FI70905C - Analogifoerfarande foer framstaellning av terapeutiskt anvaendbara pentapeptidderivat vilka har biologisk foermaoga att inucera differentiering av t-lymfocyter men ej av komplemen trceptor-(cr+)-b-lymfocyter - Google Patents
Analogifoerfarande foer framstaellning av terapeutiskt anvaendbara pentapeptidderivat vilka har biologisk foermaoga att inucera differentiering av t-lymfocyter men ej av komplemen trceptor-(cr+)-b-lymfocyter Download PDFInfo
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- 239000001530 fumaric acid Substances 0.000 description 1
- 230000008570 general process Effects 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000003979 granulating agent Substances 0.000 description 1
- 125000004970 halomethyl group Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- 125000000612 phthaloyl group Chemical group C(C=1C(C(=O)*)=CC=CC1)(=O)* 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920003053 polystyrene-divinylbenzene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- GAPYKZAARZMMGP-UHFFFAOYSA-N pyridin-1-ium;acetate Chemical compound CC(O)=O.C1=CC=NC=C1 GAPYKZAARZMMGP-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229950000244 sulfanilic acid Drugs 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000002992 thymic effect Effects 0.000 description 1
- 210000004367 thymic lymphocyte Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 125000005023 xylyl group Chemical group 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/66—Thymopoietins
- C07K14/662—Thymopoietins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2959579A | 1979-04-12 | 1979-04-12 | |
| US2959579 | 1979-04-12 | ||
| US12495980 | 1980-03-13 | ||
| US06/124,959 US4261886A (en) | 1980-03-13 | 1980-03-13 | Peptides having thymopoietin-like activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI801130A7 FI801130A7 (fi) | 1980-10-13 |
| FI70905B FI70905B (fi) | 1986-07-18 |
| FI70905C true FI70905C (fi) | 1986-10-27 |
Family
ID=26705125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI801130A FI70905C (fi) | 1979-04-12 | 1980-04-09 | Analogifoerfarande foer framstaellning av terapeutiskt anvaendbara pentapeptidderivat vilka har biologisk foermaoga att inucera differentiering av t-lymfocyter men ej av komplemen trceptor-(cr+)-b-lymfocyter |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0018182B1 (Direct) |
| CA (1) | CA1157466A (Direct) |
| DE (1) | DE3060962D1 (Direct) |
| DK (1) | DK149093C (Direct) |
| ES (1) | ES490508A0 (Direct) |
| FI (1) | FI70905C (Direct) |
| GR (1) | GR67737B (Direct) |
| IE (1) | IE49755B1 (Direct) |
| IL (1) | IL59804A (Direct) |
| NO (1) | NO149843C (Direct) |
| NZ (1) | NZ193435A (Direct) |
| PH (1) | PH16200A (Direct) |
| PT (1) | PT71087B (Direct) |
| YU (1) | YU42665B (Direct) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2938420A1 (de) * | 1979-09-22 | 1981-04-09 | Hoechst Ag, 6000 Frankfurt | Neue peptide und verfahren zu ihrer herstellung |
| US4309340A (en) * | 1980-03-31 | 1982-01-05 | American Home Products Corporation | Polypeptide compositions |
| HU185263B (en) * | 1981-06-12 | 1984-12-28 | Richter Gedeon Vegyeszet | Process for producing peptides effective on the immuncontroll analogous with the tp5 |
| US4505853A (en) * | 1983-11-18 | 1985-03-19 | Ortho Pharmaceutical Corporation | Enzyme-resistant immunomodulatory peptides |
| DE3421614A1 (de) * | 1984-06-09 | 1985-12-12 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von pentapeptiden mit wirkung auf das immunsystem und zwischenprodukte dieses verfahrens |
| US4547489A (en) * | 1984-06-11 | 1985-10-15 | Ortho Pharmaceutical Corporation | Conformationally restricted thymopentin-like compounds |
| US4629723A (en) * | 1984-06-27 | 1986-12-16 | Ortho Pharmaceutical Corporation | Potent thymopentin analogs |
| NZ229004A (en) * | 1988-05-19 | 1993-09-27 | Immunobiology Res Inst Inc | Tetrapeptides having t cell helper acitivity |
| HU201964B (en) * | 1989-01-13 | 1991-01-28 | Richter Gedeon Vegyeszet | Process for producing peptides inhibiting maturation of t-lymphocytes and activity of macrophages, as well as pharmaceutical compositions comprising same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4002740A (en) * | 1975-08-21 | 1977-01-11 | Gideon Goldstein | Tridecapeptide compositions and methods |
| US4190646A (en) * | 1975-11-11 | 1980-02-26 | Sloan-Kettering Institute For Cancer Research | Polypeptide compositions and methods |
-
1980
- 1980-04-01 CA CA000348982A patent/CA1157466A/en not_active Expired
- 1980-04-09 FI FI801130A patent/FI70905C/fi not_active Application Discontinuation
- 1980-04-10 IL IL59804A patent/IL59804A/xx not_active IP Right Cessation
- 1980-04-11 DE DE8080301170T patent/DE3060962D1/de not_active Expired
- 1980-04-11 GR GR61666A patent/GR67737B/el unknown
- 1980-04-11 IE IE743/80A patent/IE49755B1/en not_active IP Right Cessation
- 1980-04-11 EP EP80301170A patent/EP0018182B1/en not_active Expired
- 1980-04-11 ES ES490508A patent/ES490508A0/es active Granted
- 1980-04-11 YU YU1004/80A patent/YU42665B/xx unknown
- 1980-04-11 PT PT71087A patent/PT71087B/pt not_active IP Right Cessation
- 1980-04-11 NO NO801061A patent/NO149843C/no unknown
- 1980-04-11 PH PH23887A patent/PH16200A/en unknown
- 1980-04-11 DK DK155780A patent/DK149093C/da not_active IP Right Cessation
- 1980-04-14 NZ NZ193435A patent/NZ193435A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK149093C (da) | 1986-06-23 |
| ES8103029A1 (es) | 1981-02-16 |
| NO801061L (no) | 1980-10-13 |
| DK149093B (da) | 1986-01-20 |
| YU42665B (en) | 1988-10-31 |
| FI70905B (fi) | 1986-07-18 |
| IL59804A (en) | 1983-03-31 |
| ES490508A0 (es) | 1981-02-16 |
| PT71087B (en) | 1981-08-07 |
| IL59804A0 (en) | 1980-06-30 |
| CA1157466A (en) | 1983-11-22 |
| IE49755B1 (en) | 1985-12-11 |
| EP0018182B1 (en) | 1982-10-20 |
| IE800743L (en) | 1980-10-12 |
| NO149843C (no) | 1984-07-04 |
| DE3060962D1 (en) | 1982-11-25 |
| FI801130A7 (fi) | 1980-10-13 |
| NZ193435A (en) | 1984-07-06 |
| GR67737B (Direct) | 1981-09-16 |
| PH16200A (en) | 1983-07-28 |
| YU100480A (en) | 1983-02-28 |
| NO149843B (no) | 1984-03-26 |
| DK155780A (da) | 1980-10-13 |
| EP0018182A1 (en) | 1980-10-29 |
| PT71087A (en) | 1980-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |
Owner name: ORTHO PHARMACEUTICAL CORPORATION |