FI80272B - Foerfarande foer framstaellning av terapeutiskt anvaendbara pyrazolderivat med ergolinskelett samt deras syraadditionssalter. - Google Patents
Foerfarande foer framstaellning av terapeutiskt anvaendbara pyrazolderivat med ergolinskelett samt deras syraadditionssalter. Download PDFInfo
- Publication number
- FI80272B FI80272B FI842233A FI842233A FI80272B FI 80272 B FI80272 B FI 80272B FI 842233 A FI842233 A FI 842233A FI 842233 A FI842233 A FI 842233A FI 80272 B FI80272 B FI 80272B
- Authority
- FI
- Finland
- Prior art keywords
- group
- beta
- hydrogen atom
- alkyl
- ene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (3)
1. Förfarande för framställning av terapeutiskt användbara pyrazolderivat och farmaceutiskt lämpliga salter därav med ergolinstomme och uppvisande formel I K N—{-N ^ , -ch3 I R H väri x...y betyder en -CH=C- eller -CH2-CH-grupp, R betyder en väteatom eller en metylgrupp. Rl betyder en väteatom, en Ci_4-alkyl-, karbetoxi- eller pyridylgrupp, R2 representerar en väteatom, en Ci_4~alkyl-, -allyl-, C2-4~oxoal^yl"/ C2_4-hydroxialkyl- eller 02-4-hydroxiiminoalkylgrupp, R3 betyder en väteatom, en Ci_4-alkyl-, hydroxi- eller pyridylgrupp, vidare kan R2 och R3 tillsammans betyda en grupp med formeln (II), 24 80272 f, ι-h 11 I Mk vari Z är en metylen-, karbonyl-, hydroximetylen- eller hydroxiiminometylengrupp, R4 betyder väteatom eller en eller tvä Ci_4-alkylgrup-per och n är 1 eller 2, kännetecknat av att en hydrazinförening med den allmänna formeln (III) CHj-NH-NH, 111 R-N-1· vari x...y och R betyder samma som ovan, omsätts a) med en beta-diketon med den allmänna formeln (IV) Qx i IV Q-CO-CH-CO-Q, väri och Q2 betyder oberoende av varandra en Ci-4-alkyl-, etoxi-, karbetoxi- eller pyridylgrupp och Q2 betyder en väteatom, en C1_4_alkyl_f -allyl- eller en C2_4-oxoalkylgrupp, eller b) med en cykloalkanon med den allmänna formeln (V) 25 80272 R, zV| R-CoAjfH,)„ v 0 väri Ri representerar en väteatom, en C^_4-alkyl-eller pyridylgrupp, Z' star för en metylen- eller karbonylgrupp, R4 betyder en väteatom eller en Ci-4-alkylgrupp eller flera dylika och n är 1 eller 2, varefter, om sa önskas, reduceras eller överförs den med forfarande a) eller b) erhallna föreningen i en oxim och/eller överförs den i ett farmaceutiskt lämpligt salt.
2. Förfarande enligt patentkrav 1, kännetecknat av att man framställer 8-beta-[3(5)-metylcyklopentano- /4,5(3,4)/pyrazol-l-ylmetylen]-6-metylergol-9-en.
3. Förfarande enligt patentkrav 1, kännetecknat ·: av att man framställer 8-beta-[3(5)-metylcyklopentano- /4,5(3,4)/pyrazol-l-ylmetylen]-6-metylergol-9-en-vätefumarat.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU200183 | 1983-06-03 | ||
| HU832001A HU190105B (en) | 1983-06-03 | 1983-06-03 | Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI842233A0 FI842233A0 (fi) | 1984-06-04 |
| FI842233A FI842233A (fi) | 1984-12-04 |
| FI80272B true FI80272B (fi) | 1990-01-31 |
| FI80272C FI80272C (sv) | 1990-05-10 |
Family
ID=10957235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI842233A FI80272C (sv) | 1983-06-03 | 1984-06-04 | Förfarande för framställning av terapeutiskt användbara pyrazolderivat med ergolinskelett samt deras syraadditionssalter |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4632928A (sv) |
| EP (1) | EP0128479B1 (sv) |
| JP (1) | JPS6084286A (sv) |
| AR (1) | AR240323A1 (sv) |
| AT (1) | ATE55129T1 (sv) |
| AU (1) | AU569518B2 (sv) |
| CA (1) | CA1252086A (sv) |
| DE (1) | DE3482854D1 (sv) |
| DK (1) | DK162050C (sv) |
| ES (1) | ES8800940A1 (sv) |
| FI (1) | FI80272C (sv) |
| GR (1) | GR82419B (sv) |
| HU (1) | HU190105B (sv) |
| IL (1) | IL71988A (sv) |
| ZA (1) | ZA844162B (sv) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2173189B (en) * | 1985-02-21 | 1988-04-27 | Maruko Pharmaceutical Co | Ergoline derivatives and salts thereof and pharmaceutical compositions thereof |
| GB8702364D0 (en) * | 1987-02-03 | 1987-03-11 | Erba Farmitalia | Ergolinyl heterocycles |
| GB9603226D0 (en) * | 1996-02-15 | 1996-04-17 | Pharmacia Spa | Heterocyclyl-ergoline derivatives |
| US6369089B1 (en) | 2000-09-14 | 2002-04-09 | Allergan Sales, Inc. | Interheteroaryl 7-oxabicyclic [2.2.1]heptane oxazoles as prostaglandin F2α antagonists |
| US6511999B2 (en) | 2000-09-14 | 2003-01-28 | Allergan, Inc. | Interheteroaryl 7-oxabicyclic [2.2.1]heptane oxazoles as prostaglandin F2α antagonists |
| US6407250B1 (en) | 2000-09-14 | 2002-06-18 | Allergan Sales, Inc. | Interphenylene 7-oxabicyclic [2.2.1] heptane oxazoles as prostaglandin F2a antagonists |
| US7045634B2 (en) * | 2003-09-05 | 2006-05-16 | Allergan, Inc. | Prostamide receptor antagonists |
| US20100256385A1 (en) * | 2009-04-02 | 2010-10-07 | Allergan, Inc. | Prostaglandin e receptor antagonists |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1695752C3 (de) * | 1966-07-29 | 1974-06-06 | Societa Farmaceutici Italia, Mailand (Italien) | 1 ,ö-Dimethyl-ebeta-N-carbobenzoxyaminomethyl-2,3-dihydro-1 Oalpha-ergolin und ein Verfahren zu seiner Herstellung |
| US4134987A (en) * | 1976-01-14 | 1979-01-16 | Huppatz John L | Compounds and compositions |
| HU178396B (en) * | 1978-03-20 | 1982-04-28 | Vianova Kunstharz Ag | Process for producing new 8-beta-hydrazion-methyl-ergoline-and -ergolene derivatives |
| GB2056437A (en) * | 1979-08-07 | 1981-03-18 | Erba Farmitalia | Secoergoline derivatives |
| GB2120242A (en) * | 1982-04-30 | 1983-11-30 | Erba Farmitalia | Ergoline derivatives |
-
1983
- 1983-06-03 HU HU832001A patent/HU190105B/hu not_active IP Right Cessation
-
1984
- 1984-05-30 US US06/615,387 patent/US4632928A/en not_active Expired - Fee Related
- 1984-06-01 JP JP59111053A patent/JPS6084286A/ja active Granted
- 1984-06-01 DK DK273884A patent/DK162050C/da not_active IP Right Cessation
- 1984-06-01 EP EP84106260A patent/EP0128479B1/en not_active Expired - Lifetime
- 1984-06-01 AT AT84106260T patent/ATE55129T1/de not_active IP Right Cessation
- 1984-06-01 DE DE8484106260T patent/DE3482854D1/de not_active Expired - Fee Related
- 1984-06-01 IL IL8471988A patent/IL71988A/xx unknown
- 1984-06-01 CA CA000455626A patent/CA1252086A/en not_active Expired
- 1984-06-02 ES ES533086A patent/ES8800940A1/es not_active Expired
- 1984-06-04 FI FI842233A patent/FI80272C/sv not_active IP Right Cessation
- 1984-06-04 GR GR74906A patent/GR82419B/el unknown
- 1984-06-04 ZA ZA844162A patent/ZA844162B/xx unknown
- 1984-06-04 AR AR296829A patent/AR240323A1/es active
- 1984-06-04 AU AU29032/84A patent/AU569518B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| FI842233A (fi) | 1984-12-04 |
| HU190105B (en) | 1986-08-28 |
| CA1252086A (en) | 1989-04-04 |
| JPH0342274B2 (sv) | 1991-06-26 |
| ES8800940A1 (es) | 1987-12-01 |
| JPS6084286A (ja) | 1985-05-13 |
| EP0128479A2 (en) | 1984-12-19 |
| ZA844162B (en) | 1984-12-24 |
| GR82419B (sv) | 1984-12-13 |
| IL71988A (en) | 1987-01-30 |
| AU2903284A (en) | 1984-12-06 |
| FI842233A0 (fi) | 1984-06-04 |
| DK273884A (da) | 1984-12-04 |
| AR240323A1 (es) | 1990-03-30 |
| FI80272C (sv) | 1990-05-10 |
| US4632928A (en) | 1986-12-30 |
| DK162050C (da) | 1992-02-10 |
| IL71988A0 (en) | 1984-10-31 |
| AU569518B2 (en) | 1988-02-04 |
| DE3482854D1 (de) | 1990-09-06 |
| EP0128479B1 (en) | 1990-08-01 |
| HUT34748A (en) | 1985-04-28 |
| ATE55129T1 (de) | 1990-08-15 |
| DK273884D0 (da) | 1984-06-01 |
| EP0128479A3 (en) | 1985-10-30 |
| ES533086A0 (es) | 1987-12-01 |
| DK162050B (da) | 1991-09-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: RICTER GEDEON VEGYESZETI GYOER R.T. |