sv)
CA (1) CA1275412C (sv)
DE (1) DE3665589D1 (sv)
DK (1) DK161090C (sv)
FI (1) FI82834C (sv)
GR (1) GR861958B (sv)
IL (1) IL79525A (sv)
NO (1) NO863037L (sv)
NZ (1) NZ216971A (sv)
PH (1) PH23037A (sv)
PT (1) PT83078B (sv)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0651625B2 (ja) * 1986-12-29 1994-07-06 株式会社大塚製薬工場 高脂質血症治療剤
CA1321751C (en) * 1989-02-21 1993-08-31 Eugene C. Crichlow Mechanism mediating ruminal stasis in ruminal lactic acidosis
EP1935885A3 (en) * 2001-05-22 2008-10-15 Neurogen Corporation Melanin concentrating hormone receptor ligands : substituted 1-benzyl-4-aryl piperazine analogues.
CA2448080A1 (en) 2001-05-22 2002-11-28 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
US7459461B2 (en) * 2001-10-19 2008-12-02 Ortho-Mcneil Pharmaceutical, Inc. Phosphonic acid compounds as inhibitors of serine proteases
AU2005228015A1 (en) * 2004-03-31 2005-10-13 Suntory Holdings Limited Adiponectin increasing agent
US20050239791A1 (en) * 2004-04-07 2005-10-27 Hutchison Alan J Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues
US7253168B2 (en) * 2004-04-07 2007-08-07 Neurogen Corporation Substituted 1-benzyl-4-substituted piperazine analogues
TW200609219A (en) * 2004-06-17 2006-03-16 Neurogen Corp Aryl-substituted piperazine derivatives
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN116134025A (zh) * 2020-09-17 2023-05-16 浙江海正药业股份有限公司 酰胺膦氧类衍生物及其制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3804836A (en) * 1972-05-26 1974-04-16 Hoechst Co American N-phenyl-n'-dialkylphosphinylalkyl-piperazines
DE3139970A1 (de) * 1981-10-08 1983-04-28 Boehringer Mannheim Gmbh, 6800 Mannheim Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
NO863037D0 (no) 1986-07-28
DK161090C (da) 1991-11-18
IL79525A0 (en) 1986-10-31
AU595220B2 (en) 1990-03-29
FI863064A0 (fi) 1986-07-25
DK161090B (da) 1991-05-27
US4704382A (en) 1987-11-03
DK355686D0 (da) 1986-07-25
FI82834C (sv) 1991-04-25
DK355686A (da) 1987-01-30
GR861958B (en) 1986-12-22
AU6055586A (en) 1987-02-05
NZ216971A (en) 1989-05-29
IL79525A (en) 1990-06-10
EP0211346B1 (en) 1989-09-13
NO863037L (no) 1987-01-30
PT83078B (pt) 1988-07-01
EP0211346A2 (en) 1987-02-25
PH23037A (en) 1989-03-10
CA1275412C (en) 1990-10-23
FI863064A (fi) 1987-01-30
PT83078A (en) 1986-08-01
EP0211346A3 (en) 1987-05-27
DE3665589D1 (en) 1989-10-19

Similar Documents

Publication Publication Date Title
FI82834B (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara fenylpiperazinfosfonater.
FI81090C (sv) Förfarande för framställning av terapeutiskt användbara 1,4-dihydropyr idiner och därvid användbara mellanprodukter
US4593042A (en) Bicyclo-substituted phenylacetonitrile derivatives
JP4023841B2 (ja) ヘテロサイクリル−ベンゾイルグアニジン化合物
FI100969B (sv) Förfarande för framställning av en terapeutiskt aktivt pyrazolo£1,5-a| pyridinförening
CZ280760B6 (cs) Nové pyrazinové deriváty, způsob výroby a farmaceutické prostředky s jejich obsahem
IE55904B1 (en) Dihydropyridines
EP0183216B1 (en) N-(aralkoxybenzyl)-4(benzhydryl) piperidines
EP0191867A1 (en) Tryciclic or tetracyclic compounds, process for their preparation, and medicinal composition containing them
EP0257616B1 (en) Dihydropyridine derivates and pharmaceutical composition thereof
FI65616C (fi) Foerfarande foer framstaellning av farmaceutiskt anvaendbara 1-oxadiazolylfenoxi-3-(4-fenylpiperazinyl)-propanol-2-derivat
GB2171997A (en) 4-Amino-6,7-dimethoxy-2-Piperazin-1-ylquinazoline derivatives
US4259334A (en) Piperazines and therapeutic utility
US4479948A (en) Triazino(2,1-a)isoquinoline derivatives, compositions and their use as medicaments
CZ177892A3 (en) AMINOMETHYL SUBSTITUTED 2,3-DIHYDROPYRAN(2,3-b)PYRIDINES, PROCESS OF THEIR PREPARATION AND THEIR USE IN MEDICAMENTS
US4886819A (en) Dihydropyridine derivatives and pharmaceutical composition thereof
HU193046B (en) Process for preparing aplha-aryl-alpha-pyridyl-alkyl-carboxylic acid derivatives and pharmaceutical compositions
JP2879918B2 (ja) カルシウム拮抗剤
EP2046748B1 (en) Phenylpentadienoyl derivatives and their use as par 1 antagonists
EP0219813B1 (en) Bicyclo-substituted phenylacetonitrile derivatives
NZ270567A (en) N-(4-(trimethoxybenzyl)piperazin-1-ylalkyl) sulphonamide derivatives and pharmaceutical compositions
IE922412A1 (en) 1,4-dihydropyridines with PAF-antagonistic activity
CA2377226C (en) Benzimidazole compounds and medicaments comprising the same
WO1996005174A1 (fr) Nouveau derive amine, procede pour le preparer et son utilisation comme antiarythmique
US3804836A (en) N-phenyl-n&#39;-dialkylphosphinylalkyl-piperazines

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: G D SEARLE & CO.