FI820998L - 9-/2-(3-indolyl)etyl/-1-oxa-4,9-diazaspiro/5,5/undekan-3-oner - Google Patents
9-/2-(3-indolyl)etyl/-1-oxa-4,9-diazaspiro/5,5/undekan-3-onerInfo
- Publication number
- FI820998L FI820998L FI820998A FI820998A FI820998L FI 820998 L FI820998 L FI 820998L FI 820998 A FI820998 A FI 820998A FI 820998 A FI820998 A FI 820998A FI 820998 L FI820998 L FI 820998L
- Authority
- FI
- Finland
- Prior art keywords
- carbon atoms
- etyl
- oner
- undecan
- diazaspiro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/246,459 US4332804A (en) | 1981-03-23 | 1981-03-23 | 9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones |
Publications (1)
Publication Number | Publication Date |
---|---|
FI820998L true FI820998L (fi) | 1982-09-24 |
Family
ID=22930776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI820998A FI820998L (fi) | 1981-03-23 | 1982-03-22 | 9-/2-(3-indolyl)etyl/-1-oxa-4,9-diazaspiro/5,5/undekan-3-oner |
Country Status (19)
Country | Link |
---|---|
US (1) | US4332804A (da) |
EP (1) | EP0061333B1 (da) |
JP (1) | JPS57169485A (da) |
KR (1) | KR830009094A (da) |
AT (1) | ATE17249T1 (da) |
AU (1) | AU557094B2 (da) |
BR (1) | BR8201589A (da) |
DE (1) | DE3268225D1 (da) |
DK (1) | DK129282A (da) |
ES (1) | ES510649A0 (da) |
FI (1) | FI820998L (da) |
IE (1) | IE52652B1 (da) |
IL (1) | IL65310A (da) |
NO (1) | NO820937L (da) |
NZ (1) | NZ200085A (da) |
PH (1) | PH17233A (da) |
PL (1) | PL235561A1 (da) |
PT (1) | PT74626B (da) |
ZA (1) | ZA821929B (da) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4977178A (en) * | 1982-09-20 | 1990-12-11 | Pfizer Inc. | Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents |
US4861880A (en) * | 1982-09-20 | 1989-08-29 | Pfizer Inc. | 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents |
US4879391A (en) * | 1982-09-20 | 1989-11-07 | Pfizer Inc. | 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents |
GB8808433D0 (en) * | 1988-04-11 | 1988-05-11 | Merck Sharp & Dohme | Therapeutic agents |
ATE348808T1 (de) | 2000-03-06 | 2007-01-15 | Acadia Pharm Inc | Azacyclische verbindungen zur verwendung in der behandlung von mit serotonin verwandten krankheiten |
EP1461339B1 (en) * | 2001-12-28 | 2010-04-28 | Acadia Pharmaceuticals Inc. | Spiroazacyclic compounds as monoamine receptor modulators |
US7538222B2 (en) * | 2002-06-24 | 2009-05-26 | Acadia Pharmaceuticals, Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
US7253186B2 (en) * | 2002-06-24 | 2007-08-07 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
CA2490397A1 (en) * | 2002-06-24 | 2003-12-31 | Acadia Pharmaceuticals Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
CN1816524B (zh) | 2003-01-16 | 2012-06-27 | 阿卡蒂亚药品公司 | 用于神经退行性疾病的治疗的选择性五羟色胺2a/2c受体反向激动剂 |
US20050261278A1 (en) * | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
US7820695B2 (en) * | 2004-05-21 | 2010-10-26 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
US7790899B2 (en) * | 2004-09-27 | 2010-09-07 | Acadia Pharmaceuticals, Inc. | Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms |
EP2289879B1 (en) * | 2004-09-27 | 2014-11-12 | Acadia Pharmaceuticals Inc. | Synthesis of a crystalline form of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide tartrate salt |
CA2681506C (en) | 2007-03-19 | 2016-05-24 | Perry Peters | Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics |
HUE037639T2 (hu) * | 2007-09-21 | 2018-09-28 | Acadia Pharm Inc | Pimavanszerin együttes beadása más szerekkel |
TWI685497B (zh) * | 2014-06-02 | 2020-02-21 | 西班牙商伊史帝夫製藥公司 | 具有多重模式抗疼痛活性的1-氧雜-4,9-二氮雜螺十一烷化合物之烷基衍生物 |
PT3325444T (pt) | 2015-07-20 | 2021-09-22 | Acadia Pharm Inc | Métodos para preparar n-(4-fluorobenzil)-n-(1-metilpiperidina-4-il)-n'-(4-(2-metilpropiloxi)fenilmetil)carbamida e o seu sal de tartarato e forma polimórfica c |
MX2018005439A (es) | 2015-11-16 | 2018-11-09 | Esteve Labor Dr | Compuestos oxadiazoespiricos para el tratamiento del abuso y la adiccion a las drogas. |
WO2017165635A1 (en) | 2016-03-25 | 2017-09-28 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome p450 modulators |
US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
EP3558311A1 (en) | 2016-12-20 | 2019-10-30 | Acadia Pharmaceuticals Inc. | Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis |
EP3615028A1 (en) | 2017-04-28 | 2020-03-04 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
US20210077479A1 (en) | 2017-08-30 | 2021-03-18 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
BR112020007359A2 (pt) | 2017-10-17 | 2020-09-29 | Esteve Pharmaceuticals, S.A. | sais de (r)-9-(2,5-difluorofenetil)-4-etil-2-metil-1-oxa-4,9-diazaespiro[5.5]undecan-3-ona |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3481942A (en) * | 1968-09-06 | 1969-12-02 | Smithkline Corp | Oxa-diazaspiro(4.5)decane compounds |
US3574204A (en) * | 1969-07-03 | 1971-04-06 | Yoshitomi Pharmaceutical | Piperidine spiro compounds |
CA952908A (en) * | 1970-02-27 | 1974-08-13 | Yoshitomi Pharmaceutical Industries | Benzodioxane derivatives |
US3723442A (en) * | 1970-12-31 | 1973-03-27 | Yoshitomi Pharmaceutical | 3-oxo-1-oxa-4,8-diazaspiro(4.5)decanes |
US4255432A (en) * | 1979-09-06 | 1981-03-10 | Syntex (U.S.A.) Inc. | 8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof |
-
1981
- 1981-03-23 US US06/246,459 patent/US4332804A/en not_active Expired - Fee Related
-
1982
- 1982-02-22 BR BR8201589A patent/BR8201589A/pt unknown
- 1982-03-22 NO NO820937A patent/NO820937L/no unknown
- 1982-03-22 PH PH27035A patent/PH17233A/en unknown
- 1982-03-22 AU AU81769/82A patent/AU557094B2/en not_active Expired - Fee Related
- 1982-03-22 IL IL65310A patent/IL65310A/xx unknown
- 1982-03-22 FI FI820998A patent/FI820998L/fi not_active Application Discontinuation
- 1982-03-22 DE DE8282301460T patent/DE3268225D1/de not_active Expired
- 1982-03-22 DK DK129282A patent/DK129282A/da not_active Application Discontinuation
- 1982-03-22 ES ES510649A patent/ES510649A0/es active Granted
- 1982-03-22 AT AT82301460T patent/ATE17249T1/de not_active IP Right Cessation
- 1982-03-22 NZ NZ200085A patent/NZ200085A/en unknown
- 1982-03-22 EP EP82301460A patent/EP0061333B1/en not_active Expired
- 1982-03-22 PL PL23556182A patent/PL235561A1/xx unknown
- 1982-03-22 IE IE648/82A patent/IE52652B1/en unknown
- 1982-03-22 KR KR1019820001218A patent/KR830009094A/ko unknown
- 1982-03-22 ZA ZA821929A patent/ZA821929B/xx unknown
- 1982-03-22 PT PT74626A patent/PT74626B/pt unknown
- 1982-03-23 JP JP57044755A patent/JPS57169485A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE3268225D1 (de) | 1986-02-13 |
EP0061333A1 (en) | 1982-09-29 |
ES8306373A1 (es) | 1983-06-01 |
IL65310A (en) | 1985-03-31 |
ES510649A0 (es) | 1983-06-01 |
US4332804A (en) | 1982-06-01 |
NO820937L (no) | 1982-09-24 |
AU557094B2 (en) | 1986-12-04 |
ZA821929B (en) | 1983-11-30 |
AU8176982A (en) | 1982-09-30 |
PH17233A (en) | 1984-07-03 |
DK129282A (da) | 1982-09-24 |
NZ200085A (en) | 1985-07-12 |
BR8201589A (pt) | 1983-02-08 |
EP0061333B1 (en) | 1986-01-02 |
ATE17249T1 (de) | 1986-01-15 |
PL235561A1 (da) | 1982-10-25 |
IL65310A0 (en) | 1982-05-31 |
PT74626B (en) | 1983-12-19 |
PT74626A (en) | 1982-04-01 |
IE820648L (en) | 1982-09-23 |
JPS57169485A (en) | 1982-10-19 |
IE52652B1 (en) | 1988-01-06 |
KR830009094A (ko) | 1983-12-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |
Owner name: SYNTEX (USA) INC |